J. Klein

发表

Calcineurin phosphatase activity: activation by glucocorticoids and role of intracellular calcium1

B. Roberts, J. Tumlin, David C K Tong, 2004, Transplantation.

Regulation by cell volume of Na+-K+-2Cl− cotransport in vascular endothelial cells: role of protein phosphorylation

W. C. O'Neill, J. Klein, P. Perry, 1993, The Journal of Membrane Biology.

Volume-sensitive myosin phosphorylation in vascular endothelial cells: correlation with Na-K-2Cl cotransport.

W. C. O'Neill, J. Klein, 1995, The American journal of physiology.

NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip

Baoxue Yang, J. Sands, Huiwen Ren, 2015, PloS one.

Urea transport in MDCK cells that are stably transfected with UT-A1.

R. Gunn, J. Sands, O. Fröhlich, 2004, American journal of physiology. Cell physiology.

GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage.

J. Sands, N. Yanaka, T. Izumi, 2019, American journal of physiology. Cell physiology.

PKC-α contributes to high NaCl-induced activation of NFAT5 (TonEBP/OREBP) through MAPK ERK1/2.

M. Burg, J. Sands, J. Ferraris, 2015, American journal of physiology. Renal physiology.

Cyclooxygenase-2 in the kidney: good, BAD, or both?

J. Klein, S. Russ Price, 2011, Kidney international.

Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism.

S. Tam, S. Chung, Hong Guo, 2006, American journal of physiology. Renal physiology.

XIAP reduces muscle proteolysis induced by CKD.

Jie Du, Xiaonan H. Wang, Liping Zhang, 2010, Journal of the American Society of Nephrology : JASN.

Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.

J. Sands, J. Verlander, R. Seshadri, 2006, American journal of physiology. Renal physiology.

Changes in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis.

J. Sands, J. Verlander, R. Seshadri, 2006, American journal of physiology. Renal physiology.

Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-α and its receptor 1.

G. Striker, F. Grosjean, J. Sands, 2011, Kidney international.

Inhibition of urea transporter ameliorates uremic cardiomyopathy in chronic kidney disease

Xiaonan H. Wang, J. Sands, Nawazish Naqvi, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency.

Jie Du, Xiaonan H. Wang, J. Klein, 2008, Endocrinology.

Impaired urine concentration and absence of tissue ACE: involvement of medullary transport proteins.

Anne K. Mongiu, K. Bernstein, J. Sands, 2002, American journal of physiology. Renal physiology.

Decreased miR-29 suppresses myogenesis in CKD.

W. Mitch, Fude Fang, Zhaoyong Hu, 2011, Journal of the American Society of Nephrology : JASN.

Heat shock proteins 70 and 90 increase calcineurin activity in vitro through calmodulin-dependent and independent mechanisms.

J. Tumlin, L. E. Faber, J. Klein, 1999, Biochemical and biophysical research communications.

Mature N‐linked glycans facilitate UT‐A1 urea transporter lipid raft compartmentalization

Guangping Chen, J. Sands, O. Fröhlich, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy.

Xiaonan H. Wang, Z. Su, J. Klein, 2016, Journal of applied physiology.

Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function.

W. Mitch, Jie Du, Xiaonan H. Wang, 2009, Kidney international.

Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts.

J. Sands, O. Fröhlich, Mitsi A Blount, 2006, Journal of the American Society of Nephrology : JASN.

97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation.

M. Knepper, J. Sands, C. Chou, 2001, American journal of physiology. Renal physiology.

Stimulation of UT-A1-mediated transepithelial urea flux in MDCK cells by lithium.

R. Gunn, J. Sands, O. Fröhlich, 2008, American journal of physiology. Renal physiology.

Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus.

R. Walker, J. Sands, J. Leader, 2008, American journal of physiology. Renal physiology.

Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats.

R. Gunn, B. Roberts, J. Sands, 2002, Kidney international.

Effect of age and testosterone on the vasopressin and aquaporin responses to dehydration in Fischer 344/Brown-Norway F1 rats.

C. Sladek, J. Sands, J. Klein, 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

Exogenous miR‐26a suppresses muscle wasting and renal fibrosis in obstructive kidney disease

Xiaonan H. Wang, Bin Wang, J. Klein, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Chronic kidney disease induces autophagy leading to dysfunction of mitochondria in skeletal muscle.

Xiaonan H. Wang, Liping Zhang, Z. Su, 2017, American journal of physiology. Renal physiology.

Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2.

S. Price, J. Klein, Yongmei Gao, 2008, Journal of applied physiology.

Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus.

J. Sands, Huiwen Ren, J. Klein, 2016, JCI insight.

Acidosis mediates the upregulation of UT-A protein in livers from uremic rats.

B. Roberts, J. Sands, J. Klein, 2002, Journal of the American Society of Nephrology : JASN.

Exogenous miR-29a attenuates muscle atrophy and kidney fibrosis in UUO mice.

Xiaonan H. Wang, Bin Wang, Aiqing Zhang, 2020, Human gene therapy.

Paper miR-26 a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease

Xiaonan H. Wang, Bin Wang, Aiqing Zhang, 2019 .

Low-frequency electrical stimulation attenuates muscle atrophy in CKD--a potential treatment strategy.

Xiaonan H. Wang, J. Klein, Faten Hassounah, 2015, Journal of the American Society of Nephrology : JASN.

Acupuncture plus Low-Frequency Electrical Stimulation (Acu-LFES) Attenuates Diabetic Myopathy by Enhancing Muscle Regeneration

Xiaonan H. Wang, Z. Su, J. Klein, 2015, PloS one.

miR-26 a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease

Xiaonan H. Wang, Bin Wang, Aiqing Zhang, 2022 .

Effect of Dapagliflozin Treatment on Fluid and Electrolyte Balance in Diabetic Rats

Juan Wang, J. Sands, J. Klein, 2016, The American journal of the medical sciences.

Urea Transporters in Health and Disease

J. Sands, J. Klein, 2020 .

Urea transport in the kidney.

J. Sands, Mitsi A Blount, J. Klein, 2011, Comprehensive Physiology.

Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues.

R. Gunn, J. Sands, J. Verlander, 2001, American journal of physiology. Cell physiology.

Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon.

K. Tomita, S. Bagnasco, J. Klein, 2004, American journal of physiology. Cell physiology.

clathrin-coated pit pathways dependent and mediated by both caveolae- and Internalization of UT-A1 urea transporter is dynamin

Guangping Chen, J. Sands, Xiuyan Feng, 2016 .

Internalization of UT-A1 urea transporter is dynamin dependent and mediated by both caveolae- and clathrin-coated pit pathways.

Guangping Chen, J. Sands, Xiuyan Feng, 2010, American journal of physiology. Renal physiology.

Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice.

D. Kohan, B. Kishore, Yue Zhang, 2008, American journal of physiology. Renal physiology.

Protein abundance of urea transporters and aquaporin 2 change differently in nephrotic pair-fed vs. non-pair-fed rats.

Xiaonan H. Wang, J. Sands, D. Eaton, 2012, American journal of physiology. Renal physiology.

Urea transporters are distributed in endothelial cells and mediate inhibition of L-arginine transport.

J. Sands, L. Wagner, C. Baylis, 2002, American journal of physiology. Renal physiology.

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation

M. Rauh, A. Nishiyama, F. Luft, 2017, The Journal of clinical investigation.

Erlotinib Preserves Renal Function and Prevents Salt Retention in Doxorubicin Treated Nephrotic Rats

J. Sands, Raed N Bou Matar, J. Klein, 2013, PloS one.

GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.

H. Wiig, J. Sands, S. Bachmann, 2017, Journal of the American Society of Nephrology : JASN.

Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in Unilateral Ureteral Obstruction Mice

J. Klein, Yajie Zhao, W. He, 2020 .

The UT-A1 Urea Transporter Interacts with Snapin, a SNARE-associated Protein*

A. Rehm, Guangping Chen, J. Sands, 2007, Journal of Biological Chemistry.

Electrical acupuncture increases protein synthesis through downregulation of let-7

Xiaonan H. Wang, J. Klein, A. Kuma, 2020 .

Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4.

R. Gunn, A. Karakashian, J. Sands, 1999, Journal of the American Society of Nephrology : JASN.

High glucose reduces the expression of podocin in cultured human podocytes by stimulating TRPC6.

Guangping Chen, Lihua Wang, Chang Hun Song, 2019, American journal of physiology. Renal physiology.

Shrinkage-induced activation of Na+/H+ exchange in primary rat astrocytes: role of myosin light-chain kinase.

R. Putnam, W. C. O'Neill, J. Klein, 1995, The American journal of physiology.

Regulation of vascular endothelial cell volume by Na-K-2Cl cotransport.

W. C. O'Neill, J. Klein, W. O'Neill, 1992, The American journal of physiology.

Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA.

J. Sands, J. Klein, Chi Zhang, 2002, American journal of physiology. Renal physiology.

Glucocorticoids mediate a decrease in AVP-regulated urea transporter in diabetic rat inner medulla.

S. Price, J. Sands, J. Bailey, 1997, The American journal of physiology.

Syntaxin specificity of aquaporins in the inner medullary collecting duct.

T. Weimbs, J. Sands, O. Fröhlich, 2009, American journal of physiology. Renal physiology.

Dexamethasone increases aquaporin-2 protein expression in ex vivo inner medullary collecting duct suspensions

Guangping Chen, J. Klein, Minguang Chen, 2015, Front. Physiol..

Shrinkage-induced activation of Na+/H+ exchange: role of cell density and myosin light chain phosphorylation.

R. Putnam, W. C. O'Neill, J. Klein, 1997, The American journal of physiology.

The angiotensin II AT1 receptor is tyrosine and serine phosphorylated and can serve as a substrate for the src family of tyrosine kinases.

B. Berk, M. Marrero, K. Bernstein, 1994, Biochemical and biophysical research communications.

senescenceincreases CCN1 expression leading to muscle

Xiaonan H. Wang, Jie Du, J. Klein, 2016 .

Aging increases CCN1 expression leading to muscle senescence.

Xiaonan H. Wang, Jie Du, J. Klein, 2014, American journal of physiology. Cell physiology.

transporter from the kidney of a short-finned pilot whale Molecular and functional characterization of a urea

M. Janech, Ruihua Chen, W. McFee, 2016 .

Glucocorticoids downregulate the vasopressin-regulated urea transporter in rat terminal inner medullary collecting ducts.

J. Sands, M. Naruse, J. Klein, 1997, Journal of the American Society of Nephrology : JASN.

JNK is a volume-sensitive kinase that phosphorylates the Na-K-2Cl cotransporter in vitro.

W. C. O'Neill, S. T. Lamitina, J. Klein, 1999, American journal of physiology. Cell physiology.

The Role of Intercalated Cell Nedd4-2 in BP Regulation, Ion Transport, and Transporter Expression.

Xiaonan H. Wang, R. Chambrey, Masayoshi Nanami, 2018, Journal of the American Society of Nephrology : JASN.

Aldosterone Regulates the Na-K-2Cl Cotransporter in Vascular Smooth Muscle

W. C. O'Neill, J. Klein, G. Jiang, 2003, Hypertension.

Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor.

J. Sands, Xiaoqing Luo, J. Bailey, 2004, Journal of the American Society of Nephrology : JASN.

UT-A Urea Transporter Protein in Heart: Increased Abundance During Uremia, Hypertension, and Heart Failure

B. Roberts, J. Sands, A. McDonough, 2001, Circulation research.

UT-A1/A3 Knockout Mice Show Reduced Fibrosis Following Unilateral Ureteral Obstruction.

Xiaonan H. Wang, J. Sands, J. Klein, 2020, American journal of physiology. Renal physiology.

14-3-3 gamma, a novel regulator of the large-conductance Ca2+-activated K+ channels.

H. Fu, Xiaonan H. Wang, R. Hoover, 2020, American journal of physiology. Renal physiology.

Aldosterone Decreases Vasopressin-Stimulated Water Reabsorption in Rat Inner Medullary Collecting Ducts

J. Sands, J. Klein, Fuying Ma, 2020, Cells.

Regulation of renal urea transport by vasopressin.

J. Sands, Mitsi A Blount, J. Klein, 2011, Transactions of the American Clinical and Climatological Association.

ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase Cα knockout mice.

J. Sands, D. Eaton, H. Bao, 2014, American journal of physiology. Renal physiology.

UT-A urea transporter protein expressed in liver: upregulation by uremia.

J. Sands, J. Bailey, J. Klein, 1999, Journal of the American Society of Nephrology : JASN.

uncontrolled diabetes mellitus in rats Changes in renal medullary transport proteins during

J. Sands, J. Klein, Dongun Kim, 2016 .

Molecular mechanisms of urea transport in health and disease

J. Sands, Mitsi A Blount, J. Klein, 2012, Pflügers Archiv - European Journal of Physiology.

The Role of Nitric Oxide in the Dysregulation of the Urine Concentration Mechanism in Diabetes Mellitus

Mitsi A Blount, J. Klein, J. Sim, 2012, Front. Physio..

Vasopressin increases urea permeability in the initial IMCD from diabetic rats.

J. Sands, S. Wall, J. Klein, 2005, American journal of physiology. Renal physiology.

Changes in renal medullary transport proteins during uncontrolled diabetes mellitus in rats.

J. Sands, J. Klein, Dongun Kim, 2003, American journal of physiology. Renal physiology.

Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load.

J. Sands, J. Bailey, S. Bagnasco, 2005, American journal of physiology. Renal physiology.

The impact of senescence on muscle wasting in chronic kidney disease

Bin Wang, S. Price, Xuemei Zhang, 2022, Journal of cachexia, sarcopenia and muscle.

Expression of urea transporters and their regulation.

J. Klein, 2014, Sub-cellular biochemistry.

Role of protein kinase C-α in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ducts.

J. Sands, J. Klein, Yanhua Wang, 2013, American journal of physiology. Renal physiology.

Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension.

J. Sands, Mitsi A Blount, J. Klein, 2012, American journal of physiology. Renal physiology.

miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease

Xiaonan H. Wang, Bin Wang, Aiqing Zhang, 2019, Theranostics.

An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus

I. Khanna, J. Sands, J. Klein, 2021, JCI insight.

Adrenomedullin Inhibits Osmotic Water Permeability in Rat Inner Medullary Collecting Ducts

Guangping Chen, J. Sands, J. Klein, 2020, Cells.

Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity.

J. Sands, Mitsi A Blount, J. Klein, 2008, American journal of physiology. Renal physiology.

Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation.

Guangping Chen, S. Price, J. Sands, 2008, American journal of physiology. Renal physiology.

Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.

J. Sands, D. Tchapyjnikov, Mitsi A Blount, 2007, American journal of physiology. Renal physiology.

Expression of transporters involved in urine concentration recovers differently after cessation of lithium treatment.

J. Sands, Rong Zhou, Mitsi A Blount, 2010, American journal of physiology. Renal physiology.

Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet.

J. Wilcox, J. Sands, M. Naruse, 1996, The Journal of clinical investigation.

Pigmented villonodular synovitis containing coarse calcifications.

N. Weidner, B. Weissman, J. Klein, 1989, AJR. American journal of roentgenology.

Effect of nitrogen intake on nitrogen recycling and urea transporter abundance in lambs.

J. Marini, J. Sands, M. Van Amburgh, 2004, Journal of animal science.

Growth factors stimulate the Na-K-2Cl cotransporter NKCC1 through a novel Cl(-)-dependent mechanism.

W. C. O'Neill, J. Klein, G. Jiang, 2001, American journal of physiology. Cell physiology.

Loss of N-Linked Glycosylation Reduces Urea Transporter UT-A1 Response to Vasopressin*

Guangping Chen, J. Sands, O. Fröhlich, 2006, Journal of Biological Chemistry.

Vasoconstrictors and nitrovasodilators reciprocally regulate the Na+-K+-2Cl-cotransporter in rat aorta.

W. C. O'Neill, R. Paul, Fatma Akar, 1999, American journal of physiology. Cell physiology.

Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure

M. Rauh, A. Nishiyama, F. Luft, 2021, Acta physiologica.

Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B.

Baoxue Yang, J. Sands, J. Klein, 2004, Journal of the American Society of Nephrology : JASN.

Altered expression of urea transporters in response to ureteral obstruction.

J. Frøkiaer, S. Nielsen, M. Knepper, 2004, American journal of physiology. Renal physiology.

Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding.

J. Sands, O. Fröhlich, J. Klein, 2010, American journal of physiology. Cell physiology.

Urea Transporter B and MicroRNA‐200c Differ in Kidney Outer Versus Inner Medulla Following Dehydration

Xiaonan H. Wang, Juan Wang, J. Sands, 2016, The American journal of the medical sciences.

Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα‐dependent manner

S. Srinivasan, C. Yun, Peijian He, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways

W. Mitch, Zhaoyong Hu, Xiaonan H. Wang, 2014, Aging.

X-chromosome linked inhibitor of apoptosis protein inhibits muscle proteolysis in insulin-deficient mice

Xiaonan H. Wang, J. Hu, J. Klein, 2007, Gene Therapy.

Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice.

M. Wood, Xiaonan H. Wang, Bin Wang, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

Aldosterone regulates Na(+), K(+) ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor.

S. Khundmiri, M. Barati, E. Lederer, 2013, Biochimica et biophysica acta.

Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway.

R. Hoover, J. Bailey, B. Wynne, 2013, American journal of physiology. Renal physiology.

Renal ENaC subunit, Na-K-2Cl and Na-Cl cotransporter abundances in aged, water-restricted F344 x Brown Norway rats.

J. Verbalis, Y. Sugimura, C. Ecelbarger, 2006, Kidney international.

Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs.

J. Sands, J. Klein, A. Kato, 2000, American journal of physiology. Renal physiology.

Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct.

J. Sands, Mitsi A Blount, D. Gumina, 2015, American journal of physiology. Cell physiology.

Activation of protein kinase C increases phosphorylation of the UTA 1 urea transporter at serine 494 in the inner medullary collecting duct

J. Sands, Mitsi A Blount, D. Gumina, 2015 .

Molecular and functional characterization of a urea transporter from the kidney of a short-finned pilot whale.

M. Janech, Ruihua Chen, R. V. Paul, 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats.

J. Sands, J. Klein, Dongun Kim, 2004, American journal of physiology. Renal physiology.

Tissue distribution of UT-A and UT-B mRNA and protein in rat.

R. Gunn, J. Sands, J. Klein, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

The HIV-1 protease inhibitor indinavir impairs insulin signalling in HepG2 hepatoma cells

M. Schütt, M. Schütt, M. Meier, 2000, Diabetologia.

MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.

Guangping Chen, S. Price, J. Sands, 2008, American journal of physiology. Renal physiology.

Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension.

J. Sands, J. Klein, Young-Hee Kim, 2006, American journal of physiology. Renal physiology.

Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts.

J. Sands, Mitsi A Blount, J. Klein, 2016, American journal of physiology. Renal physiology.

muscle skeletal expression: cell proliferative reaction in mouse Electroacupuncture suppresses myostatin gene

Xiaonan H. Wang, H. Yokozaki, D. Raj, 2015 .

Neuronal expression of sodium/bicarbonate cotransporter NBCn1 (SLC4A7) and its response to chronic metabolic acidosis.

J. Sands, I. Rajbhandari, H. Park, 2010, American journal of physiology. Cell physiology.

Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1.

J. Sands, Mitsi A Blount, J. Klein, 2012, American journal of physiology. Renal physiology.

miRNA‐23a/27a attenuates muscle atrophy and renal fibrosis through muscle‐kidney crosstalk

Xiaonan H. Wang, Bin Wang, S. Price, 2018, Journal of cachexia, sarcopenia and muscle.

Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane.

Baoxue Yang, J. Sands, Huiwen Ren, 2016, American journal of physiology. Renal physiology.

Urea transporters and sweat response to uremia

J. Sands, J. Bailey, J. Klein, 2016, Physiological reports.

miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease

Aiqing Zhang, Lin Tan, Jie Du, 2019, Theranostics.

Activation of Na+/H+ Exchanger NHE3 by Angiotensin II Is Mediated by Inositol 1,4,5-Triphosphate (IP3) Receptor-binding Protein Released with IP3 (IRBIT) and Ca2+/Calmodulin-dependent Protein Kinase II*

C. Yun, C. Yun, Peijian He, 2010, The Journal of Biological Chemistry.

Suppression subtractive hybridization analysis of low-protein diet- and vitamin D-induced gene expression from rat kidney inner medullary base.

Guangping Chen, J. Sands, O. Fröhlich, 2010, Physiological genomics.

RNA-seq analysis of glycosylation related gene expression in STZ-induced diabetic rat kidney inner medulla

Zhengyu Guo, Peng Yu, Xiang Song, 2015, Front. Physiol..

N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct.

J. Sands, J. Klein, S. Steele, 2011, American journal of physiology. Renal physiology.

Glucagon infusion alters the hyperpolarized 13C‐urea renal hemodynamic signature

J. Sands, C. Laustsen, Haiyun Qi, 2018, NMR in biomedicine.

Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels.

R. Stan, J. Sands, B. Thomson, 2017, Journal of the American Society of Nephrology : JASN.

Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.

H. Fu, Yuhong Du, Guangping Chen, 2015, American journal of physiology. Renal physiology.

Downregulation of urea transporter UTA 1 activity by 14-3-3 protein 1 2

H. Fu, Yuhong Du, Guangping Chen, 2015 .

Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.

J. Sands, J. Klein, C. Liedtke, 2010, American journal of physiology. Renal physiology.

Regulation of UT-A1-mediated transepithelial urea flux in MDCK cells.

R. Gunn, J. Sands, O. Fröhlich, 2006, American journal of physiology. Cell physiology.

Urea may regulate urea transporter protein abundance during osmotic diuresis.

J. Sands, J. Klein, Dongun Kim, 2005, American journal of physiology. Renal physiology.

Electrically stimulated acupuncture increases renal blood flow through exosome-carried miR-181.

Xiaonan H. Wang, J. Klein, 2018, American journal of physiology. Renal physiology.

Caveolin-1 directly interacts with UT-A1 urea transporter: the role of caveolae/lipid rafts in UT-A1 regulation at the cell membrane.

Guangping Chen, J. Sands, Xiuyan Feng, 2009, American journal of physiology. Renal physiology.

Physiological insights into novel therapies for nephrogenic diabetes insipidus.

J. Sands, J. Klein, 2016, AJP - Renal Physiology.

Vasoconstrictors and nitrovasodilators reciprocally regulate the Na+-K+-2Cl- cotransporter in rat aorta.

W. C. O'Neill, R. Paul, J. Klein, 1999, The American journal of physiology.

Glucocorticoids mediate a decrease in AVP-regulated urea transporter in diabetic rat inner medulla.

S. Price, J. Sands, J. Bailey, 1997, American journal of physiology. Renal physiology.

Urine concentration in the diabetic mouse requires both urea and water transporters.

J. Sands, Mitsi A Blount, J. Klein, 2013, American journal of physiology. Renal physiology.

Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis.

J. Sands, H. Kwon, Hyun-wook Lee, 2009, American journal of physiology. Renal physiology.

Adrenalectomy Blocks the Compensatory Increases in UT-A1 and AQP2 in Diabetic Rat Kidney

J. Sands, J. Klein, S. Kozlowski, 2006, The Journal of Membrane Biology.

Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3.

J. Sands, Mitsi A Blount, J. Klein, 2016, Journal of the American Society of Nephrology : JASN.

Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct.

J. Sands, J. Klein, Christopher F. Martin, 2012, American journal of physiology. Renal physiology.

Phosphorylation of UTA 1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells

J. Sands, O. Fröhlich, Mitsi A Blount, 2010 .

Protein kinase C&agr; deletion causes hypotension and decreased vascular contractility

A. Chapman, R. Hoover, R. Webb, 2017, Journal of hypertension.

Corin: an ANP protease that may regulate sodium reabsorption in nephrotic syndrome.

J. Klein, 2010, Kidney international.

Downregulation of let-7 by Electrical Acupuncture Increases Protein Synthesis in Mice

Xiaonan H. Wang, J. Klein, A. Kuma, 2021, Frontiers in Physiology.

ductspermeability in mouse inner medullary collecting

J. Sands, J. Klein, Yanhua Wang, 2016 .

Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.

J. Sands, S. Wall, Mitsi A Blount, 2009, Journal of the American Society of Nephrology : JASN.

Candesartan Differentially Regulates Epithelial Sodium Channel in Cortex Versus Medulla of Streptozotocin-Induced Diabetic Rats.

C. Ecelbarger, J. Sands, S. Tiwari, 2009, Journal of epithelial biology & pharmacology.

Candesartan augments compensatory changes in medullary transport proteins in the diabetic rat kidney.

S. Price, J. Sands, Mitsi A Blount, 2008, American journal of physiology. Renal physiology.

Activation of protein kinase C-α and Src kinase increases urea transporter A1 α-2, 6 sialylation.

Baoxue Yang, Guangping Chen, J. Sands, 2015, Journal of the American Society of Nephrology : JASN.

Decreased miR-29 suppresses myogenesis in CKD.

W. Mitch, Fude Fang, Zhaoyong Hu, 2011, Journal of the American Society of Nephrology : JASN.

Urea transport in the kidney.

J. Sands, Mitsi A Blount, J. Klein, 2011, Comprehensive Physiology.

Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension.

J. Sands, Mitsi A Blount, J. Klein, 2012, American journal of physiology. Renal physiology.

MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.

Guangping Chen, J. Sands, J. Klein, 2008, American journal of physiology. Renal physiology.

Molecular mechanisms of urea transport in health and disease

J. Sands, Mitsi A Blount, J. Klein, 2012, Pflügers Archiv - European Journal of Physiology.

Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells.

J. Sands, Mitsi A Blount, J. Klein, 2010, American journal of physiology. Renal physiology.

Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus.

J. Sands, Huiwen Ren, J. Klein, 2016, JCI insight.

Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus.

R. Walker, J. Sands, J. Leader, 2008, American journal of physiology. Renal physiology.

Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct.

J. Sands, J. Klein, Christopher F. Martin, 2012, American journal of physiology. Renal physiology.

Effect of Dapagliflozin Treatment on Fluid and Electrolyte Balance in Diabetic Rats

Juan Wang, J. Sands, J. Klein, 2016, The American journal of the medical sciences.

Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein.

Kumar Sharma, James B Hoying, Jeff M Sands, 2006, American journal of physiology. Renal physiology.