Y. Kosuge

发表

Expression of microsomal prostaglandin E synthase-1 in the spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis.

K. Ishige, Yoshihisa Ito, Hiroko Miyagishi, 2012, Journal of pharmacological sciences.

Indirubin derivatives protect against endoplasmic reticulum stress-induced cytotoxicity and down-regulate CHOP levels in HT22 cells.

Shunsuke Kobayashi, S. Ohashi, K. Ishige, 2017, Bioorganic & medicinal chemistry letters.

Indirubin derivatives alter DNA binding activity of the transcription factor NF-Y and inhibit MDR1 gene promoter.

Toru Tanaka, Shunsuke Kobayashi, S. Ohashi, 2014, European journal of pharmacology.

Mithramycin, an agent for developing new therapeutic drugs for neurodegenerative diseases.

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2013, Journal of pharmacological sciences.

Comparative study of endoplasmic reticulum stress-induced neuronal death in rat cultured hippocampal and cerebellar granule neurons

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2006, Neurochemistry International.

Neuroprotective mechanisms of S-allyl-L-cysteine in neurological disease

Y. Kosuge, 2019, Experimental and therapeutic medicine.

In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1

H. Sone, K. Kosaki, J. Yonemoto, 2010, Proceedings of the National Academy of Sciences.

Preventive effect of rebamipide on NSAID-induced lower gastrointestinal tract injury using FAERS and JADER

Y. Kosuge, Shinichiro Suzuki, T. Imai, 2022, Scientific Reports.

Relevance of the hippocampal endoplasmic reticulum stress response in a mouse model of chronic kidney disease

S. Shimba, T. Wada, K. Ishige, 2018, Neuroscience Letters.

Neuroprotective effect of mithramycin against endoplasmic reticulum stress-induced neurotoxicity in organotypic hippocampal slice cultures

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2011, Neuropharmacology.

Characterization of neuronal and astroglial responses to ER stress in the hippocampal CA1 area in mice following transient forebrain ischemia

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2010, Neurochemistry International.

Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition.

M. Makishima, S. Shimba, T. Uchiyama, 2016, Journal of pharmacological sciences.

Protective effect of S-allyl-l-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain

M. Makishima, K. Ishige, Yoshihisa Ito, 2013, Amino Acids.

Apolipoprotein E-deficient mice are more vulnerable to ER stress after transient forebrain ischemia

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2009, Neurochemistry International.

Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells

Tetsuro Oda, K. Ishige, Yoshihisa Ito, 2008, Neuroscience Research.

Role of caspase-12 in amyloid beta-peptide-induced toxicity in organotypic hippocampal slices cultured for long periods.

J. Waddington, H. Ikeda, N. Koshikawa, 2007, Journal of pharmacological sciences.

Amyloid β-protein potentiates tunicamycin-induced neuronal death in organotypic hippocampal slice cultures

K. Ishige, Y. Kosuge, Y. Ito, 2007, Neuroscience.

Present State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons

Y. Kosuge, Hiroshi Nango, 2021, Cellular and Molecular Neurobiology.

Pathophysiological role of prostaglandin E2-induced up-regulation of the EP2 receptor in motor neuron-like NSC-34 cells and lumbar motor neurons in ALS model mice

K. Ishige, Yoshihisa Ito, Hiroko Miyagishi, 2017, Neurochemistry International.

Generation of Cellular Reactive Oxygen Species by Activation of the EP2 Receptor Contributes to Prostaglandin E2-Induced Cytotoxicity in Motor Neuron-Like NSC-34 Cells

K. Ishige, Yoshihisa Ito, H. Kasai, 2020, Oxidative medicine and cellular longevity.

Characterization of Motor Neuron Prostaglandin E2 EP3 Receptor Isoform in a Mouse Model of Amyotrophic Lateral Sclerosis.

K. Ishige, Yoshihisa Ito, Hiroko Miyagishi, 2015, Biological & pharmaceutical bulletin.

Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2009, Neuroscience Letters.

A Metal-Free, Disulfide Oxidized Form of Superoxide Dismutase 1 as a Primary Misfolded Species with Prion-Like Properties in the Extracellular Environments Surrounding Motor Neuron-Like Cells

Y. Kosuge, Masahisa Inoue, S. Ono, 2021, International journal of molecular sciences.

S-allyl-l-cysteine selectively protects cultured rat hippocampal neurons from amyloid β-protein- and tunicamycin-induced neuronal death

K. Ishige, Y. Kosuge, H Saito, 2003, Neuroscience.

Protective effect of S-allyl-l-cysteine, a garlic compound, on amyloid β-protein-induced cell death in nerve growth factor-differentiated PC12 cells

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2003, Neuroscience Research.

Bidens pilosa Extract Administered after Symptom Onset Attenuates Glial Activation, Improves Motor Performance, and Prolongs Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

K. Ishige, Yoshihisa Ito, Hiroko Miyagishi, 2020, Oxidative medicine and cellular longevity.

mRNA expression and localization of LPS-induced β-defensin isoforms in rat salivary glands.

Y. Kosuge, T. Shinomiya, M. Okubo, 2014, The Bulletin of Tokyo Dental College.

Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis

D. Hirose, Yoko Tanaka, K. Ishige, 2017, Cellular and Molecular Neurobiology.

Decaturenol A and known oxalicine related meroterpenoids isolated from Penicillium decaturense RO050, and their new biological activities.

D. Hirose, Kan’ichiro Ishiuchi, Yukio Fujiwara, 2020, Bioorganic & medicinal chemistry letters.

Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development

Kan’ichiro Ishiuchi, Yukio Fujiwara, T. Makino, 2019, Phytochemistry Letters.

[Adverse drug reactions and oral disorders].

K. Sawaki, Y. Kosuge, T. Shinomiya, 2006, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

α,β-Unsaturated Carboxylic Acid Derivatives. XIV. The Synthesis and Reduction of Diels-Alder Adducts from Ethyl 3-Nitro-2-alkenoates and Cyclopentadiene

J. Yoshimura, Y. Kosuge, M. Yamaura, 1978 .

Does farm fungicide use induce azole resistance in Aspergillus fumigatus?

H. Kamata, A. Hasegawa, D. Hirose, 2015, Medical mycology.

Prostaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-34.

Kosuke Sugawa, K. Ishige, Yoshihisa Ito, 2017, Journal of pharmacological sciences.

Synthesis and biological activities of methyl oligobiosaminide and some deoxy isomers thereof.

S. Ogawa, Y. Kosuge, Y. Shibata, 1990, Carbohydrate research.

Immunohistochemical study on GABAergic system in salivary glands.

K. Sawaki, Y. Kosuge, T. Shinomiya, 2009, European journal of pharmacology.

Synthesis of potent α-glucosidase inhibitors: methyl acarviosin analogue composed of 1,6-anhydro-β-D-glucopyranose residue

T. Mizukoshi, S. Ogawa, Y. Kosuge, 1990 .

Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation

S. Shimba, K. Komiyama, M. Saito, 2011, PloS one.

Nose-to-brain/spinal cord delivery kinetics of liposomes with different surface properties.

T. Kanazawa, Hisako Ibaraki, Takumi Kurano, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Intranasal Administration of N-acetyl-L-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

T. Kanazawa, Takumi Kurano, Toyofumi Suzuki, 2022, Pharmaceutics.

Quantitative analysis of inulin distribution in the brain focused on nose-to-brain route via olfactory epithelium by reverse esophageal cannulation.

N. Suzuki, T. Kanazawa, Toyofumi Suzuki, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells

Kan’ichiro Ishiuchi, S. Kitanaka, K. Ishige, 2015, Journal of Natural Medicines.

Association Between Inappropriate Use of Over-The-Counter Drugs for Allergic Rhinitis and Side Effects on the Central Nervous system—a Cross-Sectional Survey

Rie Nakajima, Y. Kosuge, Fumiyuki Watanabe, 2022, Patient preference and adherence.

PPA_A_388226 3111..3118

Rie Nakajima, Y. Kosuge, Fumiyuki Watanabe, 2022 .

Modulation Technique of Localized Surface Plasmon Resonance of Palladium Nanospheres by Coating with Titanium Dioxide Shell for Application to Photothermal Therapy Agent

Tsuyoshi Kimura, Kosuke Sugawa, Hironobu Tahara, 2022, Nanoscale Research Letters.

Deletion of Bmal1 Prevents Diet-Induced Ectopic Fat Accumulation by Controlling Oxidative Capacity in the Skeletal Muscle

M. Makishima, K. Oishi, S. Shimba, 2018, International journal of molecular sciences.

Protective action of mithramycin against neurodegeneration and impairment of synaptic plasticity in the hippocampal CA1 area after transient global ischemia

K. Ishige, Yoshihisa Ito, Hiroko Miyagishi, 2012, Neurochemistry International.

[Verification of Learning Effects by Team-based Learning].

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2017, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Possible role of transcriptional regulation of 5-HT1A receptor in the midbrain on unadaptation to stress in mice

H. Takeda, K. Ishige, M. Tsuji, 2022, Brain Research.

In vivo neurochemical evidence that delta1-, delta2- and mu2-opioid receptors, but not mu1-opioid receptors, inhibit acetylcholine efflux in the nucleus accumbens of freely moving rats.

J. Waddington, Takehiko Shimizu, T. Saigusa, 2016, European journal of pharmacology.

Highly Efficient Conversion of Motor Neuron-Like NSC-34 Cells into Functional Motor Neurons by Prostaglandin E2

Y. Shibukawa, T. Saigusa, K. Ishige, 2020, Cells.

The Molecular Mechanisms Underlying Prostaglandin D2-Induced Neuritogenesis in Motor Neuron-Like NSC-34 Cells

T. Kanazawa, K. Ishige, Toyofumi Suzuki, 2020, Cells.

Amyloid beta-protein potentiates tunicamycin-induced neuronal death in organotypic hippocampal slice cultures.

K. Ishige, Y. Kosuge, Y. Ito, 2007, Neuroscience.

Prostaglandin E2-induced cell death is mediated by activation of EP2 receptors in motor neuron-like NSC-34 cells.

K. Ishige, Yoshihisa Ito, Hiroko Miyagishi, 2013, Journal of pharmacological sciences.

Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells

Kan’ichiro Ishiuchi, S. Kitanaka, K. Ishige, 2015, Journal of Natural Medicines.

Subregion-specific vulnerability to endoplasmic reticulum stress-induced neurotoxicity in rat hippocampal neurons

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2008, Neurochemistry International.

Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis

T. Saigusa, Hiroko Miyagishi, Y. Kosuge, 2023, Translational Neurodegeneration.

Photothermal therapeutic ability of copper open-shell nanostructures that are effective in the second biological transparency window based on symmetry breaking-induced plasmonic properties.

Tsuyoshi Kimura, Kosuke Sugawa, Hironobu Tahara, 2023, Journal of materials chemistry. B.

Activation of dopamine D4 receptors is protective against hypoxia/reoxygenation-induced cell death in HT22 cells.

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2010, Journal of pharmacological sciences.

Chemical modification of the sugar part of methyl acarviosin: synthesis and inhibitory activities of nine analogues.

T. Mizukoshi, S. Ogawa, Y. Kosuge, 1992, Carbohydrate research.

Protective effect of S-allyl-l-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain

M. Makishima, K. Ishige, Yoshihisa Ito, 2014, Amino Acids.

Anti-Inflammatory Effects of Miyako Bidens pilosa in a Mouse Model of Amyotrophic Lateral Sclerosis and Lipopolysaccharide-Stimulated BV-2 Microglia

Hiroko Miyagishi, Y. Kosuge, Hiroshi Nango, 2023, International journal of molecular sciences.

Protective effect of S-allyl-l-cysteine, a garlic compound, on amyloid β-protein-induced cell death in nerve growth factor-differentiated PC12 cells

K. Ishige, Yoshihisa Ito, Y. Kosuge, 2003, Neuroscience Research.