N. Clayton

发表

Discovery of GSK345931A: An EP(1) receptor antagonist with efficacy in preclinical models of inflammatory pain.

A. Naylor, W. Winchester, A. Hall, 2009, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists.

I. Chessell, A. Naylor, S. Atkinson, 2006, Bioorganic & medicinal chemistry letters.

Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.

I. Chessell, A. Naylor, C. O'shaughnessy, 2007 .

GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain

Richard Graham Knowles, J. Alba, P. Colthup, 2006, Pain.

Vanilloid receptor 1 expression in human tooth pulp in relation to caries and pain.

John B Davis, C. R. Morgan, F. Boissonade, 2005, Journal of orofacial pain.

Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain.

A. Naylor, W. Winchester, A. Hall, 2009, Bioorganic & medicinal chemistry letters.

Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy.

A. Naylor, A. Hall, A. Billinton, 2008, Bioorganic & medicinal chemistry letters.

1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives.

I. Chessell, A. Naylor, A. Hall, 2007, Bioorganic & medicinal chemistry letters.

1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure-activity relationships of 4- and 5-substituted benzoic acid derivatives.

I. Chessell, A. Naylor, A. Hall, 2007, Bioorganic & medicinal chemistry letters.

The effect of the novel sodium channel blocker 4030W92 in models of acute and chronic inflammatory pain in the rat

C. Bountra, D. Trezise, N. Clayton, 1998 .

CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain

F. Marshall, C. O'shaughnessy, C. Bountra, 2002, Pain.

Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.

I. Wall, I. Chessell, A. Naylor, 2009, Bioorganic & medicinal chemistry letters.

Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat

V. Chapman, D. Kendall, S. Medhurst, 2005, Pain.

P2X3 expression is not altered by lingual nerve injury

J. E. Biggs, J. Yates, F. Boissonade, 2008, Neuroscience Letters.

Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.

Michael A. Briggs, I. Chessell, A. Naylor, 2009, Journal of medicinal chemistry.

Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.

I. Chessell, A. Naylor, C. O'shaughnessy, 2007, Journal of medicinal chemistry.

Identification of novel pyrazole acid antagonists for the EP1 receptor.

I. Chessell, X. Lewell, A. Hall, 2006, Bioorganic & medicinal chemistry letters.

Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP4 receptor partial agonist for the treatment of pain.

I. Chessell, A. Naylor, A. Billinton, 2018, Bioorganic & medicinal chemistry letters.

Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

I. Chessell, A. Naylor, C. Bountra, 2004, Bioorganic & medicinal chemistry letters.

The effects of ibuprofen and the neurokinin‐1 receptor antagonist GR205171A on Fos expression in the ferret trigeminal nucleus following tooth pulp stimulation

C. Bountra, F. Boissonade, N. Clayton, 2008, European journal of pain.

Review article: the therapeutic potential of 5‐HT3 receptor antagonists in the treatment of irritable bowel syndrome

C. Bountra, N. Clayton, P. Humphrey, 1999, Alimentary pharmacology & therapeutics.

THE THERAPEUTIC POTENTIAL OF 5-HT3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME

C. Bountra, N. Clayton, P. Humphrey, 1999 .

The effect of inflammation on Fos expression in the ferret trigeminal nucleus.

C. Bountra, F. Boissonade, A. Loescher, 2007, European journal of oral sciences.

Validation of the dual channel weight averager as an instrument of the measurement of clinically relevant pain

S. Thompson, Alan Wheeldon, Nick M. Clayton, 1997 .

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.

I. Chessell, A. Naylor, A. Hall, 2007, Bioorganic & medicinal chemistry letters.

Effect of SB-750364, a specific TRPV1 receptor antagonist, on injury-induced ectopic discharge in the lingual nerve

J. E. Biggs, J. Yates, F. Boissonade, 2008, Neuroscience Letters.

Changes in vanilloid receptor 1 (TRPV1) expression following lingual nerve injury

J. E. Biggs, J. Yates, F. Boissonade, 2007, European journal of pain.

Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain

J. E. Biggs, J. Yates, F. Boissonade, 2007, Brain Research.

nNOS expression following inferior alveolar nerve injury in the ferret

C. Bountra, F. Boissonade, A. Loescher, 2004, Brain Research.

The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] Is Effective in Animal Models of Neuropathic Pain and Central Sensitization

S. Summerfield, I. Chessell, A. Naylor, 2005, Journal of Pharmacology and Experimental Therapeutics.

GR63799X--a novel prostanoid with selectivity for EP3 receptors.

R. A. Coleman, K. Bunce, R. Sheldrick, 1991, Advances in prostaglandin, thromboxane, and leukotriene research.

Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.

I. Chessell, S. Bingham, A. Billinton, 2008, The journal of pain : official journal of the American Pain Society.

Mechanism of stimulation of colonic secretion in the rat by the prostanoid enprostil

K. Bunce, N. Clayton, R. Stables, 1988 .

The effects of the stable thromboxane A2‐mimetic, U46619, on gastric mucosal damage and gastric non‐parietal secretion in the rat

K. Bunce, N. Clayton, 1987, British journal of pharmacology.

Increased mucosal mast cells in irritable bowel syndrome (IBS)

C. O'Morain, M. O'Sullivan, N. Breslin, 1998 .

Changes in sodium channel expression following trigeminal nerve injury

C. Bountra, F. Boissonade, A. Loescher, 2006, Experimental Neurology.

An NMR-based metabolic profiling study of inflammatory pain using the rat FCA model

C. Bountra, I. Chessell, C. Bountra, 2007, Metabolomics.

Increased mast cells in the irritable bowel syndrome

C. O'Morain, M. O'Sullivan, N. Breslin, 2000, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.

I. Chessell, C. Bountra, S. Bingham, 2009, Bioorganic & medicinal chemistry letters.

Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.

Anne Hersey, A. Hersey, G. Bravi, 2010, Bioorganic & medicinal chemistry letters.