J. del Río

发表

Antagonism of diazepam-induced feeding in rats by antisera to opioid peptides.

F. Sánchez‐Franco, Y. González, M. P. Fernandez-Tome, 1984, Life sciences.

Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: Implications for spatial memory

M. Ramírez, J. del Río, R. Tordera, 2009, Hippocampus.

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

M. Martín-Martínez, Sergio A Alonso de Diego, M. García-López, 2005, Bioorganic & medicinal chemistry letters.

Effect of neuroleptics and of combinations of d-amphetamine and neuroleptics on 3H-dopamine uptake by homogenates from rat striatum.

J. del Río, J. Madroñal, 1976, European journal of pharmacology.

Action of peptidase inhibitors on methionine5-enkephalin-arginine6-phenylalanine7 (YGGFMRF) and methionine5-enkephalin (YGGFM) metabolism and on electroacupuncture antinociception.

H. Y. Yang, E. Costa, J. del Río, 1984, The Journal of pharmacology and experimental therapeutics.

Implanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum.

R. Insausti, J. Almendral, A. García-Osta, 2000, Brain research. Molecular brain research.

Effect of p‐Chloroamphetamine on 5‐HT1A and 5‐HT7 Serotonin Receptor Expression in Rat Brain

A. García-Osta, J. del Río, D. Frechilla, 2000, Journal of neurochemistry.

Antidepressants selectively antagonize the hyperactivity induced in rats by long-term isolation.

J. Garzón, J. del Río, J. Fuentes, 1979, European journal of pharmacology.

Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau

J. Ávila, F. Hernández, I. Santa-Maria, 2007, Molecular Neurodegeneration.

Hyperactivity induced in rats by long-term isolation: further studies on a new animal model for the detection of antidepressants.

J. Garzón, J. del Río, J. Garzón, 1981, European journal of pharmacology.

Gangliosides and parkinsonism

Y. Agid, J. Obeso, M. Herrero, 1993, Neurology.

Synthesis and analgesic properties of N-phosphorylated derivatives of Phe-Ala and Phe-Gly.

M. García-López, J. Naranjo, R. Herranz, 2009, International journal of peptide and protein research.

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structural modifications at the tryptophan domain.

M. Martín-Martínez, J. Bartolomé-Nebreda, I. Gomez-Monterrey, 1999, Journal of medicinal chemistry.

Down-regulation of 3H-imipramine binding sites in rat cerebral cortex after prenatal exposure to antidepressants.

M. L. de Ceballos, J. del Río, D. Montero, 1990, Life sciences.

Pharmacological evaluation of IQM‐95,333, a highly selective CCKA receptor antagonist with anxiolytic‐like activity in animal models

M. Martín-Martínez, I. Gomez-Monterrey, M. García-López, 1997, British journal of pharmacology.

Nitro-oleic Acid, a Novel and Irreversible Inhibitor of Xanthine Oxidoreductase*

M. Tarpey, B. Freeman, Nicholas J. Hundley, 2008, Journal of Biological Chemistry.

Characterization of serotonergic mechanisms involved in the behavioural inhibition induced by 5-hydroxytryptophan in a modified light-dark test in mice.

J. del Río, I. Artaiz, A. Zazpe, 1998, Behavioural pharmacology.

Pharmacological Study of IQM-97,423, a Potent and Selective CCK1 Receptor Antagonist with Protective Effect in Experimental Acute Pancreatitis

J. Bartolomé-Nebreda, M. García-López, R. González-Muñiz, 2004, Pharmacology.

Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity.

M. Ramírez, J. del Río, B. Lasheras, 1999, Neuroreport.

GABA(A) receptor antagonists enhance cortical acetylcholine release induced by 5-HT(3) receptor blockade in freely moving rats.

M. Garcia-Alloza, M. Ramírez, J. del Río, 2002, Brain research.

Striatal homovanillic acid levels in rats after combined treatments with amphetamine and neuroleptics.

J. del Río, J. Fuentes, 1972, European journal of pharmacology.

Effects of thiophene analogues of chloroamphetamines on central serotonergic mechanisms.

S. Conde, M. P. Fernandez-Tome, J. del Río, 1978, Journal of medicinal chemistry.

New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.

A. Monge, M Mourelle, S. Pérez-Silanes, 2001, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism.

A. Monge, J. del Río, R. Tordera, 2000, Farmaco.

5-(tryptophylamino)-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based cholecystokinin receptor antagonists: reversal of CCK1 receptor subtype selectivity toward CCK2 receptors.

M. García-López, D. Fourmy, M. Dufresne, 2004, Journal of medicinal chemistry.

Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.

M. Martín-Martínez, J. Bartolomé-Nebreda, I. Gomez-Monterrey, 1997, Journal of medicinal chemistry.

Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives.

A. Monge, J. del Río, J. Palop, 1993, Journal of medicinal chemistry.

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.

J. Bartolomé-Nebreda, M. García-López, R. González-Muñiz, 2001, Journal of medicinal chemistry.

NMDA receptor subunit and CaMKII changes in rat hippocampus induced by acute MDMA treatment: a mechanism for learning impairment

J. del Río, D. Frechilla, S. Moyano, 2004, Psychopharmacology.

Aminopeptidase Inhibitory Properties and Analgesic Activity of (2S,3,7‐3,7‐Diamino‐2‐hydroxy‐heptanoic Acid Containing Tripeptide Analogues of the N‐Terminal Tripeptide of Probestin

M. L. de Ceballos, M. García-López, C. Pérez, 1992, Archiv der Pharmazie.

Conformationally restricted PACAP27 analogues incorporating type II/II' IBTM beta-turn mimetics. Synthesis, NMR structure determination, and binding affinity.

M. Martín-Martínez, M. García-López, R. González-Muñiz, 2001, Bioorganic & medicinal chemistry.

Analgesic activity of substance P in rats: tolerance and cross-tolerance with enkephalin.

J. Naranjo, M. P. Fernandez-Tome, J. del Río, 1984, European journal of pharmacology.

The role of dopaminergic systems in the perinatal sensitivity to 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in rats.

J. del Río, J. Rı́o, B. Lasheras, 1998, The Journal of pharmacology and experimental therapeutics.

Further studies on the antagonism of stereotyped behaviour induced by amphetamine.

J. del Río, J. Fuentes, 1969, European journal of pharmacology.

Analgesic activity of substance P in rats: apparent mediation by met-enkephalin release.

J. Naranjo, F. Sánchez‐Franco, J. Garzón, 1982, Life sciences.

Differential effects of D-Ala2 analogues of enkephalins on substance P-induced analgesia in rodents.

J. Naranjo, J. del Río, 1982, European journal of pharmacology.

Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.

M. Martín-Martínez, M. García-López, R. González-Muñiz, 1999, Bioorganic & medicinal chemistry letters.

Fever, antipyretics and serum iron levels in rabbits.

J. del Río, A. Cremades, A. Brugger, 1982, European journal of pharmacology.

Ketomethylene Analogues of Phosphoryl Dipeptides Related to Phosphoramidon: Synthesis and Inhibition of Proteases

I. Gomez-Monterrey, J. del Río, R. González Muñiz, 1992, Archiv der Pharmazie.

Long-term hyperalgesia in rats induced by neonatal administration of vasopressin antiserum.

R. Moratalla, F. Sánchez‐Franco, J. del Río, 1986, Life sciences.

N-substituted 2-amino-1-(2-thienyl)ethanols as beta-adrenergic blocking agents.

V. Darias, M. P. Fernandez-Tome, J. del Río, 1973, Journal of medicinal chemistry.

Serotonin 5‐HT1A receptor expression is selectively enhanced in the striosomal compartment of chronic parkinsonian monkeys

R. Insausti, R. Moratalla, A. Cobreros, 2001, Synapse.

Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.

Jesús Avila, J. Ávila, A. Ricobaraza, 2009, Journal of Alzheimer's Disease.

Flumazenil and tacrine increase the effectiveness of ondansetron on scopolamine-induced impairment of spatial learning in rats

M. Garcia-Alloza, M. Ramírez, J. del Río, 2003, Psychopharmacology.

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

L. Pardo, A. Planas, J. Ramos, 2011, Journal of medicinal chemistry.

Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors.

A. Monge, J. del Río, R. Tordera, 2002, European journal of pharmacology.

Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer's disease transgenic mice: an insight into the pathogenic effects of amyloid-β.

J. del Río, Alberto Pérez-Mediavilla, D. Frechilla, 2011, Journal of Alzheimer's disease : JAD.

Prenatal exposure of rats to antidepressants enhances agonist affinity of brain dopamine receptors and dopamine-mediated behaviour.

M. L. de Ceballos, C. de Felipe, J. del Río, 1985, European journal of pharmacology.

Serotonin 5‐HT1A receptor blockade enhances Ca2+/calmodulin‐dependent protein kinase II function and membrane expression of AMPA receptor subunits in the rat hippocampus: implications for memory formation

L. Schiapparelli, J. del Río, D. Frechilla, 2005, Journal of neurochemistry.

Pharmacological characteristics and regulation of 5-HT receptor-stimulated phosphoinositide hydrolysis in the rat spinal cord.

J. del Río, E. Toscano, C. Oset, 1999, General pharmacology.

Acute or chronic antidepressants do not modify [125I]cyanopindolol binding to 5-HT1B receptors in rat brain.

J. del Río, D. Montero, M. D. de Felipe, 1991, European journal of pharmacology.

Increased dopamine receptor binding in the striatum of rats after long-term isolation.

J. del Río, P. Fernández-Tomé, E. Guisado, 1980, European journal of pharmacology.

MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion.

J. del Río, S. Ballaz, B. Lasheras, 1998, European journal of pharmacology.

Differential Regulation by Methylenedioxymethamphetamine of 5‐Hydroxytryptamine1A Receptor Density and mRNA Expression in Rat Hippocampus, Frontal Cortex, and Brainstem: The Role of Corticosteroids

A. García-Osta, J. del Río, B. Lasheras, 1997, Journal of neurochemistry.

Methylenedioxymethamphetamine induces opposite changes in central pre- and postsynaptic 5-HT1A receptors in rats.

J. Galbete, J. del Río, B. Lasheras, 1995, European journal of pharmacology.

Naloxone blocks the effect of 5-hydroxy-tryptophan on passive avoidance learning in rats: implication of endogenous opiod peptides.

J. Rubio, J. Garzón, J. del Río, 1981, Life sciences.

Memory and neurogenesis in aging and Alzheimer's disease.

R. Insausti, J. Ávila, J. del Río, 2010, Aging and disease.

Co-induction of jun B and c-fos in a subset of neurons in the spinal cord.

J. Lucas, P. Sassone-Corsi, B. Mellström, 1991, Oncogene.

Increased CRE-binding activity and tryptophan hydroxylase mRNA expression induced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rat frontal cortex but not in the hippocampus.

A. García-Osta, J. del Río, D. Frechilla, 2004, Brain research. Molecular brain research.

Effect of prenatal exposure to antidepressants on 5-HT-stimulated phosphoinositide hydrolysis and 5-HT2 receptors in rat brain.

J. del Río, E. Toscano, G. Romero, 1994, General pharmacology.

Regulation of markers of synaptic function in mouse models of depression: chronic mild stress and decreased expression of VGLUT1

T. Sharp, A. L. Garcia-Garcia, M. Ramírez, 2010, Journal of neurochemistry.

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

M. Martín-Martínez, M. García-López, R. González-Muñiz, 2006, Bioorganic & medicinal chemistry letters.

Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs.

Rebeca Martínez-Turrillas, J. del Río, D. Frechilla, 2007, Biochemical and biophysical research communications.

Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model.

J. del Río, Alberto Pérez-Mediavilla, D. Frechilla, 2009, Biochemical and biophysical research communications.

BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons

A. García-Osta, E. Cenarruzabeitia, J. del Río, 2001, Neuroreport.

Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.

Mercedes Martín-Martínez, M. Martín-Martínez, M. García-López, 2005, Journal of medicinal chemistry.

New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants.

A. Monge, M Mourelle, A Monge, 2001, European journal of medicinal chemistry.

Facilitation by 8‐OH‐DPAT of passive avoidance performance in rats after inactivation of 5‐HT1A receptors

A. García-Osta, J. del Río, S. Ballaz, 1999, British journal of pharmacology.

New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.

M. García-López, R. González-Muñiz, C. Cativiela, 2006, Bioorganic & medicinal chemistry letters.

[Perspectives on the amyloid cascade hypothesis of Alzheimer's disease].

J. del Río, D. Frechilla, Ana-María Simón, 2010, Revista de neurologia.

Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.

A. Monge, J. del Río, J. Palop, 1994, Journal of medicinal chemistry.

Neurotoxic effect of prenatal exposure to MPTP on the dopaminergic systems of the marmoset brain.

A. Kupsch, W. Oertel, J. Obeso, 1992, European journal of pharmacology.

Synthesis and biological properties of beta-turned Abeta(31-35) constrained analogues.

M. García-López, R. González-Muñiz, D. Andreu, 2008, Bioorganic & medicinal chemistry letters.

Possible mechanisms implicated on the hypothermic effect induced by morphine in guinea-pig.

M. Milanés, J. del Río, A. Cremades, 1984, General pharmacology.

Analgesic dipeptide derivatives. 4. Linear and cyclic analogues of the analgesic compounds arginyl-2-[(o-nitrophenyl)sulfenyl]tryptophan and lysyl-2-[(o-nitrophenyl)sulfenyl]tryptophan.

M. García-López, R. González-Muñiz, J. del Río, 1988, Journal of medicinal chemistry.

Analgesic dipeptide derivatives. 3. Synthesis and structure-activity relationships of o-nitrophenyl-modified analogues of the analgesic compound H-Lys-Trp(NPS)-OMe.

M. García-López, R. González-Muñiz, J. Naranjo, 1987, Journal of medicinal chemistry.

Serotonin 5-HT1A receptor activation prevents phosphorylation of NMDA receptor NR1 subunit in cerebral ischemia

J. del Río, D. Frechilla, P. Salazar-Colocho, 2007, Journal of Physiology and Biochemistry.

Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.

M. Martín-Martínez, M. García-López, R. González-Muñiz, 2002, Bioorganic & medicinal chemistry letters.

Benzimidazole derivatives. Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

M. López-Rodríguez, B. Benhamú, L. Schiapparelli, 2004, Bioorganic & medicinal chemistry.

Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

M. López-Rodríguez, B. Benhamú, L. Schiapparelli, 2003, Bioorganic & medicinal chemistry letters.