Kai Wang

发表

Lipoprotein‐associated phospholipase A2: The story continues

Jianhua Shen, F. Huang, Kai Wang, 2019, Medicinal research reviews.

Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema.

Jianhua Shen, Yi-ping Wang, Kai Wang, 2016, Journal of medicinal chemistry.

Design, synthesis and structure−activity relationship studies of GPR40 agonists containing amide linker

Jianhua Shen, Kai Wang, Meng-meng Ning, 2018 .

Design and synthesis of imidazole and triazole derivatives as Lp-PLA₂ inhibitors and the unexpected discovery of highly potent quaternary ammonium salts.

Wei Zhang, Jianhua Shen, Yang Liu, 2013, Bioorganic & medicinal chemistry letters.

Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent-Fragment-Based Approach.

Yechun Xu, Jianhua Shen, Hu Zhou, 2020, Journal of medicinal chemistry.

Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect

Jianhua Shen, Kai Wang, Meng-meng Ning, 2016, Scientific Reports.

Discovery of Highly Polar β-homophenylalanine Derivatives as Non-systemic Intestine-Targeted Dipeptidyl Peptidase IV Inhibitors.

Jianhua Shen, Jia Liu, F. Huang, 2019, Journal of medicinal chemistry.

Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation

Jianhua Shen, Zhengyu Cao, H. Tian, 2022, Bioorganic & Medicinal Chemistry.

Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis.

Jianhua Shen, H. Qu, Kai Wang, 2022, European journal of medicinal chemistry.

Quantification of microbiota-related phenols and aromatic acids in mouse feces of a diabetic nephropathy model by simultaneous BDAPE derivatization using ultra-performance liquid chromatography-tandem mass spectrometry

Jianhua Shen, Hui Xu, Jia Liu, 2020, Analytical and Bioanalytical Chemistry.

Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors.

Yechun Xu, Jianhua Shen, Xiaojing Yuan, 2015, Journal of medicinal chemistry.

Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2.

Qiufeng Liu, Jianhua Shen, Yechun Xu, 2017, Journal of medicinal chemistry.

Triazole derivatives: a series of Darapladib analogues as orally active Lp-PLA2 inhibitors.

Wei Zhang, Jianhua Shen, Yi-ping Wang, 2013, Bioorganic & medicinal chemistry letters.

Discovery of pyridazinone analogs as potent transient receptor potential canonical channel 5 inhibitors.

Jianhua Shen, Zhengyu Cao, H. Tian, 2022, Bioorganic & medicinal chemistry letters.

Magnesium lithospermate B ameliorates diabetic nephropathy by suppressing the uremic toxin formation mediated by gut microbiota.

Jia Liu, Kai Wang, Haonan Duan, 2023, European journal of pharmacology.

Discovery of Novel 5,6-Dihydro-1,2,4-triazine Derivatives as Efficacious Glucagon-Like Peptide-1 Receptor Agonists.

Jianhua Shen, Ting Zhao, Shimeng Guo, 2023, Journal of medicinal chemistry.

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonists

Jianhua Shen, Xinheng He, Junrui Li, 2023, bioRxiv.

Triazole derivatives: a series of Darapladib analogues as orally active Lp-PLA2 inhibitors.

Wei Zhang, Jianhua Shen, Yi-ping Wang, 2013, Bioorganic & medicinal chemistry letters.

A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency.

Shimeng Guo, Qianting Yuan, Kai Wang, 2024, Bioorganic & medicinal chemistry.

Conserved class B GPCR activation by a biased intracellular agonist

Jianhua Shen, Xinheng He, Junrui Li, 2023, Nature.

Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD.

Xinheng He, Shimeng Guo, Qing Zhang, 2023, Bioorganic & medicinal chemistry.