Clint Mitchell

发表

Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.

S. Milstien, S. Spiegel, P. Dent, 2009, Cancer research.

Correction to “Poly(ADP-Ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Carcinoma Cells”

P. Dent, A. Yacoub, Chen Yang, 2010 .

Poly(ADP-Ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Carcinoma Cells

P. Dent, A. Yacoub, Chen Yang, 2010, Molecular Pharmacology.

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

John D. Roberts, P. Dent, M. Hagan, 2008, Molecular Cancer Therapeutics.

Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor re-growth

John D. Roberts, P. Dent, A. Yacoub, 2005, Cancer biology & therapy.

Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3β androstene 17α diol neuro-steroid on malignant glioma cells

P. Dent, R. Loria, W. Jia, 2009, The Journal of Steroid Biochemistry and Molecular Biology.

17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

P. Fisher, D. Häussinger, P. Dent, 2010, Molecular Cancer Therapeutics.

Molecular Cancer Therapeutics 17-Allylamino-17-Demethoxygeldanamycin and MEK 1 / 2 Inhibitors Kill GI Tumor Cells via Ca 2 +-Dependent Suppression of GRP 78 / BiP and Induction of Ceramide and Reactive Oxygen Species

P. Fisher, D. Häussinger, P. Dent, 2010 .

PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.

P. Fisher, S. Spiegel, P. Dent, 2010, Cancer research.

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

P. Dent, A. Yacoub, S. Grant, 2007, Molecular Cancer Therapeutics.

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

John D. Roberts, P. Fisher, P. Dent, 2008, Clinical Cancer Research.

Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo

K. Nephew, P. Dent, A. Yacoub, 2010, Cancer biology & therapy.

Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

K. Nephew, P. Dent, S. Grant, 2009, Cancer biology & therapy.

Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death.

Clint Mitchell, R. Mckallip, Andrew R. Joyce, 2010, Toxicology letters.

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

John D. Roberts, P. Fisher, P. Dent, 2007, Molecular Cancer Therapeutics.

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

P. Fisher, P. Dent, M. Hagan, 2008, Molecular Cancer Therapeutics.

Primary Human Glioblastoma Multiforme Cells Induced Killing of −-7 / IL-24 mda Thioredoxin Play a Key Role in Dependent Regulation of Ceramide Synthase 6 and −

P. Fisher, S. Spiegel, P. Dent, 2010 .

Conjugated Bile Acids Regulate Hepatocyte Glycogen Synthase Activity In Vitro and In Vivo via Gαi Signaling

P. Dent, S. Grant, W. Pandak, 2007, Molecular Pharmacology.

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes

S. Spiegel, P. Dent, Clint Mitchell, 2005, Hepatology.

Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling*

P. Fisher, P. Dent, S. Grant, 2008, Journal of Biological Chemistry.

A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels

P. Fisher, S. Spiegel, P. Dent, 2011, Molecular Pharmacology.

Low-Dose BBR3610 Toxicity in Colon Cancer Cells Is p53-Independent and Enhanced by Inhibition of Epidermal Growth Factor Receptor (ERBB1)-Phosphatidyl Inositol 3 Kinase Signaling

John D. Roberts, P. Fisher, P. Dent, 2007, Molecular Pharmacology.

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

P. Dent, Anindita Das, Margaret A. Park, 2010, Proceedings of the National Academy of Sciences.

Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95

S. Batra, P. Dent, Anindita Das, 2015, Oncotarget.

Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation

P. Fisher, P. Dent, M. Hagan, 2008, Molecular Pharmacology.

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

P. Fisher, S. Spiegel, K. Ryan, 2008, Cancer biology & therapy.

MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.

W. Linehan, P. Fisher, P. Dent, 2003, Molecular cancer therapeutics.

H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.

P. Dent, M. Hagan, A. Yacoub, 2005, Molecular cancer therapeutics.

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.

P. Dent, S. Grant, M. Rahmani, 2005, Blood.

INTERRUPTION OF BOTH AKT AND MEK / ERK PATHWAYS AND ACTIVATION OF SEK 1 / JNK

P. Dent, S. Grant, M. Rahmani, 2004 .

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.

G. Mills, P. Wipf, P. Dent, 2009, Cancer research.

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.

P. Fisher, S. Spiegel, D. Häussinger, 2010, Cancer research.

Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death

P. Dent, A. Yacoub, S. Grant, 2011, Cancer biology & therapy.

Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes

P. Dent, S. Grant, S. Han, 2004, Hepatology.

MDA-7 regulates cell growth and radiosensitivity in vitro of primary (Non-Established) human glioma cells

P. Fisher, P. Dent, A. Yacoub, 2004, Cancer biology & therapy.

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.

J. Grandis, P. Dent, A. Yacoub, 2005, Biochemical pharmacology.

Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo.

P. Fisher, P. Dent, A. Yacoub, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

mda-7 (IL-24) Inhibits Growth and Enhances Radiosensitivity of Glioma Cells In Vitro via JNK Signaling

P. Fisher, P. Dent, A. Yacoub, 2003, Cancer biology & therapy.

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

P. Houghton, P. Dent, A. Yacoub, 2009, Molecular Pharmacology.

BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing

A. Thorburn, D. Häussinger, P. Dent, 2009, Molecular Pharmacology.

OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells

P. Dent, A. Yacoub, S. Grant, 2006, Molecular Pharmacology.

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

P. Dent, M. Hagan, A. Yacoub, 2005, Molecular cancer therapeutics.

Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo

P. Dent, A. Yacoub, S. Grant, 2008, Cancer biology & therapy.

Radiation-Stimulated ERK1/2 and JNK1/2 Signaling can Promote Cell Cycle Progression in Human Colon Cancer Cells

P. Dent, M. Hagan, A. Yacoub, 2005, Cell cycle.