J. Huffman

发表

Inhibition of tumor angiogenesis by cannabinoids

A. Planas, J. Jorcano, J. Aragonés, 2002 .

Paradoxical Pharmacological Effects of Deoxy-Tetrahydrocannabinol Analogs Lacking High CB1 Receptor Affinity

J. Liddle, G. Griffin, B. Martin, 2002, Pharmacology.

Structure–activity relationships for 1′,1′-dimethylalkyl-Δ 8 -tetrahydrocannabinols

John R. Miller, J. Liddle, B. Thomas, 2003 .

A pyridone analogue of traditional cannabinoids. A new class of selective ligands for the CB(2) receptor.

G. Hynd, B. Martin, J. Wiley, 2001, Bioorganic & medicinal chemistry.

Theoretical and experimental estimates of the acetylenic deuteron quadrupole coupling constant

H. G. Spencer, R. V. Gregory, J. Huffman, 1987 .

The search for selective ligands for the CB2 receptor.

J W Huffman, J. Huffman, 2000, Current pharmaceutical design.

The Spicy Story of Cannabimimetic Indoles

B. Thomas, A. Howlett, J. Huffman, 2021, Molecules.

Hijacking of Basic Research: The Case of Synthetic Cannabinoids.

B. Thomas, J. Wiley, R. Balster, 2011, Methods report.

Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940.

B. Martin, J. Wiley, J. Huffman, 2008, Bioorganic & medicinal chemistry.

Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for the cannabinoid CB2 receptor.

B. Martin, J. Wiley, Karla-Sue C. Marriott, 2006, Bioorganic & medicinal chemistry.

Enantioselective synthesis of 1-methoxy- and 1-deoxy-2'-methyl-delta8-tetrahydrocannabinols: new selective ligands for the CB2 receptor.

B. Martin, J. Wiley, S. Bushell, 2006, Bioorganic & medicinal chemistry.

1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles.

D. Selley, B. Martin, J. Wiley, 2005, Bioorganic & medicinal chemistry letters.

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

G. Hynd, D. Selley, Ming-Jung Wu, 2005, Bioorganic & medicinal chemistry.

The metal-ammonia reduction of ketones

J. Huffman, J. Charles, 1968 .

Delayed female sexual maturation. How to approach differential diagnosis.

J. Huffman, 1985, Postgraduate medicine.

Menstrual problems of the adolescent.

J. Huffman, 1955, Pediatric clinics of North America.

Cannabinoid‐2 receptor mediates protection against hepatic ischemia/reperfusion injury

H. Pan, D. Osei-Hyiaman, P. Pacher, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.

M. L. de Ceballos, G. Velasco, S. Y. Cajal, 2001, Cancer research.

Structure-activity relationships of indole- and pyrrole-derived cannabinoids.

D. R. Compton, B. Martin, J. Wiley, 1998, The Journal of pharmacology and experimental therapeutics.

Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes.

L. Padgett, J. Huffman, 2005, Current medicinal chemistry.

The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor.

J. Murphy, D. Kendall, C. Chin, 1999, The Journal of pharmacology and experimental therapeutics.

3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor.

Ming-Jung Wu, B. Martin, J. Wiley, 2003, Bioorganic & medicinal chemistry.

CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.

K. Mackie, Z. Ungvari, A. Csiszar, 2007, American journal of physiology. Heart and circulatory physiology.

Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding.

Ming-Jung Wu, G. Griffin, B. Martin, 2000, Drug and alcohol dependence.

The influence of beta-arrestin2 on cannabinoid CB1 receptor coupling to G-proteins and subcellular localization and relative levels of beta-arrestin1 and 2 in mouse brain

C. Breivogel, R. Razdan, J. Lambert, 2013, Journal of receptor and signal transduction research.

Metal-ammonia reductions of cyclic aliphatic ketones

J. Huffman, 1983 .

ADENOCARCINOMA OF THE FEMALE URETHRA

J. Huffman, L. Walker, 2011 .

Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration.

S. Welch, J. Huffman, Rene Anikwue, 2002, The Journal of pharmacology and experimental therapeutics.

Decrease in Efficacy and Potency of Nonsteroidal Anti- Inflammatory Drugs by Chronic -Tetrahydrocannabinol Administration

S. Welch, J. Huffman, Rene Anikwue, 2002 .

The effect of gynecologic surgery on sexual reactions

J. Huffman, 1950 .

Stereoselective total synthesis of (.+-.)-isocelorbicol

J. Huffman, P. Raveendranath, 1987 .

SYNTHETIC APPROACHES TO POLYHYDROXYAGAROFURANS

J. Huffman, G. F. Hillenbrand, 1981 .

Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents.

B. Martin, J. Wiley, V. Smith, 2012, Bioorganic & medicinal chemistry.

Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.

B. Martin, J. Wiley, D. Hurst, 2010, Bioorganic & medicinal chemistry.

1-Methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Delta(8)-tetrahydrocannabinols: new selective ligands for the CB2 receptor.

John R. Miller, B. Martin, J. Wiley, 2002, Bioorganic & medicinal chemistry.

CB2 cannabinoid receptor stimulation attenuates TNF‐alpha‐induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte‐endothelial adhesion.

Z. Ungvari, A. Csiszar, P. Pacher, 2008 .

1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-Δ(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.

D. Selley, B. Martin, J. Wiley, 2010, Bioorganic & medicinal chemistry.

Cannabimimetic Indoles, Pyrroles, and Indenes: Structure–Activity Relationships and Receptor Interactions

J. Huffman, 2009 .

1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.

B. Martin, J. Wiley, L. Padgett, 2006, Bioorganic & medicinal chemistry letters.

Structure-Activity Relationships of Indole-and Pyrrole-Derived Cannabinoids 1

D. R. Compton, B. Martin, J. Wiley, 1998 .

Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals.

S. Yu, R. Pertwee, G. Griffin, 1997, European journal of pharmacology.

1-Alkyl-3-(1-naphthoyl)pyrroles: A New Class of Cannabinoid.

D. R. Compton, B. Martin, J. Huffman, 1995 .

Sensitivity to Δ9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2−/− mice

C. Breivogel, R. Razdan, J. Lambert, 2008, Behavioural pharmacology.

GPR55 in the CNS

K. Mackie, Hui-Chen Lu, J. Huffman, 2013 .

Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens.

G. Griffin, R. Pertwee, J. Huffman, 1995, European journal of pharmacology.

1-ALKYL-3-(1-NAPHTHOYL)PYRROLES : A NEW CLASS OF CANNABINOID

D. R. Compton, B. Martin, J. Huffman, 1995 .

Synthesis and pharmacology of a hybrid cannabinoid.

B. Martin, J. Wiley, J. Huffman, 2000, Bioorganic & medicinal chemistry.

Discriminative stimulus properties of Δ 9 -Tetrahydrocannabinol (THC) in C57BL/6J mice

J. Warner, B. Martin, J. Wiley, 2009 .

Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists.

R. Razdan, B. Martin, B. Saha, 1999, The Journal of pharmacology and experimental therapeutics.

Pharmacological specificity of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rhesus monkeys.

B. Martin, J. Wiley, R. Balster, 1995, Drug and alcohol dependence.

Synthesis and pharmacology of the isomeric methylheptyl-Δ8-tetrahydrocannabinols

J. Liddle, B. Martin, J. Wiley, 1998 .

Side chain methyl analogues of Δ8-THC

D. R. Compton, B. Martin, J. Wiley, 1997 .

The time has come; a Catholic doctor's proposals to end the battle over birth control.

J. Huffman, 1963 .

Synthesis of (.+-.)-11-nor-9-carboxy-.DELTA.9-tetrahydrocannabinol. New synthetic approaches to cannabinoids

Ming-Jung Wu, Xuehai Zhang, J. Huffman, 1991 .

A Very Facile SNAr Reaction with Elimination of Methoxide

Ming-Jung Wu, J. Huffman, Jianzhong Lu, 1998 .

Reduction of C X to CHXH by Dissolving Metals and Related Methods

J. Huffman, 1991 .

A silyl enol ether variation of the Robinson annulation

Shailesh M. Potnis, J. Huffman, A. V. Satish, 1985 .

Stereoselective total synthesis of (±)-isocelorbicol

J. Huffman, P. Raveendranath, 1986 .

The Conversion of Phenols to the Corresponding Aryl Halides Under Mild Conditions

G. Kabalka, M. Akula, J. Huffman, 2005 .

Cannabimimetic indoles, pyrroles and indenes.

J. Huffman, John W. Huffman, 1999, Current medicinal chemistry.

A one step synthesis of Flindersine

J. Huffman, T. Hsu, 1972 .

Design, synthesis and pharmacology of cannabimimetic indoles

John W. Huffman, D. R. Compton, B. Martin, 1994 .

Cannabimimetic lndoles, Pyrroles and lndenes

J. Huffman, 1999, Current Medicinal Chemistry.

Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors.

A. Howlett, N. Stella, D. Hurst, 2023, European journal of medicinal chemistry.

Acylation of N-p-Toluenesulfonylpyrrole Under Friedel-Crafts Conditions. Evidence for Organoaluminum Intermediates.

V. Smith, L. Padgett, J. Huffman, 2008, Tetrahedron.

Stereochemistry of the Cycloheptane Ring. Synthesis and Deamination of cis and trans-2-Aminocycloheptanol

J. Huffman, J. Engle, 1959 .

The synthesis and reactions of some isoquinuclidones.

J. Huffman, T. Kamiya, C. Rao, 1967, The Journal of organic chemistry.

Reactions of enaminones with 1-nitroolefins. Scope and limitations of a polyquinane synthesis

M. Cooper, J. Huffman, W. Pennington, 1992 .

J. Huffman, 1962 .

Solvent and stoichiometric effects in the reactions of cyclohexanone-pyrrolidine enamines with electrophilic olefins

J. Huffman, Fred J. Matthews, C. D. Rowe, 1982 .

A New Synthetic Route to Methoxytetralones

J. Huffman, 1959 .

Synthesis of (.+-.)-isocelorbicol

J. Huffman, R. Desai, G. F. Hillenbrand, 1984 .

A Procedure for Alcohol Inversion Using Cesium Acetate

J. Huffman, R. Desai, 1983 .

Dimeric products and hydrogen transfer in the dissolving metal reduction of camphor

J. Huffman, R. Wallace, 1989 .

Enolization of 2-decalones

J. Huffman, W. Balke, 1988 .

The Cyclization of Some β-Ferrocenylpropionic Acids

J. Huffman, R. L. Asbury, 1965 .

Potassium Triphenylmethide A Strong Base for Organic Synthesis

J. Huffman, P. Harris, 1977 .

Some Reactions of Chloroferrocene with Organolithium Compounds1

L. H. Keith, J. Huffman, R. L. Asbury, 1965 .

Notes- The Preparation of 1,2-(α-Ketotetramethylene)ferrocene

J. Huffman, D. Rabb, 1961 .

Synthesis of n-Alkylnaphthalenes via Semicarbazones

Gulay Zengin, J. Huffman, 2006 .

Studies on Resin Acids. II.1 Synthesis of Some Tricyclic Steroid Analogs

J. Huffman, P. G. Arapakos, 1965 .

Studies on Resin Acids. 1-Ketonordehydroabietane

R. F. Stockel, J. Huffman, 1963 .

Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor.

John W Huffman, Karla-Sue C Marriott, J. Huffman, 2008, Current topics in medicinal chemistry.

Mesonephric remnants in the cervix.

J. Huffman, 1948, American journal of obstetrics and gynecology.

Clinical significance of the paraurethral ducts and glands.

J. Huffman, 1951, A.M.A. archives of surgery.

The detailed anatomy of the paraurethral ducts in the adult human female

J. Huffman, 1948 .

Synthesis of (+-)-hexahydropronuciferine and related compounds

J. Huffman, C. E. Opliger, 1971 .

Synthesis of proaporphine alkaloids. (±)-Hexahydropronuciferine

J. Huffman, C. E. Opliger, 1969 .

Resin acids. VI. Synthesis of (+)-4-epidehydroabietic acid

J. Huffman, 1970 .

Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids.

J. Wiley, J. Huffman, J. Marusich, 2014, Life sciences.

JWH018, a common constituent of ‘Spice’ herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist

K. Mackie, Brady K. Atwood, J. Huffman, 2010, British journal of pharmacology.

Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice.

J. Warner, B. Martin, J. Wiley, 2009, European journal of pharmacology.

Cannabinoids control spasticity and tremor in a multiple sclerosis model

R. Pertwee, G. Pryce, D. Baker, 2000, Nature.

The Infertile Period: Principles and Practice.

J. Huffman, 1963 .

Vulvar disorders in premenarchal children.

J. Huffman, 1960, Clinical obstetrics and gynecology.

An evaluation of androgenic therapy in gynecologic practice

J. Huffman, 1940 .

Dyspareunia of vulvo-vaginal origin. Causes and management.

J. Huffman, 1983, Postgraduate medicine.

Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A.

J. Lowe, S. Welch, J. Huffman, 1998, The Journal of pharmacology and experimental therapeutics.

Synthesis of 5′,11-dihydroxy-Δ8-tetrahydrocannabinol

Ming-Jung Wu, J. Huffman, D. Dai, 1997 .

Synthesis of (.+‐.)‐11‐Nor‐9‐carboxy‐δ9‐tetrahydrocannabinol: New Synthetic Approaches to Cannabinoids.

Ming-Jung Wu, J. Huffman, W. Pennington, 2010 .

3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor.

S. Yu, J. Liddle, B. Martin, 1999, Bioorganic & medicinal chemistry.

Synthesis of a tetracyclic, conformationally constrained analogue of Δ8-THC

J. Huffman, Shu Yu, 1998 .

Stereoselective synthesis of the epimeric Δ7-tetrahydrocannabinols

D. R. Compton, B. Martin, P. Reggio, 1995 .

Roentgenographic and Other Techniques in the Diagnosis of Uterotubal Factors in Sterility and Infertility

J. Huffman, 1969 .

Resin acids. V. Preparation and reactions of ring-A olefins from dehydroabietic acid

J. Huffman, 1970 .

CB2 cannabinoid receptor agonists attenuate TNF‐α‐induced human vascular smooth muscle cell proliferation and migration

K. Mackie, P. Pacher, P. Mukhopadhyay, 2008, British journal of pharmacology.

EFFECT OF TESTOSTERONE PROPIONATE UPON REPRODUCTION IN THE FEMALE

J. Huffman, 1941 .

Gonorrhea: unmasking asymptomatic or atypical infection.

J. Huffman, 1978, Postgraduate medicine.

Use of SPME-HS-GC-MS for the analysis of herbal products containing synthetic cannabinoids.

B. Thomas, J. Wiley, Megan Grabenauer, 2012, Journal of analytical toxicology.

Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands

A. Poso, A Poso, J W Huffman, 2008, British journal of pharmacology.

1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice.

B. Martin, J. Wiley, J. Huffman, 2012, Drug and alcohol dependence.

Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.

Cristina Blázquez, J. Jorcano, M. Guzmán, 2003, The Journal of clinical investigation.

The stereochemistry of reduction by complex metal hydrides

J. Huffman, D. Wheeler, 1960, Experientia.

Friedel-Crafts reaction of 3,4,4-trimethylbutyrolactone and benzene

J. Huffman, J. Starnes, 1972 .

Enantioselective synthesis of 11-hydroxy-(1′S,2′R)-dimethylheptyl-Δ8-THC, a very potent CB1 agonist

J. Liddle, J. Huffman, 2001 .

Recent developments in the medicinal chemistry of cannabinoids

J. Huffman, J. A. Lainton, 1996 .

Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist.

C. Breivogel, M. Cascio, D. Bolognini, 2011, European journal of pharmacology.

Evaluation of first generation synthetic cannabinoids on binding at non-cannabinoid receptors and in a battery of in vivo assays in mice

B. Thomas, J. Wiley, K. Moore, 2016, Neuropharmacology.

Abdominal complete hysterectomy.

W. W. Curtis, J. Huffman, E. Suckow, 1950, American Journal of Obstetrics and Gynecology.

Psychosomatic obstetrics, gynecology and endocrinology, including diseases of metabolism.

J. Huffman, 1963 .

Trichomonas vaginalis vaginitis: Treatment with iodochlorhydroxyquinoline

J. Huffman, 1935 .

Adeno carcinoma of the female urethra; a review.

J. Huffman, L. Walker, 1947, Quarterly bulletin. Northwestern University (Evanston, Ill.). Medical School.

The detailed anatomy of the para-urethral ducts in the adult human female.

J. Huffman, 1948, American journal of obstetrics and gynecology.

Disorders of the external genitals and vagina.

J. Huffman, 1958, Pediatric clinics of North America.

Gynecology of children and adolescents; report of a round table discussion.

J. Huffman, E. Wieczorowski, 1958, Pediatrics.

The synthesis of desenthylibogamine.

J. Huffman, T. Kamiya, C. Rao, 1967, The Journal of organic chemistry.

New Synthetic Approach to the Berberine Alkaloids

E. Miller, J. Huffman, 1960 .

REDUCTION OF 12-KETO STEROIDS. 2

J. Huffman, D. Copley, 1977 .

Synthetie approaches to steroidal alkaloids III . An attempted synthesis of ring-e of veratramine†

J. Huffman, S. N. Singh, 1973 .

Endometriosis in young teen-age girls.

J. Huffman, 1981, Pediatric annals.

Regioselective synthesis of (.+-.)-11-Nor-9-carboxy-.DELTA.9-THC

Ming-Jung Wu, Xuehai Zhang, J. Huffman, 1989 .

Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.

D. R. Compton, B. Martin, J. Wiley, 1996, Journal of medicinal chemistry.

Counseling the menopausal patient.

J. Huffman, 1979, Postgraduate medicine.

CB2 receptor ligands.

J. Huffman, 2005, Mini reviews in medicinal chemistry.

2-Bromo-N-(p-toluenesulfonyl)pyrrole

J. Huffman, W. Pennington, Clifford W. Padgett, 2003 .

CB2 receptor agonists attenuate TNF‐α induced human vascular smooth muscle cell proliferation and migration

K. Mackie, P. Pacher, S. Batkai, 2008 .

DRUG ABUSE IN PREGNANCY AND NEONATAL EFFECTS

J. Huffman, 1979 .

Dissolving metal reduction of cyclic ketones

J. Huffman, W. Mcwhorter, 1979 .

Stereochemistry of the Tetrahydroabietic Acids1

L. H. Wright, W. Herz, J. Huffman, 1966 .

THE STRUCTURE AND BACTERIOLOGY OF THE PREMENARCHAL VAGINA

J. Huffman, 1959, Annals of the New York Academy of Sciences.

Gynecologic examination of the premenarchal child.

J. Huffman, 1959, Postgraduate medicine.

SYNTHESIS OF AGAROFURANS BY CYCLIZATION OF 10‐EPIEUDESMENE‐3,11‐DIOLS

J. Huffman, R. Desai, 1983 .

Synthesis of both enantiomers of nabilone from a common intermediate. Enantiodivergent synthesis of cannabinoids

J. Huffman, W. Pennington, R. D. Jordan, 1991 .

THE HEMODYNAMIC ACTION OF MINIMAL EFFECTIVE DOSES OF EPINEPHRIN IN THE UNANESTHETIZED DOG

J. Huffman, C. Dragstedt, Ardath H. Wightman, 1928 .

Synthesis of (.+-.)-cacalol

J. Huffman, R. Pandian, 1979 .

Synthetic approaches to steroidal alkaloids II (1). Preparation and reactions of 12-oxo-dinorcholanic acids.

J. Huffman, R. R. Sobti, 1970, Steroids.

THE COMPARATIVE EFFECT OF EPINEPHRIN UPON BLOOD PRESSURE AND INTESTINAL MOTILITY IN THE DOG

J. Huffman, C. Dragstedt, 1928 .