J. Koh

发表

The farnesyltransferase inhibitor, LB42708, inhibits growth and induces apoptosis irreversibly in H-ras and K-ras-transformed rat intestinal epithelial cells.

S. S. Koh, S. Song, Hyun-Ho Chung, 2006, Toxicology and applied pharmacology.

Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase.

Hyun-Ho Chung, Jinho Lee, J. Koh, 2006, Bioorganic & medicinal chemistry letters.

A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase).

Y. Shin, J. Kim, H. Lee, 2001, Bioorganic & medicinal chemistry letters.

3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors.

Y. Shin, J. Kim, H. Lee, 2001, Bioorganic & medicinal chemistry letters.

Inhibition of Farnesyltransferase Prevents Collagen-Induced Arthritis by Down-Regulation of Inflammatory Gene Expression through Suppression of p21ras-Dependent NF-κB Activation1

K. Ha, Seon-Jin Lee, Young-Guen Kwon, 2004, The Journal of Immunology.

G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia.

Ho-Juhn Song, J. Cools, H. Kim, 2014, Blood.

β-Methanesulfonyl-L-valine as a novel, unnatural amino acid surrogate for P2 in the design of HIV protease inhibitors.

Y. Kwon, Ho-il Choi, J. Koh, 1996 .

Design and Synthesis of Oxime Ethers of β-Oxo-γ-phenylbutanoic Acids as PPAR α and -γ Dual Agonists

Hee Oon Han, H. Yim, J. Koh, 2012 .

Design of a Nonnatural Deoxyribonucleoside for Recognition of GC Base Pairs by Oligonucleotide‐Directed Triple Helix Formation.

P. Dervan, J. Koh, 1992 .

B Activation k -Dependent NF-ras Expression through Suppression of p21 Down-Regulation of Inflammatory Gene Collagen-Induced Arthritis by Inhibition of Farnesyltransferase Prevents

K. Ha, Seon-Jin Lee, Young-Guen Kwon, 2004 .

MYELOID NEOPLASIA G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia

Ho-Juhn Song, J. Cools, H. Kim, 2014 .

Antitumor Activity of LB42907, a Potent and Selective Farnesyltransferase Inhibitor: Synergistic Effect in Combination with Other Anticancer Drugs

Shinwu Jeong, Semi Kim, J. H. Park, 2008 .

Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones.

Hee Oon Han, S. Hong, K. D. Koo, 2007, Bioorganic & medicinal chemistry letters.

NMR and topochemical studies of peptidomimetic HIV-I protease inhibitors containing a cis-epoxide amide isostere.

J. Ok, B. Lee, C. Lee, 1998, Bioorganic & medicinal chemistry letters.

Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors.

N. Kang, H. Jung, Sun-Young Han, 2010, Bioorganic & medicinal chemistry letters.

Solid phase synthesis of hydantoin library using a novel cyclization and traceless cleavage step

Jinho Lee, S. Ro, Sang Wong Kim, 1997 .

Synthesis of irreversible HIV-1 protease inhibitors containing sulfonamide and sulfone as amide bond isosteres

Ho-il Choi, J. Koh, W. Jung, 1997 .

Solid phase synthesis of benzylamine-derived sulfonamide library.

K. Lee, J. Koh, C. Hong, 1998, Bioorganic & medicinal chemistry letters.

Synthesis of Irreversible HIV-1 Protease Inhibitors Containing Sulfonamide and Sulfone as Amide Bond Isosteres.

Ho-il Choi, J. Koh, W. Jung, 1998 .

Rational design of irreversible, pseudo-C2-symmetric hiv-1 protease inhibitors

Ho-il Choi, K. Moon, J. Koh, 1995 .

Solid phase synthesis of benzamidine-derived sulfonamide libraries

Sang Wong Kim, J. Koh, C. Hong, 1997, Molecular Diversity.

Solid phase synthesis of benzamidine and butylamine-derived hydantoin libraries

S. Ro, Sang Wong Kim, J. Koh, 1997, Molecular Diversity.

Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors.

Chi-Hoon Park, H. Jung, Sang-Un Choi, 2012, Bioorganic & medicinal chemistry letters.

RESEARCH NOTE: PHOTOREACTION OF 4′, 5′‐DIHYDROPSORALEN WITH THYMINE

J. Koh, S. Shim, H. K. Shim, 1983, Photochemistry and photobiology.

Palladium-Mediated Three-Component Coupling Strategy for the Solid-Phase Synthesis of Tropane Derivatives(1).

J. Ellman, J. Koh, 1996, The Journal of organic chemistry.

Design of a nonnatural deoxyribonucleoside for recognition of GC base pairs by oligonucleotide-directed triple helix formation

P. Dervan, J. Koh, 1992 .

YH25448, an Irreversible EGFR-TKI with Potent Intracranial Activity in EGFR Mutant Non–Small Cell Lung Cancer

Ho-Juhn Song, Soyoung Kim, B. Cho, 2019, Clinical Cancer Research.

Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer.

Jae Cheol Lee, Ho-Juhn Song, J. K. Kim, 2017, Cancer research.

Confirmation of a linkage between H‐Ras and MMP‐13 expression as well as MMP‐9 by chemical genomic approach

Cheol‐Hee Kim, D. Han, K. Son, 2006, International journal of cancer.

Prognostic significance of c‐Met expression in glioblastomas

Do-Hyun Nam, Yeon-Lim Suh, Jung-Il Lee, 2009, Cancer.

Serologic responses of Korean soldiers serving in malaria-endemic areas during a recent outbreak of Plasmodium vivax.

D. Strickman, D. Kaslow, G. Hur, 2000, The American journal of tropical medicine and hygiene.

Evaluation of a multi-kinase inhibitor KRC-108 as an anti-tumor agent in vitro and in vivo

H. Jung, Mi-Ok Lee, H. Cha, 2012, Investigational New Drugs.

Title: Superior efficacy and selectivity of novel small molecule kinase inhibitors of T790M mutant EGFR in preclinical models of lung cancer Running title: EGFR TKIs with improved mutant selectivity and CNS potency

Jae Cheol Lee, Ho-Juhn Song, J. K. Kim, 2016 .

Enhancement of interleukin-12 gene-based tumor immunotherapy by the reduced secretion of p40 subunit and the combination with farnesyltransferase inhibitor.

S. Ha, Y. Sung, Je-in Youn, 2005, Human gene therapy.

Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors.

N. Kang, H. Jung, Sang-Un Choi, 2011, Bioorganic & medicinal chemistry letters.

Engineering metal coordination sites into the antibody light chain

R. Lerner, D. Hoekstra, W. Wade, 1993 .

Correction: Crystal Structure of Pim1 Kinase in Complex with a Pyrido[4,3-D]Pyrimidine Derivative Suggests a Unique Binding Mode

Ho-Juhn Song, B. Han, Jea-Won Cho, 2018, PloS one.

Crystal Structure of Pim1 Kinase in Complex with a Pyrido[4,3-D]Pyrimidine Derivative Suggests a Unique Binding Mode

Ho-Juhn Song, B. Han, Jea-Won Cho, 2013, PloS one.

Phosphatase of regenerating liver‐3 promotes migration and invasion by upregulating matrix metalloproteinases‐7 in human colorectal cancer cells

Su-Hyung Hong, D. Han, C. Lee, 2012, International journal of cancer.

Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors

Ho-Juhn Song, B. Lee, Sang Jae Lee, 2018, Molecules and cells.

Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs

Ho-Juhn Song, S. Goh, B. Han, 2016, The FEBS journal.

Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities.

Sun Hwa Lee, J. Koh, H. Kim, 2012, Bioorganic & medicinal chemistry letters.

Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors.

Ho-Juhn Song, B. Lee, J. Koh, 2015, Bioorganic & medicinal chemistry letters.

B Activation k -Dependent NF-ras Expression through Suppression of p21 Down-Regulation of Inflammatory Gene Collagen-Induced Arthritis by Inhibition of Farnesyltransferase Prevents

K. Ha, Seon-Jin Lee, Young-Guen Kwon, 2004 .