E. Freyne

发表

5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.

G. Mannens, P. Muller, P. van Remoortere, 2003, Bioorganic & medicinal chemistry letters.

Design and Synthesis of a Series of Piperazine‐1‐carboxamidine Derivatives with Antifungal Activity Resulting from Accumulation of Endogenous Reactive Oxygen Species

J. Heeres, L. Meerpoel, J. Pastor, 2009, ChemMedChem.

Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.

M. Janicot, C. Meyer, G. Mannens, 2003, Bioorganic & medicinal chemistry letters.

Inhibition of human cardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds.

P. Janssen, E. Freyne, D. de Cheffoy de Courcelles, 1992, The Journal of pharmacology and experimental therapeutics.

Identification of R146225 as a novel, orally active inhibitor of interleukin-5 biosynthesis.

F. Aerts, F. Deroose, J. Lacrampe, 2000, The Journal of pharmacology and experimental therapeutics.

R 68 070: Thromboxane A2 Synthetase Inhibition and Thromboxane A2/Prostaglandin Endoperoxide Receptor Blockade Combined in One Molecule - I. Biochemical Profile In Vitro

P. Janssen, F. De Clerck, F. Clerck, 1989, Thrombosis and Haemostasis.

Comparative effects of the aromatase inhibitor R76713 and of its enantiomers R83839 and R83842 on steroid biosynthesis in vitro and in vivo

A. Raeymaekers, J. V. Gelder, M. Janssen, 1990, The Journal of Steroid Biochemistry and Molecular Biology.

Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.

M. Janicot, L. van Hijfte, H. De Winter, 2005, European journal of medicinal chemistry.

Chemical ionization desorption mass spectrometry as an additional tool for the structure elucidation of nucleosides

E. Esmans, F. Alderweireldt, E. Freyne, 1980 .

Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.

F. Sommen, A. Sharff, V. Berdini, 2015, ACS medicinal chemistry letters.

Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.

M. Janicot, M. Noppe, L. van Hijfte, 2010, Bioorganic & medicinal chemistry letters.

4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.

A. Saha, C. Meyer, G. Mannens, 2003, Bioorganic & medicinal chemistry letters.

Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology.

A. Raeymaekers, E. Freyne, M. Venet, 1998, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 1,2,4-triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma.

L. Dillen, F. Deroose, J. Lacrampe, 2005, Journal of medicinal chemistry.

Stereospecific synthesis of a novel series of pyridine nucleosides

E. Esmans, J. Lepoivre, F. Alderweireldt, 1980 .

The synthesis of 5-carboxamido-4-hydroxy-3-(β-D-ribofuranosyl)-thiophene derivatives, analogues of pyrazofurin

E. Freyne, G. Hoornaert, D. K. Buffel, 1984 .

R 75251, a new inhibitor of steroid biosynthesis

P. Janssen, E. Snoeck, A. Raeymaekers, 1990, The Prostate.

R 76713, a new specific non-steroidal aromatase inhibitor.

A. Raeymaekers, E. Freyne, J. van Dun, 1989, Journal of steroid biochemistry.

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

C. Murray, J. Vialard, D. Newell, 2017, Molecular Cancer Therapeutics.

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.

V. Berdini, D. Brehmer, J. Linders, 2015, ACS medicinal chemistry letters.

Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models

C. Murray, V. Berdini, D. Newell, 2011, Molecular Cancer Therapeutics.

Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.

A. Megens, J. M. Alonso, D. Peeters, 2002, Bioorganic & medicinal chemistry letters.

Analogues de 3-phenyle de toxoflavine en tant qu'inhibiteurs de kinase

P. Buijnsters, C. Ho, J. Lacrampe, 2003 .

Synthesis of a novel β-NAD+ analogue: 3-Ac-5-Me-PyrAD+.

E. Esmans, J. Lepoivre, F. Alderweireldt, 2010 .

JNJ-26854165 - a novel hdm2 antagonist in clinical development showing broad-spectrum preclinical antitumor activity against solid malignancies

C. Blattner, M. Janicot, P. Verhasselt, 2008 .

Short Communication Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors

M. Janicot, Laurence Quéguiner, L. Hijfte, 2005 .

Abstract 1738: JNJ-42756493 is an inhibitor of FGFR-1, 2, 3and4 with nanomolar affinity for targeted therapy

C. Murray, J. Vialard, D. Newell, 2014 .

588 POSTER JNJ-26483327 is a novel multi-targeted tyrosine kinase inhibitor with cellular activity against EGFR, Her2, Src and VEGFR3

M. Janicot, M. Versele, M. Page, 2006 .