P. Pachl

发表

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.

J. Konvalinka, J. Pokorná, M. Kožíšek, 2018 .

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus

J. Konvalinka, J. Pokorná, M. Kožíšek, 2018, Viruses.

A novel structurally characterized haloacid dehalogenase superfamily phosphatase from Thermococcus thioreducens with diverse substrate specificity.

M. Pusey, J. Brynda, J. Mesters, 2019, Acta crystallographica. Section D, Structural biology.

Structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor.

J. Konvalinka, J. Hodek, M. Kožíšek, 2020, Antiviral research.

Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.

J. Konvalinka, P. Majer, P. Šácha, 2014, Bioorganic & medicinal chemistry.

Crystal structure of native β‐N‐acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide

Z. Otwinowski, J. Brynda, P. Man, 2018, The FEBS journal.

Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5.

J. Damborský, R. Chaloupkova, J. Brynda, 2019, Acta crystallographica. Section F, Structural biology communications.

Crystal structure of native α-L-rhamnosidase from Aspergillus terreus.

Z. Otwinowski, P. Mader, V. Křen, 2018, Acta crystallographica. Section D, Structural biology.

Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis

W. Patrick, M. Selmer, C. Squire, 2021, The Journal of biological chemistry.

Conformationally constrained nucleoside phosphonic acids--potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases.

J. Brynda, V. Veverka, P. Řezáčová, 2014, Organic & biomolecular chemistry.

Biophysical characterization of recombinant human ameloblastin.

J. Vondrášek, R. Osicka, M. Sulc, 2011, European journal of oral sciences.

In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals.

J. Brynda, Z. Voburka, E. Petri, 2018, Acta crystallographica. Section F, Structural biology communications.

Backbone resonance assignments of human cytosolic dNT-1 nucleotidase

Zdeněk Tošner, J. Brynda, V. Veverka, 2014, Biomolecular NMR assignments.

Backbone resonance assignments of human cytosolic dNT-1 nucleotidase

Zdeněk Tošner, J. Brynda, V. Veverka, 2013, Biomolecular NMR Assignments.

DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors.

J. Konvalinka, I. Císařová, M. Kožíšek, 2018 .

DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors

J. Konvalinka, I. Císařová, M. Kožíšek, 2018, The Biochemical journal.

Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.

J. Konvalinka, M. Kožíšek, P. Řezáčová, 2019, Bioorganic & medicinal chemistry.

Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza.

J. Konvalinka, M. Kožíšek, P. Řezáčová, 2016, European journal of medicinal chemistry.

Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure.

V. Kryštof, P. Řezáčová, J. Jansa, 2021, European journal of medicinal chemistry.

3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.

M. Strnad, L. Havlícek, V. Kryštof, 2019, Journal of medicinal chemistry.

Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides.

C. Supuran, P. Mader, J. Brynda, 2011, Journal of medicinal chemistry.

An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily

P. Řezáčová, Pavla Bartošová-Sojková, M. Horn, 2023, The Journal of biological chemistry.

The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir

I. Pichová, J. Brynda, P. Řezáčová, 2012, Journal of enzyme inhibition and medicinal chemistry.

Structural insights into tick-borne encephalitis virus neutralization and animal protection by a therapeutic antibody

G. Chojnowski, V. Lamzin, P. Řezáčová, 2021, bioRxiv.

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia

V. Veverka, P. Man, P. Řezáčová, 2016, BMC Biology.

Metallacarborane sulfamides: unconventional, specific, and highly selective inhibitors of carbonic anhydrase IX.

V. Král, J. Brynda, P. Džubák, 2019, Journal of medicinal chemistry.

Rutinosidase from Aspergillus niger: Crystal structure and insight into the enzymatic activity.

V. Křen, J. Brynda, L. Biedermannová, 2020, The FEBS journal.

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

J. Konvalinka, H. Kräusslich, B. Müller, 2015, Nature Communications.

General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases

David C. Mikles, K. Vinothkumar, M. Lepšík, 2017, Cell chemical biology.

Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity

M. Gütschow, C. Caffrey, P. Řezáčová, 2020, ACS infectious diseases.

Kinetic and structural characterization of an alternatively spliced variant of human mitochondrial 5′(3′)-deoxyribonucleotidase

J. Brynda, V. Veverka, P. Řezáčová, 2015, Journal of Enzyme Inhibition and Medicinal Chemistry.

Structure-Based Optimization of Bisphosphonate Nucleoside Inhibitors of Human 5′(3′)-deoxyribonucleotidases

J. Brynda, P. Řezáčová, M. Buděšínský, 2018, European Journal of Organic Chemistry.

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.

V. Veverka, J. Trka, D. Ascher, 2018 .

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation

David B. Ascher, Petr Novák, William L. Carroll, 2018, Leukemia.

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors

I. Pichová, J. Brynda, P. Řezáčová, 2023, Journal of medicinal chemistry.

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome

J. Mackay, R. Payne, H. Suga, 2023, bioRxiv.

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia

V. Veverka, P. Man, P. Řezáčová, 2016, BMC Biology.

Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities

J. Konvalinka, L. Rulíšek, K. Hlouchová, 2016, The FEBS journal.

Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors.

J. Brynda, P. Řezáčová, I. Rosenberg, 2014, Acta crystallographica. Section D, Biological crystallography.

Structure-based design of a bisphosphonate 5′(3′)-deoxyribonucleotidase inhibitor

J. Brynda, P. Řezáčová, M. Buděšínský, 2015 .

Structure of the mouse galectin-4 N-terminal carbohydrate-recognition domain reveals the mechanism of oligosaccharide recognition.

J. Brynda, P. Malý, P. Řezáčová, 2011, Acta crystallographica. Section D, Biological crystallography.

Crystallization and diffraction analysis of β-N-acetylhexosaminidase from Aspergillus oryzae.

Ondřej Vaněk, Zdeněk Kukačka, J. Brynda, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus

J. Konvalinka, M. Kožíšek, P. Řezáčová, 2018, Viruses.

Complex of H275Y/I223V mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir

J. Konvalinka, M. Kožíšek, P. Řezáčová, 2018 .