A. Manelli

发表

A robust and high-capacity [(35)S]GTPgammaS binding assay for determining antagonist and inverse agonist pharmacological parameters of histamine H(3) receptor ligands.

J. Brioni, T. Esbenshade, M. Cowart, 2008, Assay and drug development technologies.

Isoform-specific binding of apolipoprotein E to beta-amyloid.

G. Getz, M. Falduto, M. LaDu, 1994, The Journal of biological chemistry.

Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.

Jill M. Wetter, G. Diaz, J. Brioni, 2012, European journal of pharmacology.

Inhibition of age-induced beta-amyloid neurotoxicity in rat hippocampal cells.

P. Puttfarcken, J. Neilly, D. Frail, 1996, Experimental Neurology.

Inhibition of Age-Induced β-Amyloid Neurotoxicity in Rat Hippocampal Cells

P. Puttfarcken, J. Neilly, D. Frail, 1996, Experimental Neurology.

Apolipoprotein E modulates γ‐secretase cleavage of the amyloid precursor protein

B. Hyman, A. Lleó, M. Irizarry, 2004, Journal of neurochemistry.

In vitro studies on a class of quinoline containing histamine H3 antagonists.

G. Diaz, J. Brioni, Ruth L. Martin, 2010, Bioorganic & medicinal chemistry letters.

Cloning and characterization of the monkey histamine H3 receptor isoforms.

J. Brioni, G. Fox, T. Vortherms, 2008, European journal of pharmacology.

Discovery and SAR of 4-Aminopyrrolidine-2-carboxylic Acid Correctors of CFTR for the Treatment of Cystic Fibrosis.

A. Bogdan, A. Swensen, Ashvani K. Singh, 2022, Bioorganic & medicinal chemistry letters.

Evidence Against a Role for the Kunitz Domain in Amyloidogenic and Secretory Processing of the Amyloid Precursor Protein

T. Holzman, W. Klein, Gary T. Wang, 1994, Journal of neurochemistry.

Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation.

M. LaDu, P. Sullivan, A. Manelli, 2007, Neurobiology of aging.

The Presence of the Complement Cascade Does Not Lead to Neuronal Cell Death in Primary Hippocampal Cultures

E. Cadman, P. Puttfarcken, K. Shiosaki, 1997, Brain Research Bulletin.

Aβ42 neurotoxicity in primary co-cultures: Effect of apoE isoform and Aβ conformation

M. LaDu, P. Sullivan, A. Manelli, 2007, Neurobiology of Aging.

ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-β1–42

G. Gamkrelidze, B. Trommer, M. LaDu, 2005, Neurobiology of Disease.

Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability*

L. K. Baker, G. Krafft, M. LaDu, 2002, The Journal of Biological Chemistry.

Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222

C. Tse, D. Cyr, A. Swensen, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Localization of histamine H4 receptors in the central nervous system of human and rat

J. Brioni, R. Bitner, G. Hsieh, 2009, Brain Research.

Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia.

M. LaDu, M. Ard, A. Manelli, 2005, Journal of Alzheimer's disease : JAD.

Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation

Jill A. White, L. J. Eldik, M. LaDu, 2005, Neurobiology of Disease.

ApoE and Aβ1–42 interactions

L. J. Eldik, M. LaDu, W. Stine, 2007, Journal of Molecular Neuroscience.

ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function.

L. V. Van Eldik, M. LaDu, W. Stine, 2004, Journal of molecular neuroscience : MN.

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.

A. Bogdan, C. Tse, A. Swensen, 2019, ACS medicinal chemistry letters.

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Sean M. Riordan, G. Bu, Chunjiang Yu, 2012, Molecular Neurodegeneration.

Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.

Jill M. Wetter, J. Brioni, P. Honore, 2010, Journal of medicinal chemistry.

Evidence for Nicotinic Receptors Potentially Modulating Nociceptive Transmission at the Level of the Primary Sensory Neuron: Studies with F11 Cells

D. Donnelly-roberts, S. Arneric, P. Puttfarcken, 1997, Journal of neurochemistry.

cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Jill M. Wetter, J. Brioni, P. Chandran, 2008, Journal of medicinal chemistry.

β-Amyloid-induced toxicity in rat hippocampal cells: In vitro evidence for the involvement of free radicals

P. Puttfarcken, A. Manelli, 1995, Brain Research Bulletin.

Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring.

J. Brioni, T. Esbenshade, M. Cowart, 2010, Bioorganic & medicinal chemistry letters.

Effect of Apolipoprotein E on Neurite Outgrowth and β‐Amyloid‐Induced Toxicity in Developing Rat Primary Hippocampal Cultures

G. Getz, M. Falduto, M. LaDu, 1997, Journal of neurochemistry.

Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.

Jill M. Wetter, G. Diaz, J. Brioni, 2012, European journal of pharmacology.

Cloning and characterization of a truncated dopamine D1 receptor from goldfish retina: stimulation of cyclic AMP production and calcium mobilization.

R. Mackenzie, D. Frail, D. Witte, 1993, Molecular pharmacology.