Julia Morizzi

发表

Gallium(III) organophosphonate adducts with the bidentate amines 2,2′-bipyridyl and 1,10-phenanthroline

C. Rix, Julia Morizzi, M. Hobday, 2001 .

An in vitro toolbox to accelerate anti-malarial drug discovery and development

David M. Shackleford, Dennis A. Smith, S. Charman, 2020, Malaria Journal.

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

P. Rathod, John White, M. Phillips, 2016, Journal of medicinal chemistry.

Two Analogues of Fenarimol Show Curative Activity in an Experimental Model of Chagas Disease

David M. Shackleford, M. J. Abbott, Paul W. Alexander, 2013, Journal of medicinal chemistry.

Discovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for Malaria.

J. Ge, S. Charman, R. Brun, 2010, ACS medicinal chemistry letters.

A prodrug approach toward cancer-related carbonic anhydrase inhibition.

C. Supuran, D. Vullo, S. Charman, 2013, Journal of medicinal chemistry.

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties.

David M. Shackleford, S. Charman, Marie Lopez, 2013, Bioorganic & medicinal chemistry letters.

Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography.

David M. Shackleford, S. Charman, David M Shackleford, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model*

James L. Hickey, C. Masters, P. Crouch, 2011, The Journal of Biological Chemistry.

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

David M. Shackleford, J. Chollet, S. Charman, 2017, Journal of medicinal chemistry.

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

David M. Shackleford, S. Charman, R. Brun, 2013, Drug design, development and therapy.

3',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy.

David M. Shackleford, Spencer J. Williams, H. Krum, 2013, Bioorganic & medicinal chemistry letters.

Some bidentate amine adducts of indium(III)organophosphonates

C. Rix, Julia Morizzi, M. Hobday, 2001 .

Synthesis and characterisation of a series of lamellar gallium and indium phosphonates and related compounds

C. Rix, Julia Morizzi, M. Hobday, 2000 .

Synthesis and characterisation of some lamellar indium phosphonates

C. Rix, Julia Morizzi, M. Hobday, 1999 .

Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.

M. J. Abbott, Paul W. Alexander, E. Chatelain, 2012, Journal of medicinal chemistry.

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

J. Chollet, S. Charman, W. Charman, 2010, Journal of medicinal chemistry.

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.

David M. Shackleford, K. Chibale, M. Witty, 2012, Journal of medicinal chemistry.

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.

J. Chollet, S. Charman, E. Ryan, 2013, Journal of medicinal chemistry.

Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials

Ian H. Gilbert, Marcel Kaiser, David M. Shackleford, 2013, Journal of medicinal chemistry.

Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-β-cyclodextrin or a co-solvent system.

David M. Shackleford, Susan A Charman, S. Charman, 2010, Biopharmaceutics & drug disposition.

Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE(7)-beta-CD on the disposition of chlorpromazine in the rat.

David M. Shackleford, R. Prankerd, M. Mcintosh, 2010, Journal of pharmaceutical sciences.

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

David M. Shackleford, D. Chalmers, D. Grobelny, 2011, Journal of medicinal chemistry.

S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.

C. Supuran, A. Innocenti, D. Vullo, 2009, Journal of medicinal chemistry.

Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII.

C. Supuran, D. Vullo, S. Charman, 2012, Journal of medicinal chemistry.

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Christian Scheurer, Lukas Stingelin, David M. Shackleford, 2011, Proceedings of the National Academy of Sciences.

Probing a potential in vivo drug-excipient interaction: temporal effects of a modified β-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand.

David M. Shackleford, S. Charman, Anne Mannila, 2012, Journal of Pharmacy and Science.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

David M. Shackleford, G. Drewes, M. Bantscheff, 2017, Science Translational Medicine.

The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine.

P. Couraud, I. Romero, B. Weksler, 2012, Molecular pharmaceutics.

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.

A. Ruf, S. Charman, W. Charman, 2008, Bioorganic & medicinal chemistry letters.

The comparative antimalarial properties of weak base and neutral synthetic ozonides.

J. Chollet, S. Charman, W. Charman, 2010, Bioorganic & medicinal chemistry letters.

1 CUII ( ATSM ) PROTECTS AGAINST PEROXYNITRITE-INDUCED NITROSATIVE DAMAGE AND PROLONGS SURVIVAL IN AN AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL

C. Masters, J. Duce, Qiao-Xin Li, 2011 .

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

David M. Shackleford, D. Chalmers, D. Grobelny, 2011, Journal of medicinal chemistry.