Akio Kobayashi

发表

Arachidonic acid‐containing phosphatidylcholine characterized by consolidated plasma and liver lipidomics as an early onset marker for tamoxifen‐induced hepatic phospholipidosis

Kosuke Saito, Yoshiro Saito, Keisuke Goda, 2017, Journal of applied toxicology : JAT.

JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice.

T. Ohta, Y. Ishii, M. Kakutani, 2015, Journal of pharmacological sciences.

Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats.

K. Yoshinari, Yusuke Suzuki, Akio Kobayashi, 2020, The Journal of toxicological sciences.

Specificity of transaminase activities in the prediction of drug-induced hepatotoxicity.

Yusuke Suzuki, Akio Kobayashi, S. Sugai, 2020, The Journal of toxicological sciences.

Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-Leprfa (SDT fatty) rats.

Yusuke Suzuki, K. Shimoi, Akio Kobayashi, 2019, The Journal of toxicological sciences.

Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.

Masahiro Tanaka, Kexue Li, Masahiro Suzuki, 2014, Journal of medicinal chemistry.

Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients.

Yusuke Suzuki, Akio Kobayashi, Naohito Yamada, 2012, The Journal of toxicological sciences.

Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats.

Yusuke Suzuki, K. Shimoi, H. Sakakibara, 2009, The Journal of toxicological sciences.

A pharmacologic increase in activity of plasma transaminase derived from small intestine in animals receiving an acyl CoA: diacylglycerol transferase (DGAT) 1 inhibitor.

T. Masuyama, Akio Kobayashi, S. Sugai, 2018, The Journal of toxicological sciences.

Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats.

K. Shimoi, J. Kataoka, H. Sakakibara, 2011, The Journal of toxicological sciences.

Relationships between plasma and tissue transaminase activities in rats maintained under different feeding conditions.

K. Shimoi, H. Sakakibara, Akio Kobayashi, 2010, The Journal of toxicological sciences.

Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide‐induced hepatic steatosis in rats

Kosuke Saito, T. Masuyama, Akio Kobayashi, 2022, Journal of applied toxicology : JAT.

Urinary excretion of oxidative metabolites of bilirubin in fenofibrate-treated rats.

H. Iwatsuka, Tokio Yamaguchi, Akio Kobayashi, 2003, The Journal of toxicological sciences.

Ether-phosphatidylcholine characterized by consolidated plasma and liver lipidomics is a predictive biomarker for valproic acid-induced hepatic steatosis.

Kosuke Saito, Yoshiro Saito, Keisuke Goda, 2018, The Journal of toxicological sciences.

The Journal of Toxicological Sciences

K. Yoshinari, Yusuke Suzuki, Akio Kobayashi, 2014 .

Evaluation of the Potential Risk of Drugs to Induce Hepatotoxicity in Human—Relationships between Hepatic Steatosis Observed in Non-Clinical Toxicity Study and Hepatotoxicity in Humans-

Kosuke Saito, Yoshiro Saito, K. Maekawa, 2017, International journal of molecular sciences.

High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats.

Yusuke Suzuki, T. Masuyama, Akio Kobayashi, 2018, The Journal of toxicological sciences.

Social isolation stress induces hepatic hypertrophy in C57BL/6J mice.

N. Ohashi, T. Nakayama, K. Shimoi, 2012, The Journal of toxicological sciences.

Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury.

Keisuke Goda, Akio Kobayashi, S. Sugai, 2016, The Journal of toxicological sciences.

Active-phase Plasma Alkaline Phosphatase Isozyme Activity Is a Sensitive Biomarker for Excessive Fructose Intake

H. Sakakibara, Akio Kobayashi, Taishi Shimazaki, 2023, In Vivo.

Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model

H. Sakakibara, Akio Kobayashi, Kazuma Kondo, 2023, In Vivo.

Impact of microsampling on toxicological evaluation in rodent safety studies

Kosuke Saito, Akio Kobayashi, N. Hattori, 2023, Journal of applied toxicology : JAT.

Lack of toxicological influences by microsampling (50 µL) from jugular vein of rats in a collaborative 28-day study.

Kosuke Saito, Yoshiro Saito, Akio Kobayashi, 2020, The Journal of toxicological sciences.