M. N. Horton

N-demethylation accompanies alpha-hydroxylation in the metabolic activation of tamoxifen in rat liver cells.

D. Phillips, A. Hewer, P. Carmichael, 1999, Carcinogenesis.

The deuterium isotope effect for the alpha-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D5-ethyl]tamoxifen.

M. Rowlands, M. Jarman, R. Grimshaw, 1995, Carcinogenesis.

Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen.

S. Venitt, D. Phillips, A. Hewer, 1994, Carcinogenesis.

Synthesis of [D5-ethyl]-tamoxifen ; a mechanistic probe of tamoxifen induced hepatic DNA adduct formation

M. Jarman, G. A. Potter, M. N. Horton, 1994 .

Identification of tamoxifen metabolites in human Hep G2 cell line, human liver homogenate, and patients on long-term therapy for breast cancer.

P. Lønning, B. Walter, R. Mccague, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis and DNA reactivity of alpha-hydroxylated metabolites of nonsteroidal antiestrogens

D. Phillips, A. Hewer, I. Hardcastle, 1998 .

Synthesis and DNA reactivity of alpha-hydroxylated metabolites of nonsteroidal antiestrogens.

D. Phillips, A. Hewer, I. Hardcastle, 1998, Chemical research in toxicology.