Holly M. Micolochick Steuer

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The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

M. Otto, Haiying Bao, E. Murakami, 2007, Antimicrobial Agents and Chemotherapy.

Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein.

A. Lee, S. Majeski, A. Cuconati, 2021, Antiviral research.

Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

Quanxin Long, N. Snead, A. Lee, 2018, Antimicrobial Agents and Chemotherapy.

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

M. Otto, C. Espiritu, A. Lam, 2012, Antimicrobial Agents and Chemotherapy.

Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

M. Otto, L. Stuyver, R. Schinazi, 2007, Antimicrobial Agents and Chemotherapy.

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

M. Otto, C. Espiritu, A. Lam, 2011, Antimicrobial Agents and Chemotherapy.

Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

A. Lee, A. Lam, D. Gotchev, 2021, bioRxiv.

Therapeutic Potential of TLR8 Agonist GS‐9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators

S. Lehar, W. Rosenberg, S. Fletcher, 2020, Hepatology.

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.

M. Otto, C. Espiritu, A. Lam, 2011, Antiviral research.

The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

M. Otto, Haiying Bao, E. Murakami, 2008, Antimicrobial agents and chemotherapy.

Use of 2'-spirocyclic ethers in HCV nucleoside design.

C. Espiritu, A. Lam, M. Sofia, 2014, Journal of medicinal chemistry.

Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

M. Otto, C. Espiritu, A. Lam, 2011, Journal of Virology.

β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.

M. Otto, C. Espiritu, A. Lam, 2012, Bioorganic & medicinal chemistry letters.

Discovery of C-Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2.

S. Kultgen, Holly M. Micolochick Steuer, K. Stever, 2024, ACS infectious diseases.