Tony Whitaker

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The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

M. Otto, Haiying Bao, E. Murakami, 2007, Antimicrobial Agents and Chemotherapy.

Mechanism of Action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)thymine as an anti-HIV agent

Christopher M. Bailey, M. Otto, K. Anderson, 2007, Antiviral chemistry & chemotherapy.

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

R. Schinazi, Sijia Tao, A. Khalil, 2017, Journal of medicinal chemistry.

Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2',3'-dideoxy-2',2'-difluoro-4'-azanucleosides.

R. Schinazi, E. Theodorakis, S. Fernández, 2012, Bioorganic & medicinal chemistry.

Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections

M. I. Barrasa, C. Seeger, W. Mason, 2000, Journal of Virology.

Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections

M. I. Barrasa, C. Seeger, W. Mason, 2000, Journal of Virology.

Sofosbuvir (Sovaldi): The First‐in‐Class HCV NS5B Nucleotide Polymerase Inhibitor

R. Schinazi, Junxing Shi, Tony Whitaker, 2015 .

SYNTHESIS OF N3,5′-CYCLO-4-(β-D-RIBOFURANOSYL)-VIC-TRIAZOLO[4,5-b]PYRIDIN-5-ONE AND ITS 3′-DEOXYSUGAR ANALOGUE AS POTENTIAL ANTI-HEPATITIS C VIRUS AGENTS

M. Otto, L. Stuyver, R. Schinazi, 2005, Nucleosides, nucleotides & nucleic acids.

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Richard A. Stanton, R. Schinazi, Sijia Tao, 2016, Antimicrobial Agents and Chemotherapy.

Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2′-Deoxy-2′-Fluorocytidine

M. Otto, L. Stuyver, R. Schinazi, 2004, Antimicrobial Agents and Chemotherapy.

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

M. Otto, L. Stuyver, R. Schinazi, 2003, Antimicrobial Agents and Chemotherapy.

Asymmetric Binding to NS5A by Daclatasvir (BMS-790052) and Analogs Suggests Two Novel Modes of HCV Inhibition

Richard A. Stanton, J. Nettles, R. Schinazi, 2014, Journal of medicinal chemistry.

Synthesis and evaluation of novel potent HCV NS5A inhibitors.

R. Schinazi, Sijia Tao, F. Amblard, 2012, Bioorganic & medicinal chemistry letters.

β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.

R. Schinazi, Sijia Tao, M. Ehteshami, 2015, Journal of medicinal chemistry.

Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

M. Otto, L. Stuyver, R. Schinazi, 2007, Antimicrobial Agents and Chemotherapy.

Antiviral Activity of Nucleoside Analogues against Norovirus

R. Schinazi, J. Vinjé, L. Barclay, 2012, Antiviral therapy.

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.

R. Schinazi, F. Amblard, Long-hu Zhou, 2013, Bioorganic & medicinal chemistry letters.

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.

J. Courcambeck, R. Schinazi, P. Liu, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral evaluation of 2′,3′-dideoxy-2′,3′-difluoro-D-arabinofuranosyl 2,6-disubstituted purine nucleosides

R. Schinazi, F. Amblard, M. Detorio, 2015, Heterocyclic communications.

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.

R. Schinazi, Sijia Tao, M. Ehteshami, 2016, ACS medicinal chemistry letters.

Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.

R. Schinazi, Long-hu Zhou, M. Detorio, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides

César A. Urbina-Blanco, R. Schinazi, J. Balzarini, 2013, European Journal of Medicinal Chemistry.

Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.

Richard A. Stanton, J. Nettles, R. Schinazi, 2015, Bioorganic & medicinal chemistry letters.

Anti-hepatitis C Virus Activity of Novel β-D-2′-C-methyl-4′-azido Pyrimidine Nucleoside Phosphoramidate Prodrugs

R. Schinazi, Long-hu Zhou, Tony Whitaker, 2009, Antiviral chemistry & chemotherapy.

Synthesis and Antiviral Activity of Purine 2′,3′-Dideoxy-2′,3′-Difluoro-D-Arabinofuranosyl Nucleosides

R. Schinazi, M. Detorio, Tony Whitaker, 2009, Nucleosides, nucleotides & nucleic acids.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

M. Otto, L. Stuyver, R. Schinazi, 2004, Journal of medicinal chemistry.

Synthesis , evaluation of anti-HIV-1 and anti-HCV activity of novel 2 0 , 3 0-dideoxy-2 0 , 2 0-difluoro-4 0-azanucleosides

R. Schinazi, E. Theodorakis, S. Fernández, 2012 .

The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

M. Otto, Haiying Bao, E. Murakami, 2008, Antimicrobial agents and chemotherapy.

Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.

Steven J Coats, J. Mellors, R. Schinazi, 2010, Bioorganic & Medicinal Chemistry Letters.

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.

R. Schinazi, Megan H. Powdrill, M. Götte, 2011, Bioorganic & medicinal chemistry letters.

Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.

R. Schinazi, Emilie Fromentin, F. Amblard, 2009, European journal of medicinal chemistry.

Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2 (cid:2) -Deoxy-2 (cid:2) -Fluorocytidine

M. Otto, L. Stuyver, R. Schinazi, 2004 .

Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors.

R. Schinazi, P. Liu, F. Amblard, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.

R. Schinazi, Sijia Tao, Ozkan Sari, 2019, Journal of medicinal chemistry.

Significance of endangered and threatened plant natural products in the control of human disease

R. J. Doerksen, R. Schinazi, M. Hamann, 2013, Proceedings of the National Academy of Sciences.

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.

J. Nettles, R. Schinazi, F. Amblard, 2013, Bioorganic & medicinal chemistry letters.

Antiviral Activity of Nucleoside Analogues against Norovirus

R. Schinazi, J. Vinjé, L. Barclay, 2012, Antiviral therapy.

Short communication Anti-hepatitis C virus activity of novel β-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs

R. Schinazi, Long-hu Zhou, Tony Whitaker, 2009 .

Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2′-Deoxy-2′-Fluorocytidine

M. Otto, L. Stuyver, R. Schinazi, 2004, Antimicrobial Agents and Chemotherapy.