Yanan Zhang

发表

Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution.

Thuy-Ai T Nguyen, B. Thomas, J. Wiley, 2017, Journal of medicinal chemistry.

Toward the Development of Bivalent Ligand Probes of Cannabinoid CB1 and Orexin OX1 Receptor Heterodimers.

B. Thomas, B. Gilmour, Yanan Zhang, 2014, ACS medicinal chemistry letters.

Age-specific treatment effects of orexin/hypocretin-receptor antagonism on methamphetamine-seeking behavior.

M. Carroll, N. Zlebnik, Yanan Zhang, 2021, Drug and alcohol dependence.

Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I2 receptor agonist phenyzoline in adult male rats

Jun-Xu Li, Yanan Zhang, D. Thorn, 2017, Psychopharmacology.

Anti-hyperalgesic effects of imidazoline I2 receptor ligands in a rat model of inflammatory pain: interactions with oxycodone

J. Siemian, Jun-Xu Li, Yanan Zhang, 2015, Psychopharmacology.

Activation of trace amine‐associated receptor 1 attenuates nicotine withdrawal‐related effects

Ruyan Wu, Jun-Xu Li, Yanan Zhang, 2021, Addiction biology.

Overcoming the psychiatric side effects of the cannabinoid CB1 receptor antagonists: Current approaches for therapeutics development.

Thuy-Ai T Nguyen, B. Thomas, Yanan Zhang, 2019, Current topics in medicinal chemistry.

Mechanisms of imidazoline I2 receptor agonist‐induced antinociception in rats: involvement of monoaminergic neurotransmission

J. Siemian, Jun-Xu Li, Yanan Zhang, 2018, British journal of pharmacology.

Identification of neuropeptide S antagonists: structure-activity relationship studies, X-ray crystallography, and in vivo evaluation.

J. Deschamps, T. Fennell, R. Snyder, 2014, ACS chemical neuroscience.

Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats: antinociception and schedule-controlled responding

J. Siemian, Jun-Xu Li, Yanan Zhang, 2015, Psychopharmacology.

Towards rational design of cannabinoid receptor 1 (CB1) antagonists for peripheral selectivity.

K. Bortoff, R. Snyder, R. Maitra, 2011, Bioorganic & medicinal chemistry letters.

Design and synthesis of cannabinoid receptor 1 antagonists for peripheral selectivity.

K. Bortoff, T. Fennell, R. Snyder, 2012, Journal of medicinal chemistry.

Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior.

M. Glass, T. Gamage, David B. Finlay, 2021, Journal of medicinal chemistry.

Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)

B. Thomas, J. Wiley, B. Gilmour, 2014, Journal of medicinal chemistry.

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists.

V. Mavanji, C. Kotz, Dehui Zhang, 2021, Journal of medicinal chemistry.

Truncated Orexin Peptides: Structure-Activity Relationship Studies.

B. Thomas, B. Gilmour, N. German, 2013, ACS medicinal chemistry letters.

Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.

B. Thomas, B. Gilmour, D. Harris, 2013, Journal of medicinal chemistry.

Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor.

R. Snyder, S. Runyon, R. Wiethe, 2018, Journal of medicinal chemistry.

Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats

Qing Zhu, J. Siemian, Jun-Xu Li, 2019, Behavioural pharmacology.

Modified Synthesis of NOP Receptor Antagonist SB612111

Jun-Xu Li, Yanan Zhang, D. Perrey, 2016, Synthesis.

Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators.

Thuy-Ai T Nguyen, B. Thomas, T. Gamage, 2019, Journal of medicinal chemistry.

Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates.

F. Hsu, Thuy-Ai T Nguyen, H. Ding, 2020, British journal of anaesthesia.

MiR‐26a‐5p alleviates cardiac hypertrophy and dysfunction via targeting ADAM17

Fan Zhang, Q-H Han, Hongtao Shi, 2021, Cell biology international.

The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB1 receptor allosteric modulators

Thuy-Ai T Nguyen, B. Thomas, J. Wiley, 2017, Neuropharmacology.

TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKIIα activity in the NAc

D. Dietz, Ruyan Wu, Brad A. Grueter, 2022, Molecular Psychiatry.

Synthesis and Biological Evaluation of Bivalent Ligands for the CB1 Receptor

M. Damaj, B. Thomas, R. Maitra, 2011 .

Therapeutics development for addiction: Orexin-1 receptor antagonists

Yanan Zhang, D. Perrey, 2020, Brain Research.

The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.

S. Runyon, B. Thomas, B. Gilmour, 2015, Bioorganic & medicinal chemistry.

Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor.

S. Runyon, B. Thomas, B. Gilmour, 2015, ACS chemical neuroscience.

Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.

S. Runyon, B. Thomas, B. Gilmour, 2011, Bioorganic & medicinal chemistry letters.

Neuroanatomical characterization of imidazoline I2 receptor agonist‐induced antinociception

Shushan Jia, J. Siemian, Jun-Xu Li, 2018, The European journal of neuroscience.

Effects of the imidazoline I2 receptor agonist 2‐BFI on the development of tolerance to and behavioural/physical dependence on morphine in rats

Jun-Xu Li, Yanan Zhang, D. Thorn, 2016, British journal of pharmacology.

Antihyperalgesic effects of imidazoline I2 receptor ligands in rat models of inflammatory and neuropathic pain

Bi-Wen Peng, Jun-Xu Li, Yanan Zhang, 2014, British journal of pharmacology.

Structure-activity relationships and antiproliferative effects of 1,2,3,4-4H-quinoxaline derivatives as tubulin polymerization inhibitors.

Ya-hong Zhang, Yanan Zhang, Yungen Xu, 2021, Bioorganic chemistry.

In vitro and in vivo pharmacology of nine novel synthetic cannabinoid receptor agonists

J. Wiley, T. Gamage, Yanan Zhang, 2022, Pharmacology Biochemistry and Behavior.

Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018

M. Glass, B. Thomas, J. Wiley, 2022, Pharmacology research & perspectives.

Synthesis of Enantiopure PZM21, A Novel Biased Agonist of the Mu-Opioid Receptor.

Yanan, Thuy-Ai T Nguyen, F. Carroll, 2018, European journal of organic chemistry.

RTICBM-74 is a Brain-Penetrant CB1 Receptor Allosteric Modulator that Reduces Alcohol Intake in Rats

Thuy-Ai T Nguyen, J. Besheer, Yanan Zhang, 2021, bioRxiv.

Diarylureas Containing 5-Membered Heterocycles as CB1 Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation.

T. Kenakin, Thuy-Ai T Nguyen, B. Thomas, 2018, ACS chemical neuroscience.

Peripherally selective diphenyl purine antagonist of the CB1 receptor.

K. Bortoff, T. Fennell, R. Snyder, 2013, Journal of medicinal chemistry.

Role of intracellular Ca2+ signaling in the antinociceptive and discriminative stimulus effects of the imidazoline I2 receptor agonist 2-BFI in rats

J. Siemian, Jun-Xu Li, Yanan Zhang, 2017, Psychopharmacology.

Crosstalk between SUMOylated PPARγ1 and FOXO1 Exerts a Positive-feedback Effect on Vascular Endothelial Insulin Resistance

Qiren Huang, Guohua Zeng, M. Xia, 2021 .

Activation of trace amine‐associated receptor 1 selectively attenuates the reinforcing effects of morphine

Jingwei Tian, Ruyan Wu, Jun-Xu Li, 2020, British journal of pharmacology.

Effects of the cannabinoid CB₁ receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats.

L. Jing, Jun-Xu Li, Yanan Zhang, 2014, Drug and alcohol dependence.

Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats (658.2)

Jun-Xu Li, Yanan Zhang, D. Thorn, 2014, Behavioural pharmacology.

Selective TAAR1 agonists induce conditioned taste aversion

Ruyan Wu, Qing Zhu, Jun-Xu Li, 2022, Psychopharmacology.

Effects of the Trace Amine Associated Receptor 1 Agonist RO5263397 on Abuse-Related Behavioral Indices of Methamphetamine in Rats

L. Jing, Jun-Xu Li, Yanan Zhang, 2015, The international journal of neuropsychopharmacology.

Effects of the Trace Amine-Associated Receptor 1 Agonist RO5263397 on Abuse-Related Effects of Cocaine in Rats

D. Dietz, C. Galuska, Chad M. Galuska, 2014, Neuropsychopharmacology.

Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators.

T. Kenakin, Thuy-Ai T Nguyen, B. Thomas, 2015, Bioorganic & medicinal chemistry.

Characterization of the hypothermic effects of imidazoline I2 receptor agonists in rats

M. Pigini, X. An, Jun-Xu Li, 2012, British journal of pharmacology.

Effects of imidazoline I2 receptor agonists and morphine on schedule-controlled responding in rats

J. C. Winter, X. An, Jun-Xu Li, 2012, Pharmacology Biochemistry and Behavior.

Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.

J. C. Winter, Jun-Xu Li, Yanan Zhang, 2011, European journal of pharmacology.

Behavioral effects of the imidazoline I2 receptor ligand BU99006 in rats

Xiaohua He, Jun-Xu Li, Yanan Zhang, 2014, Behavioural pharmacology.

Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development.

Thuy-Ai T Nguyen, Jun-Xu Li, Yanan Zhang, 2020, Journal of medicinal chemistry.

Antinociceptive Interactions between the Imidazoline I2 Receptor Agonist 2-BFI and Opioids in Rats: Role of Efficacy at the μ-Opioid Receptor

J. Siemian, Jun-Xu Li, Yanan Zhang, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats.

Jun-Xu Li, Yanan Zhang, Y. Qiu, 2015, European journal of pharmacology.

Discriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats

Jun-Xu Li, Yanan Zhang, Y. Qiu, 2014, Scientific Reports.

Gender difference in epileptogenic effects of 2-BFI and BU224 in mice.

Xiaohua He, Bi-Wen Peng, Jun-Xu Li, 2013, European journal of pharmacology.

Effects of imidazoline I2 receptor ligands on acute nociception in rats

Jun-Xu Li, Yanan Zhang, C. Sampson, 2012, Neuroreport.

Effects of imidazoline I₂ receptor ligands on morphine- and tramadol-induced antinociception in rats.

J. C. Winter, Bi-Wen Peng, Jun-Xu Li, 2011, European journal of pharmacology.

Pyrazole antagonists of the CB1 receptor with reduced brain penetration.

K. Bortoff, R. Snyder, R. Wiethe, 2016, Bioorganic & medicinal chemistry.

Diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 antagonists.

K. Bortoff, T. Fennell, R. Snyder, 2012, Journal of medicinal chemistry.

Isoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects.

Y. Tao, R. Snyder, P. Patel, 2022, European journal of medicinal chemistry.

Neuropeptide B/W receptor 1 peptidomimetic agonists: Structure-activity relationships and plasma stability.

R. Snyder, T. Gamage, A. Decker, 2022, European journal of medicinal chemistry.

Identification of N-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

L. Gendron, James B. Thomas, S. Runyon, 2014, Journal of medicinal chemistry.

Conformationally constrained analogues of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): design, synthesis, computational analysis, and biological evaluations.

S. Mascarella, B. Thomas, M. Brackeen, 2008, Journal of medicinal chemistry.

Synthesis and Evaluation of Orexin-1 Receptor Antagonists with Improved Solubility and CNS Permeability.

A. Decker, Yanan Zhang, D. Perrey, 2017, ACS chemical neuroscience.

Metabolites of Dietary Acteoside: Profiles, Isolation, Identification, and Hepatoprotective Capacities.

Zhenzhong Wang, W. Xiao, Dongmei Wang, 2018, Journal of agricultural and food chemistry.

Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats: antinociception and schedule-controlled responding

J. Siemian, Jun-Xu Li, Yanan Zhang, 2016, Psychopharmacology.

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor

Thuy-Ai T Nguyen, B. Thomas, J. Wiley, 2017, Medicinal research reviews.

Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists.

Thuy-Ai T Nguyen, S. Runyon, D. Harris, 2017, ACS chemical neuroscience.

Cloning and characterization of steroid 5β-reductase from the venom gland of Bufo bufo gargarizans.

Mingyu Xia, Yanan Zhang, Dong Wang, 2021, International journal of biological macromolecules.

Role of trace amine-associated receptor 1 in nicotine’s behavioral and neurochemical effects

D. Dietz, Jinwoo Park, M. Hoener, 2018, Neuropsychopharmacology.

Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-seeking Behavior.

J. Siemian, Jun-Xu Li, Yanan Zhang, 2017, The Journal of neuroscience : the official journal of the Society for Neuroscience.

MiR-1955 p Promotes Cardiomyocyte Hypertrophy by Targeting MFN 2 and FBXW 7

Lei Wang, Q-H Han, Hongtao Shi, 2019 .

MiR-195-5p Promotes Cardiomyocyte Hypertrophy by Targeting MFN2 and FBXW7

Lei Wang, Q-H Han, Hongtao Shi, 2019, BioMed research international.

Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

L. Gendron, James B. Thomas, S. Runyon, 2014, Journal of medicinal chemistry.

Hypocretin Receptor 1 Regulation of Dopamine Neurotransmission and Motivated Behavior

R. España, J. Shaw, Yanan Zhang, 2019, The Orexin/Hypocretin System.

Methylphenidate modifies the motion of the circadian clock Lamotrigine in mood disorders and cocaine dependence Cortical glutamate in postpartum depression Effects of Suvorexant , a Dual Orexin / Hypocretin Receptor Antagonist , on Impulsive Behavior Associated with Cocaine

E. Brǎiloiu, S. J. Simmons, Taylor A. Gentile, 2017 .

Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement

L. Jing, Jun-Xu Li, Yanan Zhang, 2014 .

Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids.

M. Glass, Thuy-Ai T Nguyen, T. Gamage, 2021, Bioorganic & medicinal chemistry.

Tricyclic Pyrazoles. Part 5. Novel 1,4-Dihydroindeno[1,2-c]pyrazole CB2 Ligands Using Molecular Hybridization Based on Scaffold Hopping

P. Lazzari, B. Thomas, M. Falzoi, 2012, The open medicinal chemistry journal.

Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice.

B. Thomas, A. Mahadevan, J. Wiley, 2012, European journal of pharmacology.

Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

R. Snyder, S. Runyon, R. Uprety, 2021, Pharmaceuticals.

Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats

S. Runyon, N. Goeders, Christopher D. Schmoutz, 2012, Pharmacology Biochemistry and Behavior.

Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activity.

S. Runyon, H. Navarro, B. Gilmour, 2008, Bioorganic & medicinal chemistry letters.

Emerging drug targets for pain treatment.

Jun-Xu Li, Yanan Zhang, 2012, European journal of pharmacology.

The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice

Ruyan Wu, Jun-Xu Li, Yanan Zhang, 2021, Psychopharmacology.

Structure–Activity Relationships and Conformational Freedom of CB1 Receptor Antagonists and Inverse Agonists

B. Thomas, M. Brackeen, H. Seltzman, 2009 .

Imidazoline I2 receptors: target for new analgesics?

Jun-Xu Li, Yanan Zhang, 2011, European journal of pharmacology.

Behavioral effects of the cannabinoid CB1 receptor allosteric modulator ORG27569 in rats

L. Jing, Jun-Xu Li, Yanan Zhang, 2014, Pharmacology research & perspectives.

Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats

J. Siemian, Jun-Xu Li, Yanan Zhang, 2017, Behavioural pharmacology.

Propane-2-sulfonic acid octadec-9-enyl-amide, a novel peroxisome proliferator-activated receptors α and γ dual agonist, enhances hippocampal neurogenesis and neuroplasticity in rats with cerebral ischaemia.

Tong Ren, Juan Zhou, Maoshu Zhu, 2019, Neuroreport.

Effects of Trace Amine-associated Receptor 1 Agonists on the Expression, Reconsolidation, and Extinction of Cocaine Reward Memory

Jun-Xu Li, Yanan Zhang, Jian-Feng Liu, 2016, The international journal of neuropsychopharmacology.

The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats

Jun-Xu Li, Yanan Zhang, D. Thorn, 2014, Neuroscience Letters.

Hypocretin receptor 1 involvement in cocaine-associated behavior: Therapeutic potential and novel mechanistic insights

W. Xu, S. Kortagere, Z. Brodnik, 2020, Brain Research.

The effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the Orexin-1 receptor

S. Runyon, B. Thomas, B. Gilmour, 2015 .

TAAR1 agonists attenuate extended‐access cocaine self‐administration and yohimbine‐induced reinstatement of cocaine‐seeking

Ruyan Wu, Qing Zhu, Jun-Xu Li, 2020, British journal of pharmacology.

Role of trace amine‑associated receptor 1 in the medial prefrontal cortex in chronic social stress-induced cognitive deficits in mice.

T. Si, Yanan Zhang, Yun-Ai Su, 2021, Pharmacological research.

Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.

M. Damaj, B. Thomas, R. Maitra, 2010, Journal of medicinal chemistry.

Effects of a trace amine-associated receptor 1 agonist RO 5263397 on ethanol-induced behavioral sensitization

Ruyan Wu, Jun-Xu Li, Yanan Zhang, 2020, Behavioural Brain Research.

Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior

J. Siemian, Jun-Xu Li, Yanan Zhang, 2017, The Journal of Neuroscience.

Effect of family nutrition therapy on elderly patients with chronic obstructive pulmonary disease

Yanan Zhang, Zhaohe Song, Baoyin Bo, 2020 .

The imidazoline I2 receptor agonist 2‐BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain

P. Paez, Jingwei Tian, V. Spreuer, 2018, Biochemical pharmacology.

Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats

L. Jing, Jun-Xu Li, Yanan Zhang, 2014 .

Methamphetamine-induced impulsivity during chronic methamphetamine treatment in rats: Effects of the TAAR 1 agonist RO5263397

J. Siemian, Jun-Xu Li, Yanan Zhang, 2018, Neuropharmacology.