J. Gavrilyuk

发表

Anti-HIV-1 Antibodies and CD 4-IgG Breadth and Potency of Neutralization of Antibody Conjugation Approach Enhances

C. Barbas, D. Burton, M. Seaman, 2013 .

Antibody Conjugation Approach Enhances Breadth and Potency of Neutralization of Anti-HIV-1 Antibodies and CD4-IgG

C. Barbas, D. Burton, M. Seaman, 2013, Journal of Virology.

Potent Inhibition of HIV‐1 Entry with a Chemically Programmed Antibody Aided by an Efficient Organocatalytic Synthesis

C. Barbas, D. Burton, A. Hessell, 2010, Chembiochem : a European journal of chemical biology.

Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics.

K. Nicolaou, M. Aujay, J. Lyssikatos, 2020, Journal of the American Chemical Society.

ABBV-011, A Novel, Calicheamicin-Based Antibody–Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors

W. Wiedemeyer, Zhaomei Zhang, P. Vitorino, 2022, Molecular cancer therapeutics.

Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates.

K. Nicolaou, V. Sisodiya, Qifeng Chen, 2020, Journal of the American Chemical Society.

Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents.

K. Nicolaou, M. Aujay, Christina Lee, 2018, Journal of the American Chemical Society.

Formylbenzene diazonium hexafluorophosphate reagent for tyrosine-selective modification of proteins and the introduction of a bioorthogonal aldehyde.

C. Barbas, W. Hakamata, M. Nagano, 2012, Bioconjugate chemistry.

Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.

K. Nicolaou, M. Aujay, D. Vourloumis, 2018, Journal of the American Chemical Society.

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins.

K. Nicolaou, M. Aujay, D. Vourloumis, 2016, Journal of the American Chemical Society.

Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues.

K. Nicolaou, M. Aujay, S. Kishigami, 2019, The Journal of organic chemistry.

Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.

K. Nicolaou, M. Aujay, S. Rigol, 2017, Journal of the American Chemical Society.

Lewis Acid catalyzed three-component hetero-Diels-alder (povarov) reaction of N-arylimines with strained norbornene-derived dienophiles.

R. Batey, A. Lough, Chris D. Smith, 2010, The Journal of organic chemistry.

Facile and stabile linkages through tyrosine: bioconjugation strategies with the tyrosine-click reaction.

C. Barbas, W. Hakamata, M. Nagano, 2013, Bioconjugate chemistry.

Tyrosine bioconjugation through aqueous ene-type reactions: a click-like reaction for tyrosine.

C. Barbas, Carlos F. Barbas, Hitoshi Ban, 2010, Journal of the American Chemical Society.

Peptide-heterocycle hybrid molecules: solid-phase-supported synthesis of substituted N-terminal 5-aminotetrazole peptides via electrocyclization of peptidic imidoylazides.

R. Batey, G. Evindar, J. Gavrilyuk, 2007, Journal of combinatorial chemistry.

Synthesis and Biological Investigation of Δ(12)-Prostaglandin J3 (Δ(12)-PGJ3) Analogues and Related Compounds.

K. Nicolaou, M. Aujay, M. Brönstrup, 2016, Journal of the American Chemical Society.

Covalent binders in drug discovery.

Noel S. Wilson, A. Hobson, A. Vasudevan, 2019, Progress in medicinal chemistry.

Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues.

K. Nicolaou, M. Aujay, Yogesh G Shelke, 2020, The Journal of organic chemistry.

Stereoselective Synthesis of Trisubstituted Ole fi nic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design , Synthesis , and Biological Evaluation of Potent Antitumor Agents

K. Nicolaou, M. Aujay, E. Hamel, 2017 .

Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2.

C. Barbas, Ulrich Wuellner, J. Gavrilyuk, 2009, Bioorganic & medicinal chemistry letters.

Parallel solution phase synthesis of a library of amino acid derived 2-arylamino-[1,3,4]-oxadiazoles

R. Batey, A. Lough, J. Gavrilyuk, 2008 .

Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole Analogues.

Zhaomei Zhang, K. Nicolaou, M. Aujay, 2020, Journal of the American Chemical Society.

Uncialamycin-based antibody–drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect

M. Aujay, M. Pysz, H. Karsunky, 2021, Proceedings of the National Academy of Sciences.

Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs

A. Stepan, K. Nicolaou, D. Vourloumis, 2016, ChemMedChem.

Preparation and activities of macromolecule conjugates of the CCR5 antagonist Maraviroc.

C. Barbas, D. Burton, Shigehiro Asano, 2014, ACS medicinal chemistry letters.

Evaluation of PNU-159682 antibody drug conjugates (ADCs).

V. Sisodiya, Samuel A. Williams, M. Aujay, 2020, Bioorganic & medicinal chemistry letters.

Expanding the concept of chemically programmable antibodies to RNA aptamers: chemically programmed biotherapeutics.

C. Barbas, Ulrich Wuellner, J. Gavrilyuk, 2010, Angewandte Chemie.

An efficient chemical approach to bispecific antibodies and antibodies of high valency.

C. Barbas, Ulrich Wuellner, S. Sinha, 2009, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.

K. Nicolaou, B. Nocek, M. Aujay, 2021, The Journal of organic chemistry.