J. Shaw

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Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis.

D. Brown, J. G. Cumming, S. Wells, 2012, Bioorganic & medicinal chemistry letters.

University of Birmingham A novel mechanism of neutrophil recruitment in a co-culture model of the rheumatoid synovium

A. Filer, C. Buckley, G. Nash, 2012 .

ICI 204448: a κP‐opioid agonist with limited access to the CNS

P. Alcock, J. Shaw, J. Carroll, 1989 .

Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium.

C. Buckley, G. Nash, H. McGettrick, 2008, Arthritis and rheumatism.

Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists.

T. Blackburn, K. Russell, J. Shaw, 1991, Journal of medicinal chemistry.

Analgesia following intravenous administration of enkephalin analogues

J. Morley, J. Shaw, G. J. Stacey, 2006 .

The coexistence of adenosine A1 and A2 receptors in guinea-pig aorta.

J. Shaw, S. M. Stoggall, 1990, European journal of pharmacology.

Duffy Antigen Receptor for Chemokines (DARC) and CXCL5 are essential for the recruitment of neutrophils in a multi-cellular model of the RA synovium

C. Buckley, G. Nash, H. McGettrick, 2012 .

14 – Approaches to Novel Anti-arthritic Drugs by Modulation of the Arachidonic Acid Cascade

R. McMillan, S. J. Foster, J. Shaw, 1995 .

Differential sensitivity of antinociceptive assays to the bradykinin antagonist Hoe 140

C. Heapy, J. Shaw, S. Farmer, 1993, British journal of pharmacology.

2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists.

J. Shaw, G. Costello, A. M. Slater, 1991, Journal of medicinal chemistry.

Mu-receptor binding in physiological media: Comparison with isolated tissue data

C. Downes, J. Shaw, J. Carroll, 1984, Neuropeptides.

The contribution of intrinsic activity to the action of opioids in vitro

J. Shaw, L. Miller, E. Whiting, 1986, British journal of pharmacology.

Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals.

N. Bowery, A. Hudson, A. Doble, 1981, European journal of pharmacology.

The xanthene-9-spiro-4'-piperidine nucleus as a probe for opiate activity.

J. Shaw, R. J. Pearce, Z. Matusiak, 1989, Journal of medicinal chemistry.

(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

D. Middlemiss, N. Bowery, A. Hudson, 1980, Nature.

Conversion of dynorphin-(1-9) to [Leu5]enkephalin by the mouse vas deferens in vitro.

J. Traynor, J. Shaw, M. J. Rance, 1985, European journal of pharmacology.

Failure of substance P to produce analgesia in the mouse [proceedings].

J. Growcott, J. Shaw, 1979, British journal of pharmacology.

ICI 174864: A highly selective antagonist for the opioid Δ-receptor

M. Giles, D. Timms, J. Shaw, 1984 .

Selective antagonists at the opiate delta-receptor.

J. Morley, J. Shaw, J. J. Gormley, 1982, Life sciences.

Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.

John G Cumming, Jeremy N Burrows, J. G. Cumming, 2005, Bioorganic & medicinal chemistry letters.

A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium.

A. Filer, C. Buckley, G. Nash, 2005, Arthritis and rheumatism.

Multiple opiate receptors in the mouse vas deferens.

J. Shaw, L. Miller, 1983, European journal of pharmacology.

The physiological relevance of low agonist affinity binding at opioid μ‐receptors

A. Wickenden, J. Shaw, J. Carroll, 1988, British journal of pharmacology.

Characterization of opiate receptors in the isolated rat rectum [proceedings].

J. Shaw, 1979, British journal of pharmacology.

ICI 204448: a kappa-opioid agonist with limited access to the CNS.

P. Alcock, J. Shaw, J. Carroll, 1989, British journal of pharmacology.

In vitro profile of some opioid pentapeptide analogues.

J. Shaw, M. Turnbull, 1978, European journal of pharmacology.

In vivo evaluation of the opiate delta receptor antagonist ICI 154, 129.

J. Morley, T. Priestley, J. Shaw, 1982, Life sciences.

Baclofen: a selective agonist for a novel type of GABA receptor proceedings.

N. Bowery, A. Hudson, A. Doble, 1979, British journal of pharmacology.

ICI 174864: a highly selective antagonist for the opioid delta-receptor.

M. Giles, D. Timms, J. Shaw, 1984, European journal of pharmacology.

Dopaminergic drugs antagonize the psychotomimetic effects of partial-agonist analgesics

J. Shaw, W. Buckett, 1975, Psychopharmacologia.

Differential sensitivity of antinociceptive tests to opioid agonists and partial agonists

J. Shaw, Janet D. Rourke, Karen M. Burns, 1988, British journal of pharmacology.

A novel series of potent and selective agonists at the opioid κ-receptor

Gerard F. Costello, Brain G. Main, Jeffrey J. Barlow, 1988 .

Phototoxicity and fluorotoxicity combine to alter the behavior of neutrophils in fluorescence microscopy based flow adhesion assays

C. Buckley, G. Nash, J. Shaw, 2006, Microscopy research and technique.

Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides.

Simon J Brown, D. Whittaker, J. G. Cumming, 2006, Bioorganic & medicinal chemistry letters.

Mu-receptors in the C57BL mouse vas deferens

J. Shaw, L. Miller, 1984, Neuropeptides.

Enkephalin analogues eliciting analgesia after intravenous injection.

J. Morley, M. Turnbull, J. Shaw, 1977, Life sciences.

A simple device for measurement of respiratory rate in the mouse [proceedings].

J. Shaw, G. B. Horsfall, M. Turnbull, 1977, British Journal of Pharmacology.

Specificity of the opioid affinity reagent, DALECK, in a set of isolated tissue assay systems

E. Barnard, J. Shaw, E. Peers, 1986, Neuropeptides.

Failure to demonstrate mu-isoreceptors

J. Shaw, J. Rourke, 1984, Neuropeptides.

Characterisation of the δ-opioid receptor on the hamster vas deferens

J. Shaw, L. Miller, 1985, Neuropeptides.

Selective defects in T cell function in ataxia-telangiectasia.

J. Shaw, W. Levis, A. Dattner, 1979, Clinical and experimental immunology.

Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides.

D. Whittaker, J. G. Cumming, K. Grime, 2005, Bioorganic & medicinal chemistry letters.