Rena Nishizawa

Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.

H. Mitsuya, K. Maeda, H. Nakai, 2011, Bioorganic & medicinal chemistry.

Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite.

H. Mitsuya, K. Maeda, M. Toda, 2007, Bioorganic & medicinal chemistry letters.

Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate.

H. Mitsuya, K. Maeda, W. Kazmierski, 2011, Bioorganic & medicinal chemistry letters.

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.

H. Mitsuya, K. Maeda, K. Hirai, 2010, Bioorganic & medicinal chemistry.

Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.

H. Mitsuya, K. Maeda, K. Hirai, 2010, Bioorganic & medicinal chemistry letters.

Stereocontrolled synthesis and reactivity of sugar acetylenes

M. Isobe, T. Nishikawa, S. Hosokawa, 1999 .

Hydrosilylation of acetylenes with catalytic biscobalthexacarbonyl complex and its application to heteroconjugate addition methodology

M. Isobe, T. Nishikawa, K. Yoza, 1999 .

Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats.

W. Kazmierski, R. Ferris, F. Deanda, 2011, Bioorganic & medicinal chemistry letters.