D. Fukushima

发表

Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.

H. Mitsuya, K. Maeda, H. Nakai, 2011, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.

H. Mitsuya, K. Maeda, M. Toda, 2006, Journal of medicinal chemistry.

Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite.

H. Mitsuya, K. Maeda, M. Toda, 2007, Bioorganic & medicinal chemistry letters.

Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.

K. Suzuki, S. Ishiura, K. Maruyama, 1993, Biochemical and biophysical research communications.

Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate.

H. Mitsuya, K. Maeda, W. Kazmierski, 2011, Bioorganic & medicinal chemistry letters.

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.

H. Mitsuya, K. Maeda, K. Hirai, 2010, Bioorganic & medicinal chemistry.

Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.

H. Mitsuya, K. Maeda, K. Hirai, 2010, Bioorganic & medicinal chemistry letters.

NEW SYNTHESES OF THIONITRITES AND THEIR CHEMICAL REACTIVITIES

S. Ōae, Yong Hae Kim, D. Fukushima, 1978 .

New syntheses of thionitrites and their chemical reactivites

S. Ōae, Yong Hae Kim, D. Fukushima, 1978 .

Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5*

Hiroaki Mitsuya, Kazuhisa Yoshimura, H. Mitsuya, 2001, The Journal of Biological Chemistry.

Enzymatic oxidation of disulfides and thiolsulfinates by both rabbit liver microsomes and a reconstituted system with purified cytochrome P-450.

T. Iyanagi, S. Ōae, D. Fukushima, 1978, Journal of biochemistry.

The oxidation of unsymmetrical thiolsufinate : evidence for α-disulfoxide as an intermediate

T. Takata, S. Ōae, Yong Hae Kim, 1977 .

Novel method of activating thiols by their conversion into thionitrites with dinitrogen tetroxide

S. Ōae, Yong Hae Kim, D. Fukushima, 1977 .

Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro

H. Mitsuya, K. Maeda, Y. Koh, 2004, Journal of Virology.

Functional micelles. 8. Micellar catalysis of the hydrolysis of substituted phenyl carboxylates by imidazole containing cationic surfactants

D. Fukushima, W. Tagaki, Y. Yano, 1979 .

Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release.

Y. Okada, M. Pierschbacher, K. Imai, 1997, The Biochemical journal.

A 60-kD protein mediates the binding of transforming growth factor-beta to cell surface and extracellular matrix proteoglycans

E Ruoslahti, E. Ruoslahti, D. Twardzik, 1993, The Journal of cell biology.