Ajay Guru

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Tryptophan-tagged peptide from serine threonine-protein kinase of Channa striatus improves antioxidant defence in L6 myotubes and attenuates caspase 3–dependent apoptotic response in zebrafish larvae

J. Arockiaraj, A. Arshad, P. Elumalai, 2021, Fish Physiology and Biochemistry.

Molecular Docking of SA11, RF13 and DI14 Peptides from Vacuolar Protein Sorting Associated Protein 26B Against Cancer Proteins and In vitro Investigation of its Anticancer Potency in Hep-2 Cells

J. Arockiaraj, A. A. Hatamleh, Ajay Guru, 2022, International Journal of Peptide Research and Therapeutics.

Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: Possible mechanism of nephroprotection.

J. Arockiaraj, R. Mothana, R. Pachaiappan, 2022, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Neuroprotective and antioxidant capability of RW20 peptide from histone acetyltransferases caused by oxidative stress-induced neurotoxicity in in vivo zebrafish larval model

J. Arockiaraj, A. A. Hatamleh, R. Harikrishnan, 2022, Journal of King Saud University - Science.

Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model

J. Arockiaraj, P. Gopinath, Mikhlid H. Almutairi, 2022, Molecular and Cellular Biochemistry.

Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle.

Palaniselvam Kuppusamy, J. Arockiaraj, P. Gopinath, 2022, Life sciences.

Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae

J. Arockiaraj, Ajay Guru, Melita J Juliet, 2022, Environmental toxicology.

Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae

J. Arockiaraj, P. Gopinath, A. A. Hatamleh, 2022, Brain Research.

Deteriorating insulin resistance due to WL15 peptide from cysteine and glycine‐rich protein 2 in high glucose‐induced rat skeletal muscle L6 cells

J. Arockiaraj, N. Saraswathi, P. Issac, 2021, Cell biology international.

Long non‐coding RNA , a supreme post‐transcriptional immune regulator of bacterial or virus‐driven immune evolution in teleost

J. Arockiaraj, A. Arshad, Ajay Guru, 2022, Reviews in Aquaculture.

NV14 from serine O‐acetyltransferase of cyanobacteria influences the antioxidant enzymes in vitro cells, gene expression against H2O2 and other responses in vivo zebrafish larval model

M. Arasu, N. Al-Dhabi, J. Arockiaraj, 2021, Cell biology international.

Neuroprotective effect of Biochanin a against Bisphenol A-induced prenatal neurotoxicity in zebrafish by modulating oxidative stress and locomotory defects

J. Arockiaraj, Mikhlid H. Almutairi, R. Pachaiappan, 2022, Neuroscience Letters.

Deacetylepoxyazadiradione Derived from Epoxyazadiradione of Neem (Azadirachta indica A. Juss) Fruits Mitigates LPS‐Induced Oxidative Stress and Inflammation in Zebrafish Larvae

J. Arockiaraj, P. Gopinath, Mikhlid H. Almutairi, 2022, Chemistry & biodiversity.

Lantibiotics: an antimicrobial asset in combating aquaculture diseases

J. Arockiaraj, A. Arshad, Ajay Guru, 2022, Aquaculture International.

Anti‐inflammatory role demonstrated both in vitro and in vivo models using nonsteroidal tetranortriterpenoid, Nimbin (N1) and its analogs (N2 and N3) that alleviate the domestication of alternative medicine

M. Arasu, N. Al-Dhabi, J. Arockiaraj, 2022, Cell biology international.

Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model.

M. Arasu, N. Al-Dhabi, A. Freddy, 2020, Developmental and comparative immunology.

β-cells regeneration by WL15 of cysteine and glycine-rich protein 2 which reduces alloxan induced β-cell dysfunction and oxidative stress through phosphoenolpyruvate carboxykinase and insulin pathway in zebrafish in-vivo larval model

J. Arockiaraj, Mikhlid H. Almutairi, Ajay Guru, 2022, Molecular Biology Reports.

Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine‐rich protein 2

J. Arockiaraj, Ajay Guru, 2022, Journal of biochemical and molecular toxicology.

Pro-inflammatory cytokine molecules from Boswellia serrate suppresses lipopolysaccharides induced inflammation demonstrated in an in-vivo zebrafish larval model

J. Arockiaraj, Mikhlid H. Almutairi, Ajay Guru, 2022, Molecular Biology Reports.

Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels.

J. Arockiaraj, N. Bhuvanesh, P. Gopinath, 2022, Toxicology and applied pharmacology.

Syringol, a wildfire residual methoxyphenol causes cytotoxicity and teratogenicity in zebrafish model.

Palaniselvam Kuppusamy, J. Arockiaraj, R. Pachaiappan, 2022, The Science of the total environment.

Molecular properties of postbiotics and their role in controlling aquaculture diseases

J. Arockiaraj, A. Arshad, Ajay Guru, 2022, Aquaculture Research.

Protective effect of morin by targeting mitochondrial reactive oxygen species induced by hydrogen peroxide demonstrated at a molecular level in MDCK epithelial cells

J. Arockiaraj, R. Pachaiappan, Pachaiappan Raman, 2022, Molecular Biology Reports.

Pathogenicity and Pathobiology of Epizootic Ulcerative Syndrome (EUS) Causing Fungus Aphanomyces invadans and Its Immunological Response in Fish

J. Arockiaraj, A. Arshad, P. Elumalai, 2020 .

Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds

J. Arockiaraj, A. Arshad, N. Saraswathi, 2020, Molecular Biology Reports.

Double‐edged sword role of shrimp miRNA explains an evolutionary language between shrimp‐pathogen interactions that unties the knot of shrimp infection

J. Arockiaraj, A. Arshad, Ajay Guru, 2021, Reviews in Aquaculture.

Evidence-based hormonal, mutational, and endocrine-disrupting chemical-induced zebrafish as an alternative model to study PCOS condition similar to mammalian PCOS model.

J. Arockiaraj, A. Arshad, Ajay Guru, 2022, Life sciences.

Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells

M. Arasu, N. Al-Dhabi, K. Choi, 2021, Molecular Biology Reports.

Anti-Cancer and Anti-Inflammatory Activities of a Short Molecule, PS14 Derived from the Virulent Cellulose Binding Domain of Aphanomyces invadans, on Human Laryngeal Epithelial Cells and an In Vivo Zebrafish Embryo Model

K. Al-Ghanim, J. Arockiaraj, S. Muthupandian, 2022, Molecules.

GR15 peptide of S-adenosylmethionine synthase (SAMe) from Arthrospira platensis demonstrated antioxidant mechanism against H2O2 induced oxidative stress in in-vitro MDCK cells and in-vivo zebrafish larvae model.

M. Arasu, N. Al-Dhabi, J. Arockiaraj, 2021, Journal of biotechnology.

Nano-sized aggregation induced emissive probe for highly sensitive hypochlorous acid detection

M. Velusamy, J. Arockiaraj, A. Kathiravan, 2022, Dyes and Pigments.

Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing therapeutic implications.

M. Arasu, N. Al-Dhabi, J. Arockiaraj, 2021, Life sciences.

Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach.

Palaniselvam Kuppusamy, J. Arockiaraj, P. Gopinath, 2022, Microbial pathogenesis.

Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway involved in the PCOS zebrafish

J. Arockiaraj, S. Muthupandian, P. Gopinath, 2022, Phytotherapy research : PTR.

Role and mechanistic actions of protein kinase inhibitors as an effective drug target for cancer and COVID

J. Arockiaraj, S. Muthupandian, J. Narayanan, 2023, Archives of Microbiology.

Molecular process of glucose uptake and glycogen storage due to hamamelitannin via insulin signalling cascade in glucose metabolism

M. Arasu, N. Al-Dhabi, J. Arockiaraj, 2020, Molecular Biology Reports.

Plausible antioxidant and anticonvulsant potential of brain targeted naringenin-conjugated graphene oxide nanoparticles

J. Arockiaraj, S. Arokiyaraj, G. Mukesh, 2023, Biomass Conversion and Biorefinery.

Nimbin analogs N5 and N7 regulate the expression of lipid metabolic genes and inhibit lipid accumulation in high-fat diet-induced zebrafish larvae: An antihyperlipidemic study.

M. Arasu, J. Arockiaraj, Ajay Guru, 2022, Tissue & cell.

PS9, Derived from an Aquatic Fungus Virulent Protein, Glycosyl Hydrolase, Arrests MCF-7 Proliferation by Regulating Intracellular Reactive Oxygen Species and Apoptotic Pathways

M. Arasu, N. Al-Dhabi, T. Ahamad, 2023, ACS omega.

Lipid-Lowering and Antioxidant Activity of RF13 Peptide From Vacuolar Protein Sorting-Associated Protein 26B (VPS26B) by Modulating Lipid Metabolism and Oxidative Stress in HFD Induced Obesity in Zebrafish Larvae

J. Arockiaraj, Ajay Guru, Manikandan Velayutham, 2022, International Journal of Peptide Research and Therapeutics.

6‐Gingerol and Semisynthetic 6‐Gingerdione Counteract Oxidative Stress Induced by ROS in Zebrafish

P. Gopinath, Ajay Guru, Tamilvelan Manjunathan, 2021, Chemistry & biodiversity.

Copper sulfate induced toxicological impact on in-vivo zebrafish larval model protected due to acacetin via anti-inflammatory and glutathione redox mechanism.

F. Al-Misned, S. Mahboob, K. Al-Ghanim, 2022, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

GP13, an Arthrospira platensis cysteine desulfurase-derived peptide, suppresses oxidative stress and reduces apoptosis in human leucocytes and zebrafish (Danio rerio) embryo via attenuated caspase-3 expression

J. Arockiaraj, A. Farasani, P. Sarkar, 2021, Journal of King Saud University - Science.

6‐Gingerdione Reduces Apoptotic Conditions in HepG2 Cells and Inhibits Inflammatory Cytokine Gene Expression in Alcoholic Liver Injured Zebrafish Larvae

J. Arockiaraj, P. Gopinath, Ajay Guru, 2022, Chemistry & biodiversity.

A synthetic antioxidant molecule, GP13 derived from cysteine desulfurase of spirulina, Arthrospira platensis exhibited anti-diabetic activity on L6 rat skeletal muscle cells through GLUT-4 pathway

J. Arockiaraj, Mukesh Pasupuleti, P. Sarkar, 2022, Journal of King Saud University - Science.

Nimbin (N1) and analog N3 from the neem seeds suppress the migration of osteosarcoma MG-63 cells and arrest the cells in a quiescent state mediated via activation of the caspase-modulated apoptotic pathway

J. Arockiaraj, S. Arokiyaraj, Nada H. Aljarba, 2023, Molecular Biology Reports.

A Review on Mitochondrial Derived Peptide Humanin and Small Humanin-Like Peptides and Their Therapeutic Strategies

J. Arockiaraj, P. Issac, Ajay Guru, 2023, International Journal of Peptide Research and Therapeutics.

Circular RNA ciRS-7 signature as a potential biomarker for the early detection of diabetes with Alzheimer’s disease: a hypothesis

J. Arockiaraj, Ajay Guru, Raghul Murugan, 2023, Molecular Biology Reports.

Gut-Brain Axis a Key Player to Control Gut Dysbiosis in Neurological Diseases.

J. Arockiaraj, P. Issac, Ajay Guru, 2023, Molecular neurobiology.

Ophthalmic Intervention of Naringenin Decreases Vascular Endothelial Growth Factor by Counteracting Oxidative Stress and Cellular Damage in In Vivo Zebrafish

G. Téllez-Isaías, J. Arockiaraj, R. Pachaiappan, 2023, Molecules.

Hazards of polycyclic aromatic hydrocarbons: a review on occurrence, detection, and role of green nanomaterials on the removal of PAH from the water environment

J. Arockiaraj, P. Issac, Ajay Guru, 2023, Environmental Monitoring and Assessment.

The bioaccessibility of adsorped heavy metals on biofilm-coated microplastics and their implication for the progression of neurodegenerative diseases

J. Arockiaraj, P. Issac, Ajay Guru, 2023, Environmental Monitoring and Assessment.

Exploring the Combined Effect of Exercise and Apigenin on Aluminium-Induced Neurotoxicity in Zebrafish.

J. Arockiaraj, R. Pachaiappan, Ajay Guru, 2024, Molecular neurobiology.

A Review on Mitochondrial Derived Peptide Humanin and Small Humanin-Like Peptides and Their Therapeutic Strategies

J. Arockiaraj, P. Issac, Ajay Guru, 2023, International Journal of Peptide Research and Therapeutics.

Synergetic Effects of Polyethylene Microplastic and Abamectin Pesticides on the Eyes of Zebrafish Larvae and Adults Through Activation of Apoptosis Signaling Pathways.

A. Rady, G. Malafaia, Ajay Guru, 2023, Environmental toxicology and pharmacology.

JAK2/STAT3 as a new potential target to manage neurodegenerative diseases: An interactive review.

Adarsh Kesharwani, Ajay Guru, S. P. Panda, 2024, European journal of pharmacology.

Interconnected environmental challenges: heavy metal-drug interactions and their impacts on ecosystems.

J. Arockiaraj, Ajay Guru, Gokul Sudhakaran, 2024, Drug and chemical toxicology.

Selenium Nanoparticles as Neuroprotective Agents: Insights into Molecular Mechanisms for Parkinson's Disease Treatment.

J. Arockiaraj, P. Issac, Ajay Guru, 2024, Molecular neurobiology.

Synergistic berberine chloride and Curcumin-Loaded nanofiber therapies against Methicillin-Resistant Staphylococcus aureus Infection: Augmented immune and inflammatory responses in zebrafish wound healing.

J. Arockiaraj, Ajay Guru, Haroon Khan, 2024, International immunopharmacology.