H. Shimizu

发表

The Leishmania Surface Protease GP63 Cleaves Multiple Intracellular Proteins and Actively Participates in p38 Mitogen-activated Protein Kinase Inactivation*

W. McMaster, M. Tremblay, M. Olivier, 2009, Journal of Biological Chemistry.

Microcystin-LR incorporated into colonic cells through probenecid-sensitive transporters leads to upregulated MCP-1 expression induced by JNK activation

K. Shimizu, N. Sugiura, Keisuke Yoshikiyo, 2022, Toxicology reports.

Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone

S. Ishizuka, S. Fukiya, A. Yokota, 2015, Bioscience, biotechnology, and biochemistry.

Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation.

S. Ishizuka, Shinya Tanaka, H. Miyazaki, 2014, American journal of physiology. Cell physiology.

Hepatocyte nuclear factor 1β induced by chemical stress accelerates cell proliferation and increases genomic instability in mouse liver

S. Nakasono, T. Negishi, H. Shimizu, 2011, Journal of receptor and signal transduction research.

Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation.

S. Ishizuka, H. Hara, S. Fukiya, 2015, Toxicology letters.

Indoxyl sulfate counteracts endothelial effects of erythropoietin through suppression of Akt phosphorylation.

T. Niwa, H. Shimizu, R. Mironova, 2013, Circulation journal : official journal of the Japanese Circulation Society.

A low coefficient of variation in hepatic triglyceride concentration in an inbred rat strain

S. Ishizuka, Shota Hori, H. Shimizu, 2020, Lipids in Health and Disease.

Correlation between 12α-hydroxylated bile acids and insulin secretion during glucose tolerance tests in rats fed a high-fat and high-sucrose diet

S. Ishizuka, Shota Hori, H. Shimizu, 2020, Lipids in Health and Disease.

Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet

S. Ishizuka, S. Fukiya, A. Yokota, 2019, Bioscience, biotechnology, and biochemistry.

AST-120 ameliorates epithelial-to-mesenchymal transition and interstitial fibrosis in the kidneys of chronic kidney disease rats.

T. Niwa, H. Shimizu, Dilinaer Bolati, 2012, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

Indoxyl Sulfate Induces Epithelial-to-Mesenchymal Transition in Rat Kidneys and Human Proximal Tubular Cells

T. Niwa, H. Shimizu, F. Nishijima, 2011, American Journal of Nephrology.

Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon

S. Ishizuka, Jae-Sung Lee, H. Hara, 2014, Bioscience, biotechnology and biochemistry.

Deoxycholic acid is involved in the proliferation and migration of vascular smooth muscle cells.

S. Ishizuka, H. Hara, S. Fukiya, 2014, Journal of nutritional science and vitaminology.

Receptor-Type Protein Tyrosine Phosphatase ϵ (PTPϵM) is a Negative Regulator of Insulin Signaling in Primary Hepatocytes and Liver

N. Aoki, H. Shimano, N. Yamada, 2005 .

Indoxyl sulfate induces endothelial cell senescence by increasing reactive oxygen species production and p53 activity.

T. Niwa, H. Shimizu, Gulinuer Muteliefu, 2012, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells.

A. Enomoto, T. Niwa, H. Shimizu, 2011, American journal of physiology. Cell physiology.

Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.

A. Enomoto, T. Niwa, H. Shimizu, 2010, American journal of physiology. Cell physiology.

ROS and PDGF-beta [corrected] receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration.

Y. Hirose, H. Miyazaki, Y. Tsubakihara, 2009, American journal of physiology. Cell physiology.

12α-Hydroxylated bile acid enhances accumulation of adiponectin and immunoglobulin A in the rat ileum

S. Ishizuka, K. Tada, Shota Hori, 2021, Scientific Reports.

Low Mr protein tyrosine phosphatase inhibits growth and migration of vascular smooth muscle cells induced by platelet-derived growth factor

K. Miyazaki, N. Ishida, Shokei Kim, 2001 .

Indoxyl sulfate induces nephrovascular senescence.

T. Niwa, H. Shimizu, 2012, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats.

T. Niwa, H. Shimizu, F. Nishijima, 2011, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

Indoxyl Sulfate Downregulates Renal Expression of Klotho through Production of ROS and Activation of Nuclear Factor-ĸB

A. Enomoto, T. Niwa, H. Shimizu, 2011, American Journal of Nephrology.

Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells.

N. Aoki, H. Miyazaki, Y. Nakagawa, 2010, American journal of physiology. Cell physiology.

Protein tyrosine phosphatase PTP ε M negatively regulates PDGF (cid:1) -receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells

N. Aoki, H. Miyazaki, Y. Nakagawa, 2010 .

Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells.

K. Shimizu, T. Niwa, H. Shimizu, 2012, Life sciences.

Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats.

T. Niwa, H. Shimizu, F. Nishijima, 2010, Biochemical and biophysical research communications.

Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet

S. Ishizuka, H. Hara, Kimiko Minamida, 2016, British Journal of Nutrition.

Influence of AHRR Pro189Ala polymorphism on kidney functions

S. Ishizuka, T. Niwa, K. Tada, 2017, Bioscience, biotechnology, and biochemistry.

Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.

K. Nishimura, M. Jisaka, K. Yokota, 2019, Biochemical and biophysical research communications.

Protein Tyrosine Phosphatase LMW-PTP Exhibits Distinct Roles Between Vascular Endothelial and Smooth Muscle Cells

M. Shiota, H. Miyazaki, S. Kim‐Mitsuyama, 2005, Journal of receptor and signal transduction research.

Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src.

M. Shiota, H. Miyazaki, Y. Nakagawa, 2004, Biochemical and biophysical research communications.

Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress.

Masahide Takahashi, A. Enomoto, T. Niwa, 2012, American journal of physiology. Cell physiology.

Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats.

A. Enomoto, T. Niwa, Maimaiti Yisireyili, 2013, Life sciences.

Cellular functions of mitogen-activated protein kinases and protein tyrosine phosphatases in ovarian granulosa cells.

T. Miyano, H. Miyazaki, H. Shimizu, 2004, The Journal of reproduction and development.

Combined Treatment of Hydroxytyrosol with Carbon Monoxide-Releasing Molecule-2 Prevents TNFα-Induced Vascular Endothelial Cell Dysfunction through NO Production with Subsequent NFκB Inactivation

Houda Zrelli, H. Miyazaki, H. Shimizu, 2013, BioMed research international.

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB

T. Niwa, Maimaiti Yisireyili, H. Shimizu, 2013, BMC Nephrology.

Co-ingestion with γ-cyclodextrin improves bioavailability of α-linolenic acid in Perilla frutescens seed oil

Keita Iwasaki, Keisuke Yoshikiyo, Edward G. Nagato, 2023, Food Hydrocolloids for Health.

Thermal stability and bioavailability of inclusion complexes of perilla oil with γ-cyclodextrin.

Tatsuyuki Yamamoto, Keisuke Yoshikiyo, Yuriko Yoshioka, 2019, Food chemistry.

Prostaglandin D2 Added during the Differentiation of 3T3-L1 Cells Suppresses Adipogenesis via Dysfunction of D-Prostanoid Receptor P1 and P2

K. Nishimura, M. Jisaka, K. Yokota, 2023, Life.

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

H. Sone, H. Shimano, N. Yahagi, 2014, Endocrinology.

Dietary supplementation with okara and Bacillus coagulans lilac-01 improves hepatic lipid accumulation induced by cholic acids in rats

S. Ishizuka, Kimiko Minamida, K. Tada, 2022, Journal of Functional Foods.

Indoxyl Sulfate Enhances p53-TGF-β1-Smad3 Pathway in Proximal Tubular Cells

T. Niwa, Maimaiti Yisireyili, H. Shimizu, 2013, American Journal of Nephrology.

Arachidonic Acid Added during the Differentiation Phase of 3T3-L1 Cells Exerts Anti-Adipogenic Effect by Reducing the Effects of Pro-Adipogenic Prostaglandins

K. Nishimura, M. Jisaka, K. Yokota, 2023, Life.

Indoxyl Sulfate Upregulates Expression of ICAM-1 and MCP-1 by Oxidative Stress-Induced NF-ĸB Activation

A. Enomoto, T. Niwa, H. Miyazaki, 2010, American Journal of Nephrology.

CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells.

T. Niwa, H. Shimizu, F. Nishijima, 2013, American journal of physiology. Cell physiology.

Comparison of pro-adipogenic effects between prostaglandin (PG) D2 and its stable, isosteric analogue, 11-deoxy-11-methylene-PGD2, during the maturation phase of cultured adipocytes.

K. Nishimura, M. Jisaka, K. Yokota, 2018, Prostaglandins & other lipid mediators.

ROS and PDFG- (cid:1) receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration

H. Miyazaki, Y. Tsubakihara, H. Shimizu, 2009 .

Tropomyosin micelles are the major components contributing to the white colour of boiled shellfish soups

S. Matsumoto, T. Akihiro, Keisuke Yoshikiyo, 2022, Scientific Reports.

12α-hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats.

Tetsuya Hayashi, S. Ishizuka, S. Fukiya, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells.

T. Niwa, Maimaiti Yisireyili, H. Shimizu, 2013, Life sciences.

Indoxyl sulfate upregulates prorenin expression via nuclear factor-κB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells.

T. Niwa, Maimaiti Yisireyili, H. Shimizu, 2015, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.

A. Enomoto, T. Niwa, Maimaiti Yisireyili, 2014, Endocrinology.

Stat3 Contributes to Indoxyl Sulfate-Induced Inflammatory and Fibrotic Gene Expression and Cellular Senescence

T. Niwa, Maimaiti Yisireyili, H. Shimizu, 2012, American Journal of Nephrology.

Indoxyl sulfate upregulates renal expression of icam-1 via production of ros and activation of nf-κb and p53 in proximal tubular cells

T. Niwa, H. Shimizu, 2012 .

Prostaglandin D2 and its analog, 11d-11m-PGD2, added during the differentiation phase contribute to adipogenic program inhibition in 3T3-L1 cells.

K. Nishimura, M. Jisaka, K. Yokota, 2022, Bioscience, biotechnology, and biochemistry.

A novel strategy of selective gene delivery by using a uniform magnetic field

K. Takishima, H. Shimizu, M. Arai, 2020, Biotechnology journal.

A novel strategy for selective gene delivery by using the inhibitory effect of blue light on jetPRIME‐mediated transfection

K. Takishima, H. Shimizu, M. Arai, 2016, Biotechnology and bioengineering.