O. Sivak

发表

Assessment of novel oral lipid-based formulations of amphotericin B using an in vitro lipolysis model.

P. Gershkovich, E. Wasan, K. Wasan, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines.

C. Constantinescu, P. Fischer, D. Barrett, 2016, American journal of translational research.

Effect of hypertriglyceridemia on the pharmacokinetics and blood–brain barrier penetration of clozapine and norclozapine following administration to rats

P. Gershkovich, A. Barr, K. Wasan, 2010, European Neuropsychopharmacology.

NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration.

O. L. Moritz, K. Gregory-Evans, C. Gregory‐Evans, 2016, Human molecular genetics.

Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.

P. Gershkovich, E. Wasan, K. Wasan, 2009, The Journal of antimicrobial chemotherapy.

Unidirectional Inhibition of Lipid Transfer Protein I-Mediated Transfer of Cholesteryl Esters Between High-Density and Low-Density Lipoproteins by Amphotericin B Lipid Complex

K. Wasan, O. Sivak, B. Lau, 2004, Pharmaceutical Research.

Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans.

P. Gershkovich, E. Wasan, K. Bartlett, 2009, International journal of pharmaceutics.

ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer

A. Zoubeidi, Sylvan C. Baca, M. Freedman, 2022, Nature Communications.

Assessment of cholesterol absorption inhibitors nanostructured aluminosilicate and cholestyramine using in vitro lipolysis model.

P. Gershkovich, K. Wasan, O. Sivak, 2012, Journal of pharmaceutical sciences.

Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet

P. Gershkovich, P. Constantinides, K. Wasan, 2009, Lipids in Health and Disease.

Assessing the Antifungal Activity of a New Oral Lipid-Based Amphotericin B Formulation Following Administration to Rats Infected with Aspergillus Fumigatus

K. Bartlett, K. Wasan, O. Sivak, 2007, Drug development and industrial pharmacy.

Assessing the antifungal activity, pharmacokinetics, and tissue distribution of amphotericin B following the administration of Abelcet and AmBisome in combination with caspofungin to rats infected with Aspergillus fumigatus.

K. Bartlett, K. Wasan, O. Sivak, 2007, Journal of pharmaceutical sciences.

Assessing the antifungal activity and toxicity profile of amphotericin B lipid complex (ABLC; Abelcet) in combination with caspofungin in experimental systemic aspergillosis.

F. Marra, K. Bartlett, K. Wasan, 2004, Journal of pharmaceutical sciences.

Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet

P. Gershkovich, P. Constantinides, K. Wasan, 2009, Lipids in Health and Disease.

Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men

Y. Wong, D. Rossignol, N. Aikawa, 2012, Innate immunity.

Assessing Lipid Lowering and Plasma Cholesteryl Ester Transfer Protein Activity of Simvastatin Following Administration to Rabbits Fed a High Fat/Cholesterol Diet

K. Wasan, Stephen D. Lee, O. Sivak, 2006, Drug development and industrial pharmacy.

Influence of Plasma Cholesterol and Triglyceride Concentrations and Eritoran (E5564) Micelle Size on its Plasma Pharmacokinetics and Ex Vivo Activity Following Single Intravenous Bolus Dose Into Healthy Female Rabbits

D. Rossignol, K. Wasan, Stephen D. Lee, 2007, Pharmaceutical Research.

Plasma protein binding, lipoprotein distribution and uptake of free and lipid-associated BCL-2 antisense oligodeoxynucleotides (G3139) in human melanoma cells.

M. Bally, E. Wasan, K. Wasan, 2002, International journal of pharmaceutics.

In vivo study and thermodynamic investigation of two lanthanum complexes, La(dpp)3 and La(XT), for the treatment of bone resorption disorders† †Electronic supplementary information (ESI) available: Speciation diagrams for metal–ligand complexes (Fig. S1 and S3), ITC analysis of H5XT-hydroxyapatite t

C. Haynes, A. Creagh, K. Wasan, 2015, Chemical science.

Association of the Endotoxin Antagonist E5564 with High-Density Lipoproteins In Vitro: Dependence on Low-Density and Triglyceride-Rich Lipoprotein Concentrations

D. Rossignol, W. Christ, K. Wasan, 2003, Antimicrobial Agents and Chemotherapy.

A simple and sensitive method for determination of vitamins D3 and K1 in rat plasma: application for an in vivo pharmacokinetic study

P. Gershkovich, K. Wasan, Fady Ibrahim, 2014, Drug development and industrial pharmacy.

Discovery and characterization of a first-in-field transcription factor BRN2 inhibitor for the treatment of neuroendocrine prostate cancer

A. Zoubeidi, H. Beltran, C. Morrissey, 2022, bioRxiv.

Efficacy of Postnatal In Vivo Nonsense Suppression Therapy in a Pax6 Mouse Model of Aniridia

K. Gregory-Evans, C. Gregory‐Evans, K. Wasan, 2017, Molecular therapy. Nucleic acids.

Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice.

P. Gershkovich, E. Wasan, Xiaohua Zhu, 2010, The Journal of antimicrobial chemotherapy.

Biodistribution and tissue toxicity of amphotericin B in mice following multiple dose administration of a novel oral lipid-based formulation (iCo-009).

P. Gershkovich, E. Wasan, K. Wasan, 2010, The Journal of antimicrobial chemotherapy.

Efficacy and toxicity of a tropically stable lipid-based formulation of amphotericin B (iCo-010) in a rat model of invasive candidiasis.

P. Gershkovich, E. Wasan, K. Bartlett, 2012, International journal of pharmaceutics.

Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model

P. Gershkovich, E. Wasan, K. Wasan, 2011, Lipids in Health and Disease.

Heat-Treated Fungizone Retains Amphotericin B Antifungal Activity Without Renal Toxicity in Rats Infected with Aspergillus Fumigatus

K. Bartlett, K. Wasan, O. Sivak, 2004, Pharmaceutical Research.

Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats

P. Gershkovich, E. Wasan, K. Wasan, 2013, Drug development and industrial pharmacy.

An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer

H. G. van der Poel, Faraz Hach, M. Gleave, 2021, Nature Cell Biology.

Abstract 1295: First-in-field small molecule inhibitors targeting BRN2 as a therapeutic strategy for small cell prostate cancer

A. Zoubeidi, H. Beltran, L. Puca, 2019, Experimental and Molecular Therapeutics.

Discovery and Development of Toll-Like Receptor 4 (TLR4) Antagonists: A New Paradigm for Treating Sepsis and Other Diseases

K. Wasan, C. Leon, O. Sivak, 2008, Pharmaceutical Research.

Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols.

Katayoun Saatchi, U. Häfeli, P. Gershkovich, 2012, International journal of pharmaceutics.

Simultaneous determination of a novel antitrypanosomal compound (OSU-36) and its ester derivative (OSU-40) in plasma by HPLC: application to first pharmacokinetic study in rats.

P. Gershkovich, K. Wasan, K. Werbovetz, 2011, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Impact of co-administration of protonated nanostructured aluminum silicate (cholesterol absorption inhibitor) on the absorption of lipid soluble vitamins D3 and K1: an assessment of pharmacokinetic and in vitro intraluminal processing.

A. Midha, K. Wasan, J. Gordon, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Modifications in Lipoprotein Surface Charge Alter Cyclosporine A Association with Low-Density Lipoproteins

K. Wasan, O. Sivak, 2004, Pharmaceutical Research.

Cyclosporine A transfer between high- and low-density lipoproteins: independent from lipid transfer protein I-facilitated transfer of lipoprotein-coated phospholipids because of high affinity of cyclosporine a for the protein component of lipoproteins.

K. Wasan, O. Sivak, E. Kwong, 2001, Journal of pharmaceutical sciences.

The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)

T. Rades, A. Müllertz, K. Wasan, 2015, The AAPS Journal.

Novel oral amphotericin B formulation (iCo-010) remains highly effective against murine systemic candidiasis following exposure to tropical temperature

P. Gershkovich, E. Wasan, K. Bartlett, 2015, Drug development and industrial pharmacy.

Efficacy of an oral and tropically stable lipid-based formulation of Amphotericin B (iCo-010) in an experimental mouse model of systemic candidiasis

E. Wasan, K. Bartlett, K. Wasan, 2013, Lipids in Health and Disease.

ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer.

A. Zoubeidi, Dwaipayan Ganguli, M. Kobelev, 2023, Cell reports.