U. Hanumegowda

发表

Modeling Liver Biology and the Tissue Response to Injury in Bioprinted Human Liver Tissues

K. Retting, Chirag B Khatiwala, L. Lehman-Mckeeman, 2018, Applied In Vitro Toxicology.

Maturation Inhibitor with Improved Potency, Anti-viral Spectrum and Gag Polymorphic

N. Meanwell, Zeyu Lin, M. Krystal, 2016 .

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

N. Meanwell, Zeyu Lin, M. Krystal, 2016, Antimicrobial Agents and Chemotherapy.

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.

A. Mathur, J. Cutrone, N. Meanwell, 2017, Bioorganic & medicinal chemistry letters.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury.

M. Shibuya, B. Copple, P. Ganey, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Thrombin and Protease-Activated Receptor-1 Agonists Promote Lipopolysaccharide-Induced Hepatocellular Injury in Perfused Livers

B. Copple, P. Ganey, R. Roth, 2003, Journal of Pharmacology and Experimental Therapeutics.

Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure.

P. Ganey, R. Roth, J. Hotchkiss, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Drug-Induced Phospholipidosis: Prediction, Detection, and Mitigation Strategies

U. Hanumegowda, A. Regueiro-Ren, 2013 .

Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.

K. Kish, N. Meanwell, M. Krystal, 2022, Bioorganic & medicinal chemistry.

Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.

K. Kish, N. Meanwell, C. Cianci, 2022, ACS medicinal chemistry letters.

Secalonic acid D alters the nature of and inhibits the binding of the transcription factors to the phorbol 12-O-tetradecanoate-13 acetate-response element in the developing murine secondary palate.

C. Reddy, U. Hanumegowda, G. Balasubramanian, 2000, Toxicology and applied pharmacology.

Assessing the risk of drug crystallization in vivo.

E. Janovitz, D. Drexler, S. Ruepp, 2019, Journal of pharmacological and toxicological methods.

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.

N. Meanwell, J. Lemm, K. Yeung, 2017, ACS medicinal chemistry letters.

Mechanism of secalonic acid D-induced inhibition of transcription factor binding to cyclic AMP response element in the developing murine palate.

V. C. Dhulipala, C. Reddy, U. Hanumegowda, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.

B. Beno, K. Kish, S. Sheriff, 2017, MedChemComm.

Relevance of the palatal protein kinase A pathway to the pathogenesis of cleft palate by secalonic acid D in mice.

V. C. Dhulipala, C. Reddy, U. Hanumegowda, 2004, Toxicology and applied pharmacology.

Selective inhibition of murine palatal mesenchymal cell proliferation in vitro by secalonic acid D.

W. Welshons, C. Reddy, B. Judy, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Systemic Loss of C-terminal Src Kinase Expression Elicits Spontaneous Suppurative Inflammation in Conditional Knockout Mice

E. Janovitz, S. Wee, G. Cantor, 2018, Veterinary pathology.

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Chong-Hwan Chang, M. Witmer, B. Beno, 2014, Journal of medicinal chemistry.

The Role of Drug Metabolism in Toxicity

C. Davis, U. Hanumegowda, 2010 .

Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5.

J. Macor, Amy Easton, Anand Balakrishnan, 2016, ACS medicinal chemistry letters.

Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure.

M. Shibuya, B. Copple, P. Ganey, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.

Qi Gao, Min Gao, Steven Sheriff, 2017, Journal of medicinal chemistry.

Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.

N. Meanwell, J. Lemm, J. Kadow, 2016, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

Phospholipidosis as a function of basicity, lipophilicity, and volume of distribution of compounds.

J. Corradi, R. Yordanova, S. Adams, 2010, Chemical research in toxicology.

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

N. Meanwell, Zeyu Lin, M. Krystal, 2018, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.

K. Kish, N. Meanwell, H. Lewis, 2022, Journal of medicinal chemistry.

Second Generation Inhibitors of HIV-1 Maturation.

N. Meanwell, I. Dicker, U. Hanumegowda, 2019, ACS medicinal chemistry letters.

Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds.

S. Adams, D. Connors, U. Hanumegowda, 2009, Toxicology in vitro : an international journal published in association with BIBRA.

Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.

B. Beno, N. Meanwell, M. Krystal, 2021, Bioorganic & medicinal chemistry letters.

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.

N. Meanwell, M. Krystal, Tricia L. Protack, 2016, Bioorganic & medicinal chemistry letters.

Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential.

J. Macor, Amy Easton, Anand Balakrishnan, 2016, Bioorganic & medicinal chemistry letters.

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

A. Mathur, N. Meanwell, Zeyu Lin, 2022, Journal of medicinal chemistry.

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.

N. Meanwell, Zeyu Lin, M. Krystal, 2022, Journal of Medicinal Chemistry.