R. Prehn

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Theoretical Biology and Medical Modelling Open Access Does the Immune Reaction Cause Malignant Transformation by Disrupting Cell-to-cell or Cell-to-matrix Communications? Tumor Progression

R. Prehn, 2022 .

Theoretical Biology and Medical Modelling Open Access Immunostimulation and Immunoinhibition of Premalignant Lesions

R. Prehn, 2022 .

The autoimmune nature of cancer.

R. Prehn, L. Prehn, 1987, Cancer research.

The dose-response curve in tumor-immunity.

R. Prehn, 1983, International journal of immunopharmacology.

Improvement of Antitumor Therapies Based on Vaccines and Immune-Checkpoint Inhibitors by Counteracting Tumor-Immunostimulation

D. Montagna, R. Ruggiero, O. Bustuoabad, 2018, Front. Oncol..

A new kink in an old theory of carcinogenesis

R. Prehn, L. Prehn, 2013, Theoretical Biology and Medical Modelling.

Immunity to methylcholanthrene-induced sarcomas.

R. Prehn, J. Main, 1957, Journal of the National Cancer Institute.

Is an immune reaction required for malignant transformation and cancer growth?

R. Prehn, L. Prehn, 2012, Cancer Immunology, Immunotherapy.

The Initial Immune Reaction to a New Tumor Antigen Is Always Stimulatory and Probably Necessary for the Tumor's Growth

R. Prehn, 2010, Clinical & developmental immunology.

Cancer may be caused by the Immune Reaction

R. Prehn, 2008 .

Immunostimulation of the lymphodependent phase of neoplastic growth.

R. Prehn, 1977, Journal of the National Cancer Institute.

Many growth factors may not be growth factors.

R. Prehn, 1992, Cancer research.

Tumor progression and homeostasis.

R. Prehn, 1976, Advances in cancer research.

CANCER AS AN AUTOIMMUNE DISEASE

R. Prehn, L. Prehn, 2006 .

Genetic susceptibility to post-thymectomy autoimmune diseases in mice

R. Prehn, A. Kojima, 1981, Immunogenetics.

Antigenic diversity of tumors chemically induced within the progeny of a single cell

R. Prehn, Miguel Angel Basombrí, 1972, International journal of cancer.

Immunological Tolerance to Many Self Epitopes may be Unnecessary

R. Prehn, 1990, Scandinavian journal of immunology.

On the nature of cancer and why anticancer vaccines don't work

R. Prehn, 2005, Cancer Cell International.

The Concept of the Immune Reaction in Oncogenesis: A Host Tumor Interaction

R. Prehn, H. Outzen, 1989 .

Growth of cells in vivo in diffusion chambers. I. Survival of homografts in immunized mice.

G. H. Algire, R. Prehn, J. M. Weaver, 1954, Journal of the National Cancer Institute.

Whipsaw cancer treatments: the role of hormesis in endocrine and immune therapies.

D. Berd, R. Prehn, 2006, Seminars in oncology.

Surveillance, latency and the two levels of MCA‐induced tumor immunogenicity

R. Prehn, G. L. Bartlett, 1987, International journal of cancer.

Relationship of tumor immunogenicity to concentration of the oncogen.

R. Prehn, 1975, Journal of the National Cancer Institute.

Tumor inhibitory T cell immunity may be largely a transplantation artifact not necessarily dependent upon a lack of Tregs

R. Prehn, L. Prehn, 2013, Theoretical Biology and Medical Modelling.

Cancer immunotherapy by immunosuppression

R. Prehn, L. Prehn, 2010, Theoretical Biology and Medical Modelling.

Immunologgical self-tolerance in allophenic and embryo-aggregated mice

R. Prehn, L. Prehn, 2010, Theoretical Biology and Medical Modelling.

Tumor-specific Antigens of Putatively Nonviral Tumors 1

R. Prehn, 2006 .

Theoretical Biology and Medical Modelling Open Access an Immune Reaction May Be Necessary for Cancer Development

R. Prehn, 2022 .

The flip side of tumor immunity.

R. Prehn, L. Prehn, 1989, Archives of surgery.

Immunological surveillance versus immunological stimulation of oncogenesis--a formal proof of the stimulation hypothesis.

R. Prehn, 1982, Advances in experimental medicine and biology.

Do Tumors Grow because of the Immune Response of the Host?

R. Prehn, Richmond T. Prehn, 1976, Transplantation reviews.

Immunological Surveillance: Pro and Con1

R. Prehn, 1974 .

Tumor-specific antigens of putatively nonviral tumors.

R. Prehn, 1968, Cancer research.

Tumor-specific antigens and the homograft reaction.

R. Prehn, 1963, American journal of surgery.

SPECIFIC ISOANTIGENICITIES AMONG CHEMICALLY INDUCED TUMORS *

R. Prehn, 1962 .

C O M M E N T a R Y Open Access

R. Prehn, L. Prehn, 2022 .

The paradoxical effects of splenectomy on tumor growth

R. Prehn, 2006, Theoretical Biology and Medical Modelling.

Tumor-specific antigens as altered growth factor receptors.

R. Prehn, 1989, Cancer research.

Splenic variations affecting sarcomagenesis among mice of an inbred strain

R. Prehn, C. Karcher, Christina Karcher, 1983, International journal of cancer.

Nongenetic variability in susceptibility to oncogenesis

R. Prehn, 1975, Science.

The predictive value of skin allograft survival times during the development of urethan-induced lung adenomas in BALB-c mice.

R. Prehn, M. Lappé, 1970, Cancer research.

THE RELATIONSHIP OF IMMUNOLOGY TO CARCINOGENESIS *

R. Prehn, 1969, Annals of the New York Academy of Sciences.

Role of the Fibrous Capsule in Carcinogenesis by Plastic Film

R. Bates, R. Prehn, RICHMOND T. PREHN, 1965, Nature.

The growth of cells in vivo in diffusion chambers. II. The role of cells in the destruction of homografts in mice.

G. H. Algire, R. Prehn, J. M. Weaver, 1955, Journal of the National Cancer Institute.

Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow.

R. Prehn, J. Main, 1955, Journal of the National Cancer Institute.

Sequential in vitro reactivity of lymphocytes from melanoma patients receiving immunotherapy compared with the reactivity of lymphocytes from healthy donors

M. Mastrangelo, R. Prehn, A. Bodurtha, 1975, International journal of cancer.

Two competing influences that may explain concomitant tumor resistance.

R. Prehn, 1993, Cancer research.

Stimulation of liver regeneration and compensatory kidney hyperplasia by passive transfer of spleen cells.

R. Prehn, M. Pliskin, 1975, Journal of the Reticuloendothelial Society.

Pathobiology of Neoplasia

R. Prehn, 2007 .

Number of mouse histocompatibility genes involved in skin grafting from strain BALB/cAn to strain DBA/2.

R. Prehn, J. Main, 1958, Journal of the National Cancer Institute.

The Autoimmune Nature of Cancer 1

R. Prehn, L. Prehn, 2006 .

Immunostimulation of chemical oncogenesis in the mouse

R. Prehn, 1977, International journal of cancer.

Letter: Immunosurveillance of naturally occurring feline leukemia.

R. Prehn, 1976, Science.

The diffusion-chamber technique applied to a study of the nature of homograft resistance.

G. H. Algire, R. Prehn, J. M. Weaver, 1954, Journal of the National Cancer Institute.

The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.

R. Prehn, 1996, Cancer research.

Role of Tumor Antigens in the Biology of Neoplasia

R. Prehn, 1972 .

An Immunostimulation Theory of Tumor Development

R. Prehn, M. Lappé, 1971, Transplantation reviews.

The Immune Reaction as a Stimulator of Tumor Growth

R. Prehn, 1972, Science.

Clinical and immunological significance of human melanoma cytotoxic antibody.

M. Mastrangelo, R. Prehn, A. Bodurtha, 1975, Cancer research.

Clinical and Immunological Significance of Human Melanoma Cytotoxic 1

M. Mastrangelo, R. Prehn, A. Bodurtha, 2022 .

Immunotherapy: the need for critical studies.

R. Prehn, J. Yarbro, R. Bornstein, 1972, Annals of internal medicine.

Perspectives on oncogenesis: does immunity stimulate or inhibit neoplasia?

R. Prehn, 1971, Journal of the Reticuloendothelial Society.

Tumor inhibitory T cell immunity may be largely a transplantation artifact not necessarily dependent upon a lack of Tregs

R. Prehn, L. Prehn, 2013, Theoretical Biology and Medical Modelling.

A new kink in an old theory of carcinogenesis

R. Prehn, L. Prehn, 2013, Theoretical Biology and Medical Modelling.

The flip side of immune surveillance: immune dependency

R. Prehn, L. Prehn, 2008, Immunological reviews.

Immunomodulation of tumor growth.

R. Prehn, 1974, The American journal of pathology.

Effect of treatment with dimethyl triazeno imidazole carboxamide (DTIC, NSC-45388) or 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU, NSC-409962) plus vincristine (NSC-67574) on lymphocyte reactivity of melanoma patients

M. Mastrangelo, R. Prehn, J. Berkelhammer, 1977, Cancer Immunology, Immunotherapy.

Cancer antigens in tumors induced by chemicals.

R. Prehn, 1965, Federation proceedings.

Influence of X irradiation and the milk agent on growth of transplanted mouse mammary tumors.

R. Prehn, 1969, Journal of the National Cancer Institute.

Tumor Antigens, Carcinogen Induced

R. W. Baldwin, R. Prehn, 1971 .

Immunosurveillance, Regeneration and Oncogenesis1

R. Prehn, 1971 .

Immunosurveillance, regeneration and oncogenesis.

R. Prehn, 1971, Progress in experimental tumor research.

FUNCTION OF DEPRESSED IMMUNOLOGIC REACTIVITY DURING CARCINOGENESIS.

R. Prehn, 1963, Journal of the National Cancer Institute.

Chemoimmunotherapy increases the lymphocyte reactivity of melanoma patients.

D. Berd, M. Mastrangelo, R. Bellet, 1979, European journal of cancer.

Regeneration versus neoplastic growth.

R. Prehn, 1997, Carcinogenesis.

STUDIES ON TISSUE HOMOTRANSPLANTATION IN MICE, USING DIFFUSION‐CHAMBER METHODS

G. H. Algire, R. Prehn, J. M. Weaver, 1957, Annals of the New York Academy of Sciences.

A CLONAL SELECTION THEORY OF CHEMICAL CARCINOGENESIS.

R. Prehn, 1964, Journal of the National Cancer Institute.

Differential Toxicity Response of Normal and Neoplastic Cells In Vitro to 3,4-Benzopyrene and 3-Methylcholanthrene

A. Globerson, R. Prehn, L. Alfred, 1964, British Journal of Cancer.

Book Review The Society of Cells: Cancer and control of cell proliferation By C. Sonnenschein and A.M. Soto. 154 pp. New York, Springer-Verlag, 1999. $34.95. 0-387-91583-4

R. Prehn, 1999 .

Clinical and histologic correlation of melanoma regression after intralesional BCG therapy: a case report.

M. Mastrangelo, R. Prehn, J. Yarbro, 1974, Journal of the National Cancer Institute.

Fate of skin homografts in x-irradiated mice treated with homologous marrow.

R. Prehn, J. Main, 1957, Journal of the National Cancer Institute.

Cancer and the immune response.

R. Prehn, 1973, The Proceedings of the Institute of Medicine of Chicago.

Rate‐limiting step in the progression of mouse breast tumors

R. Prehn, 1977, International journal of cancer.

Stimulatory effects of immune reactions upon the growths of untransplanted tumors.

R T Prehn, R. Prehn, 1994, Cancer research.

Differential susceptibility of the axilla and groin of the mouse to chemical oncogenesis

R. Prehn, V. Karnik, 1979, Nature.

Factors influencing tumor distribution among the mammary glands of the mouse.

M. Schneiderman, R. Prehn, J. Main, 1954, Journal of the National Cancer Institute.

Specific homograft tolerance induced by successive matings and implications concerning choriocarcinoma.

R. Prehn, 1960, Journal of the National Cancer Institute.

On the prevention and therapy of prostate cancer by androgen administration.

R. Prehn, 1999, Cancer Research.

Cancers beget mutations versus mutations beget cancers.

R T Prehn, R. Prehn, 1994, Cancer research.

The role of mutation in the new cancer paradigm

R. Prehn, 2005, Cancer Cell International.

CANCERS BEGET MUTATIONS characteristic alterations in glucose metabolism , and a reproducible pattern of iron and heme metabolismâ€

R. Prehn, 2006 .

Analysis of antigenic heterogeneity within individual 3-methylcholanthrene-induced mouse sarcomas.

R. Prehn, 1970, Journal of the National Cancer Institute.

The inhibition of tumor growth by tumor mass.

R T Prehn, R. Prehn, 1991, Cancer research.

Transfer of the mammary tumor milk agent from implant to host.

R. Prehn, 1952, Journal of the National Cancer Institute.

ARE TUMOR‐ASSOCIATED TRANSPLANTATION ANTIGENS OF CHEMICALLY INDUCED SARCOMAS RELATED TO ALIEN HISTOCOMPATIBILITY ANTIGENS?

R. Prehn, M. Pliskin, 1978, Transplantation.

Does the absence of immunologic surveillance affect the tumor incidence in "nude" mice? First recorded spontaneous lymphoma in a "nude" mouse.

R. Custer, R. Prehn, H. Outzen, 1973, Journal of the National Cancer Institute.

Invasion and metastasis of a xenogeneic tumor in nude mice.

R. Custer, R. Prehn, H. Outzen, 1976, Journal of the National Cancer Institute.

Intralesional BCG in the treatment of metastatic malignant melanoma

M. Mastrangelo, R. Prehn, J. Yarbro, 1976, Cancer.

Immunotherapy of melanoma with intralesional BCG.

M. Mastrangelo, R. Prehn, J. Yarbro, 1973, National Cancer Institute monograph.

Tumor-specific Immunity to Transplanted Dibenz[a,h]-anthracene-induced Sarcomas

R. Prehn, 1960 .

anmracene-inaucea @arcomas

R. Prehn, 2017 .

Tumor immunogenicity: how far can it be pushed?

R. Prehn, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Spontaneous and induced tumor incidence in germfree "nude" mice.

R. Custer, R. Prehn, H. Outzen, 1975, Journal of the Reticuloendothelial Society.

Peritoneal macrophage response to leukemia L1210 in syngeneic mice.

D. Berd, R. Prehn, 1977, Journal of the National Cancer Institute.

Influence of immune status of host on immunogenicity of tumors induced with two doses of methylcholanthrene

R. Prehn, E. M. Lawler, 2004, Cancer Immunology, Immunotherapy.

Alteration of cell-mediated immunity in the mouse following administration of 4-nitroquinoline 1-oxide.

R. Prehn, H. Outzen, 1973, Cancer research.

Studies on the basis for diversity and time of appearance of antigens in chemically induced tumors.

R. Prehn, M. A. Basombrío, 1972, National Cancer Institute monograph.

Effect of different immunization and challenge procedures on in vivo tumor immunogenicity tests

R. Prehn, H. Outzen, E. M. Lawler, 1981, Cancer Immunology, Immunotherapy.

The epigenetic instruction manual for the operation of the genome.

R. Prehn, 2002, Medical hypotheses.

Failure of lymphocyte microcytotoxicity to distinguish relapsers from non-relapsers in melanoma patients receiving post-surgical adjuvant chemotherapy.

M. Mastrangelo, R. Bellet, R. Prehn, 1978, European Journal of Cancer.

The immunity-inhibiting role of the spleen and the effect of dosage and route of antigen administration in a homograft reaction.

R. Prehn, 1959, Bulletin de la Societe internationale de chirurgie.

In vitro "spontaneous" neoplastic transformation of mouse fibroblasts in diffusion chambers.

G. Parmiani, R. Prehn, G. Carbone, 1971, Journal of the National Cancer Institute.

The influence of sex on isologous skin grafting in the mouse.

R. Prehn, J. Main, 1956, Journal of the National Cancer Institute.

Destruction of tumor as an "innocent bystander" in an immune response specifically directed against nontumor antigens.

R. Prehn, 1973, Israel journal of medical sciences.

Immune status of autochthonous and adoptively protected mice toward spontaneous and chemically induced tumors.

R. Prehn, M. A. Basombrío, 1972, Cancer research.

Role of immunity in the biology of cancer.

R. Prehn, 1964, Proceedings. National Cancer Conference.

An immune reaction may be necessary for cancer development

R. Prehn, 2006, Theoretical Biology and Medical Modelling.

Tumor inhibitory T cell immunity may be largely a transplantation artifact not necessarily dependent upon a lack of Tregs

N. Graves, R. Prehn, D. Solomon, 2013, Theoretical Biology and Medical Modelling.

Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?

R. Prehn, 2007, Theoretical Biology and Medical Modelling.

Immunostimulation and Immunoinhibition of Premalignant Lesions

R. Prehn, 2007, Theoretical Biology and Medical Modelling.

Summary of the Tumor Antigens Session

R. Prehn, 1972 .

Clinical and immunological significance of human melanoma cytotoxic antibody.

M. Mastrangelo, R. Prehn, A. Bodurtha, 1975, Cancer research.

Attempted induction of tumor antigens in carcinogen-treated cells.

S. Litwin, E. J. Andrews, R. Prehn, 1972, Journal of the National Cancer Institute.

Mobile resistance factor in acquired immunity to homologous tissue transplantation.

R. Prehn, J. Main, 1953, Journal of the National Cancer Institute.

Tumor tissue as a site for interstrain tumor transplantation in mice.

M. Klein, R. Prehn, R. A. Malmgren, 1953, Journal of the National Cancer Institute.

The role of mutation in the new cancer paradigm

R. Prehn, 2005, Cancer Cell International.

Immunologic surveillance at the marcoscopic level: nonselective elimination of premalignant skin papillomas.

R. Prehn, M. Lappé, 1969, Cancer research.

Demonstration of an inverse relationship between regenerative capacity and oncogenesis in the adult frog, Rana pipiens.

R. Custer, R. Prehn, H. Outzen, 1975, Advances in experimental medicine and biology.

Lack of carcinogenic activity of 3-methyl-cholanthrene in the squirrel monkey.

D. Steinmuller, R. Prehn, L. Dillingham, 1969, Journal of the National Cancer Institute.

In Vivo and in Vitro Methylcholanthrene Carcinogenesis in Diffusion Chambers 1

G. Parmiani, R. Prehn, G. Carbone, 1972, Tumori.