Simon Ng

发表

Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06383h

D. Lane, L. Rénia, Y. S. Tan, 2020, Chemical science.

Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality

D. Lane, Y. S. Tan, C. Verma, 2019, bioRxiv.

Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE)

C. Verma, Dilraj Lama, Yen-Chu Lin, 2022, bioRxiv.

De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits.

Nils A. Berglund, D. Lane, C. Verma, 2020, ACS medicinal chemistry letters.

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

Mohan R. Pradhan, D. Lane, J. Hochman, 2019, Molecules.

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

A. Peier, D. Lane, J. Hochman, 2018, Bioorganic & medicinal chemistry.

STUB1 is an intracellular checkpoint for interferon gamma sensing

Chunsheng Zhang, A. Fernandis, Andrey Loboda, 2020, Scientific Reports.

Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

Marian E. Gindy, XiaoNa Wei, Shuhui Lim, 2022, bioRxiv.

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

Nils A. Berglund, D. Lane, C. Verma, 2019, bioRxiv.

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.

A. Peier, C. Strickland, Benjamin J Barlock, 2022, Journal of medicinal chemistry.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

A. Peier, P. Orth, C. Verma, 2021, bioRxiv.

Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States

Shuhui Lim, Y. Juang, Huibin Zhang, 2020, ACS central science.

bioPROTACs establish RAS as a degradable target and provide novel RAS biology insights

Shuhui Lim, Y. Juang, Huibin Zhang, 2020, bioRxiv.

bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

D. Lane, C. Brown, Shuhui Lim, 2020, Proceedings of the National Academy of Sciences.

bioPROTACs as versatile modulators of intracellular therapeutic targets: Application to proliferating cell nuclear antigen (PCNA)

D. Lane, C. Brown, Shuhui Lim, 2019, bioRxiv.

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

A. Peier, D. Lane, J. Hochman, 2018, Bioorganic & medicinal chemistry.

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.

A. Peier, C. Strickland, Benjamin J Barlock, 2021, Journal of medicinal chemistry.

Supporting Information Macrocyclization of an all-D linear α-helical peptide imparts cellular permeability

Yuri, D. Lane, L. Rénia, 2020 .