M. Koutmos

发表

Interplay between substrate recognition, 5′ end tRNA processing and methylation activity of human mitochondrial RNase P

C. Fierke, A. Karasik, M. Koutmos, 2018, bioRxiv.

Interplay between substrate recognition, 5’ end tRNA processing and methylation activity of human mitochondrial RNase P

C. Fierke, A. Karasik, M. Koutmos, 2018 .

A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor

R. Matthews, Supratim Datta, M. Ludwig, 2008, Proceedings of the National Academy of Sciences.

An interprotein Co-S coordination complex in the B12-trafficking pathway.

R. Banerjee, J. Penner‐Hahn, K. Warncke, 2020, Journal of the American Chemical Society.

Synthesis and Characterization of MoFe3S4 and Mo2Fe2S4 Single Cubanes

D. Coucouvanis, M. Koutmos, I. Georgakaki, 2008 .

Dynamics of an [Fe4S4(SPh)4]2- cluster explored via IR, Raman, and nuclear resonance vibrational spectroscopy (NRVS)-analysis using 36S substitution, DFT calculations, and empirical force fields.

D. Case, D. Coucouvanis, Yuming Xiao, 2006, Dalton transactions.

Radical Tropolone Biosynthesis

Alison R. H. Narayan, P. Zimmerman, K. Skinner, 2020 .

Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P

C. Fierke, A. Karasik, M. Koutmos, 2020, RNA.

Disease associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation and tRNA processing by mtRNase P

C. Fierke, A. Karasik, M. Koutmos, 2020, bioRxiv.

Rational Synthesis of High Nuclearity Mo/Fe/S Clusters: The Reductive Coupling Approach in the Convenient Synthesis of (Cl4-cat)2Mo2Fe6S8(PR3)6 [R = Et, nPr, nBu] and the New [(Cl4-cat)2Mo2Fe2S3O(PEt3)3Cl]·1/2(Fe(PEt3)2(MeCN)4) and (Cl4-cat)2Mo2Fe3S5(PEt3)5 Clusters

D. Coucouvanis, M. Koutmos, Jaehong Han, 2001 .

Differential substrate recognition by isozymes of plant protein-only Ribonuclease P

C. Fierke, A. Karasik, M. Koutmos, 2016, RNA.

Mode of inhibition of RNase P by gambogic acid and juglone

C. Fierke, A. Karasik, M. Koutmos, 2022, bioRxiv.

Gambogic acid and juglone inhibit RNase P through distinct mechanisms

C. Fierke, A. Karasik, M. Koutmos, 2022, The Journal of biological chemistry.

Metal clusters as ligands: substitution of Fe ions in Fe/Mo/S clusters by thiophilic Cu(I) ions to give clusters with [Cu4Mo2Fe2S8]4+ and [Cu5Mo3Fe4S11]6+ cores.

D. Coucouvanis, M. Koutmos, 2005, Angewandte Chemie.

The Photoactive Excited State of the B12-Based Photoreceptor CarH.

Nicholas A. Miller, S. Padmanabhan, R. Alonso-Mori, 2020, The journal of physical chemistry. B.

Crystal growth and characterization of zinc–(amino-tris-(methylenephosphonate)) organic–inorganic hybrid networks and their inhibiting effect on metallic corrosion

K. Demadis, M. Koutmos, Stella D. Katarachia, 2005 .

Borohydride anions as terminal ligands on a Fe/Mo/S cluster. Synthesis, structure, and characterization of the [(Cl4-cat)(PPr3)MoFe3S4(BH4)2]2(Bu4N)4 double-fused cubane.

D. Coucouvanis, M. Koutmos, 2004, Inorganic chemistry.

Borohydride, azide, and chloride anions as terminal ligands on Fe/Mo/S clusters. Synthesis, structure and characterization of [(Cl4-cat)(PPr3) MoFe3S4(X)2]2(Bu4N)4 and [(Cl4-cat)(PPr3)MoFe3S4 (PPr3)(X)]2(Bu4N)2 (X = N3-, BH4-, Cl-) double-fused cubanes. NMR reactivity studies of [(Cl4-cat)(PPr3) MoF

D. Coucouvanis, M. Koutmos, I. Georgakaki, 2006, Inorganic chemistry.

Metal clusters as ligands. Substitution of fe ions in Fe/Mo/S clusters by thiophilic CuI ions.

D. Coucouvanis, M. Koutmos, 2006, Inorganic chemistry.

Systematic synthesis of heterometallic Ni/Fe/S and Cu/Fe/S clusters with a pentlandite-like M8S6 core.

D. Coucouvanis, Y. Sanakis, H. Kalyvas, 2005, Journal of the American Chemical Society.

Normal-mode analysis of FeCl4- and Fe2S2Cl42- via vibrational mössbauer, resonance Raman, and FT-IR spectroscopies.

D. Coucouvanis, Yuming Xiao, S. George, 2005, Inorganic chemistry.

Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase.

J. Brynda, M. Kožíšek, M. Buděšínský, 2009, Journal of medicinal chemistry.

Cobalamin-dependent and cobamide-dependent methyltransferases.

R. Matthews, Supratim Datta, Rowena G Matthews, 2008, Current opinion in structural biology.

Specific potassium ion interactions facilitate homocysteine binding to betaine‐homocysteine S‐methyltransferase

P. Jungwirth, Kazuhiro Yamada, T. Garrow, 2014, Proteins.

Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5' End Processing Enzymes.

C. Fierke, A. Karasik, M. Koutmos, 2016, Journal of molecular biology.

Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase.

Alison R. H. Narayan, Joshua B Pyser, L. Mallik, 2020, ACS chemical biology.

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine β-synthase

R. Banerjee, Janet L. Smith, O. Kabil, 2010, Proceedings of the National Academy of Sciences.

Betaine-Homocysteine S-Methyltransferase-2 Is an S-Methylmethionine-Homocysteine Methyltransferase*

T. Garrow, M. Koutmos, S. Szegedi, 2008, Journal of Biological Chemistry.

Insights into the reactivation of cobalamin-dependent methionine synthase

R. Matthews, Janet L. Smith, Supratim Datta, 2009, Proceedings of the National Academy of Sciences.

Coordination chemistry controls the thiol oxidase activity of the B12-trafficking protein CblC

Nicholas A. Lesniak, B. Kräutler, R. Banerjee, 2017, The Journal of Biological Chemistry.

RNase P enzymes

D. Engelke, C. Fierke, M. Koutmos, 2013, RNA biology.

Divergent scaffolds for a conserved biological reaction

D. Engelke, C. Fierke, M. Koutmos, 2013 .

Autoinhibition and Signaling by the Switch II Motif in the G-protein Chaperone of a Radical B12 Enzyme*

R. Banerjee, M. Koutmos, Michael Lofgren, 2013, The Journal of Biological Chemistry.

Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes

A. Roca, L. Schook, Y. Ishida, 2015, PloS one.

5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity

Kazuhiro Yamada, M. Koutmos, J. Mendoza, 2022, The Journal of biological chemistry.

The folate-binding module of Thermus thermophilus cobalamin-dependent methionine synthase displays a distinct variation of the classical TIM barrel: a TIM barrel with a `twist'.

Kazuhiro Yamada, M. Koutmos, 2018, Acta crystallographica. Section D, Structural biology.

Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair

V. Mootha, Hongying Shen, R. Banerjee, 2019, Science.

Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases*

R. Banerjee, Kazuhiro Yamada, C. Gherasim, 2015, The Journal of Biological Chemistry.

Splicing variants of the porcine betaine-homocysteine S-methyltransferase gene: implications for mammalian metabolism.

L. Schook, R. Ganu, L. Rund, 2013, Gene.

Superclusters: a host-guest complex with a cyclic array of three bridged MoFe3S4 clusters.

D. Coucouvanis, M. Koutmos, 2004, Angewandte Chemie.

A Switch III Motif Relays Signaling between a B12 Enzyme and its G-protein Chaperone†

R. Banerjee, D. Padovani, M. Koutmos, 2013, Nature chemical biology.

Metal active site elasticity linked to activation of homocysteine in methionine synthases

R. Matthews, Janet L. Smith, R. Pejchal, 2008, Proceedings of the National Academy of Sciences.

Antivitamins B12: Synthesis and application as inhibitory ligand of the B12-tailoring enzyme CblC.

B. Kräutler, M. Koutmos, M. Ruetz, 2022, Methods in enzymology.

Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions

R. Banerjee, Shubhadra Pillay, M. Koutmos, 2021, The Journal of biological chemistry.

Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B12

R. Banerjee, M. Koutmos, M. Ruetz, 2020, Proceedings of the National Academy of Sciences.

Structural Basis of Multifunctionality in a Vitamin B12-processing Enzyme*

R. Banerjee, Janet L. Smith, C. Gherasim, 2011, The Journal of Biological Chemistry.

Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase*

R. Banerjee, Kazuhiro Yamada, P. Yadav, 2013, The Journal of Biological Chemistry.

COBALAMIN- AND COBAMIDE-DEPENDENT METHYLTRANSFERASES

R. Matthews, Supratim Datta, M. Koutmos, 2009 .

Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate.

B. Kräutler, R. Banerjee, K. Wurst, 2017, Angewandte Chemie.

Kinetic mechanism of human mitochondrial RNase P

C. Fierke, M. Koutmos, Xin Liu, 2019, bioRxiv.

Loss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila

R. T. Cox, A. Karasik, M. Koutmos, 2016, Nucleic acids research.

Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo

Kazuhiro Yamada, M. Koutmos, J. Mendoza, 2023, bioRxiv.

Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5′ processing

C. Fierke, M. Koutmos, Michael J Howard, 2012, Proceedings of the National Academy of Sciences.

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine β-synthase (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 49 (20958-20963) DOI: 10.1073/pnas.1011448107)

R. Banerjee, Janet L. Smith, O. Kabil, 2011 .

A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P.

C. Fierke, N. Walter, D. Rueda, 2010, Journal of molecular biology.

Bacterial RNA-free RNase P: structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P.

M. Koutmos, J. Mendoza, Anna G. Anders, 2023, The Journal of biological chemistry.

Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases*

R. Banerjee, Kazuhiro Yamada, C. Gherasim, 2015, The Journal of Biological Chemistry.

Insights into the reactivation of cobalamin-dependent methionine synthase

R. Matthews, Janet L. Smith, Supratim Datta, 2009, Proceedings of the National Academy of Sciences.

Structural basis of S-adenosylmethionine-dependent Allosteric Transition from Active to Inactive States in Methylenetetrahydrofolate Reductase

M. Koutmos, J. Mendoza, Kazuhiro Yamada, 2023, bioRxiv.

Pseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures

Mehmet Tardu, L. Mallik, M. Koutmos, 2022, Proceedings of the National Academy of Sciences.

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

Nupur K. Das, J. Mancias, M. Koutmos, 2024, bioRxiv.

Selenoproteins and tRNA-Sec: regulators of cancer redox homeostasis.

M. Koutmos, Balázs Győrffy, Stephen L. DeAngelo, 2023, Trends in cancer.

Collision-Induced Unfolding Reveals Disease-Associated Stability Shifts in Mitochondrial Transfer Ribonucleic Acids.

B. Ruotolo, M. Koutmos, Varun V. Gadkari, 2024, Journal of the American Chemical Society.

Fluorescent Ligand Equilibrium Displacement: A High-Throughput Method for Identification of FMN Riboswitch-Binding Small Molecules

M. Koutmos, Suada Leskaj, Elizabeth D Tidwell, 2024, International journal of molecular sciences.