A. Gille

发表

Role of HCA₂ (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin.

S. Offermanns, J. Hanson, A. Gille, 2012, Pharmacology & therapeutics.

GPR 109 A ( PUMA-G / HM 74 A ) mediates nicotinic acid – induced flushing

Z. Benyó, K. Pfeffer, S. Offermanns, 2005 .

GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.

Z. Benyó, K. Pfeffer, S. Offermanns, 2005, The Journal of clinical investigation.

Nicotinic Acid-Induced Flushing Is Mediated by Activation of Epidermal Langerhans Cells

Clare L. Bennett, Z. Benyó, S. Offermanns, 2006, Molecular Pharmacology.

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.

S. Tunaru, A. Wirth, S. Offermanns, 2010, The Journal of clinical investigation.

Infusion of Reconstituted High-Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial

C. Shear, J. Alexander, D. Angiolillo, 2015, Journal of the American Heart Association.

Pharmacokinetics and Safety of CSL112 (Apolipoprotein A‐I [Human]) in Adults With Moderate Renal Impairment and Normal Renal Function

S. Wright, M. Tortorici, A. Gille, 2018, Clinical pharmacology in drug development.

Coproduction of EPA and Fucoxanthin withP. tricornutum– A Promising Approach for Up‐ and Downstream Processing

U. Schmid-Staiger, T. Hirth, Jan Müller, 2020, Chemie Ingenieur Technik.

Microalgae as a potential source of carotenoids: Comparative results of an in vitro digestion method and a feeding experiment with C57BL/6J mice

S. Bischoff, K. Briviba, S. Louis, 2018, Journal of Functional Foods.

Moderate Renal Impairment Does Not Impact the Ability of CSL112 (Apolipoprotein A‐I [Human]) to Enhance Cholesterol Efflux Capacity

L. Deckelbaum, S. Wright, M. Tortorici, 2018, Journal of clinical pharmacology.

Reconstituted high‐density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component

D. Rader, E. Herzog, S. Wright, 2016, Journal of applied toxicology : JAT.

A multiple ascending dose study of CSL112, an infused formulation of ApoA‐I

C. Shear, S. Wright, R. Easton, 2014, Journal of clinical pharmacology.

Anti-inflammatory effects of Phaeodactylum tricornutum extracts on human blood mononuclear cells and murine macrophages

S. Bischoff, U. Schmid-Staiger, K. Briviba, 2018, Journal of Applied Phycology.

Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5′-triphosphates, nucleoside 5′-[γ-thio]triphosphates and nucleoside 5′-[β,γ-imido]triphosphates

R. Seifert, T. Mou, G. Lushington, 2005 .

CSL112 (Apolipoprotein A-I [Human]) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease Patients

S. Wright, M. Tortorici, G. Hartel, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs.

S. Sprang, R. Seifert, Cibele S. Pinto, 2009, Biochemical pharmacology.

Pharmacometric analyses to characterize the effect of CSL112 on apolipoprotein A‐I and cholesterol efflux capacity in acute myocardial infarction patients

P. Tricoci, S. Wright, M. Tortorici, 2020, British journal of clinical pharmacology.

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

T. Schwartz, M. K. Nøhr, S. Offermanns, 2015, Neuroscience.

CSL112 (Apolipoprotein A-I [Human]) Strongly Enhances Plasma Apoa-I and Cholesterol Efflux Capacity in Post-Acute Myocardial Infarction Patients: A PK/PD Substudy of the AEGIS-I Trial

L. Deckelbaum, C. Gibson, S. Wright, 2022, Journal of cardiovascular pharmacology and therapeutics.

Ca2+ signalling of kinins in cells expressing rat, mouse and human B1/B2-receptor.

A. Gille, A. Faussner, Radka Zubakova, 2008, International Immunopharmacology.

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.

S. Tunaru, S. Offermanns, Cong Tang, 2010, Cell metabolism.

Nicotinic acid: pharmacological effects and mechanisms of action.

S. Offermanns, Kashan Ahmed, E. Bodor, 2008, Annual review of pharmacology and toxicology.

Characterization of Mouse Heart Adenylyl Cyclase

R. Seifert, B. König, A. Gille, 2009, Journal of Pharmacology and Experimental Therapeutics.

Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2′(3′)-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides

R. Seifert, Wei-Jen Tang, Yuequan Shen, 2009, Molecular Pharmacology.

Broad Specificity of Mammalian Adenylyl Cyclase for Interaction with 2′,3′-Substituted Purine- and Pyrimidine Nucleotide Inhibitors

Roland Seifert, Andreas Gille, S. Sprang, 2006, Molecular Pharmacology.

Structural Basis for the Inhibition of Mammalian Membrane Adenylyl Cyclase by 2 ′(3′)-O-(N-Methylanthraniloyl)-guanosine 5 ′-Triphosphate*

Roland Seifert, Andreas Gille, S. Sprang, 2005, Journal of Biological Chemistry.

Pressurized extraction of unsaturated fatty acids and carotenoids from wet Chlorella vulgaris and Phaeodactylum tricornutum biomass using subcritical liquids

U. Schmid-Staiger, T. Hirth, U. Schliessmann, 2018, GCB Bioenergy.

Bioaccessibility of carotenoids from Chlorella vulgaris and Chlamydomonas reinhardtii

C. Posten, K. Briviba, A. Gille, 2016, International journal of food sciences and nutrition.

Novel Formulation of a Reconstituted High-Density Lipoprotein (CSL112) Dramatically Enhances ABCA1-Dependent Cholesterol Efflux

A. Leis, S. Wright, I. Pragst, 2013, Arteriosclerosis, thrombosis, and vascular biology.

A method for detection of anti-drug antibodies to a biotherapeutic (CSL112) with endogenous counterpart (apolipoprotein A-I) using a novel sample pre-treatment electrochemiluminescence assay.

B. Kingwell, E. Velkoska, A. Gille, 2022, Journal of immunological methods.

GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.

T. Schwartz, M. S. Engelstoft, K. V. Grunddal, 2013, Endocrinology.

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Maja A. Puchades, J. Storm-Mathisen, U. Wisløff, 2017, Nature Communications.

Co-expression of the beta2-adrenoceptor and dopamine D1-receptor with Gsalpha proteins in Sf9 insect cells: limitations in comparison with fusion proteins.

R. Seifert, A. Gille, 2003, Biochimica et biophysica acta.

Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice

S. Bischoff, U. Schmid-Staiger, K. Briviba, 2018, Nutrients.

Inhibitors of membranous adenylyl cyclases.

Roland Seifert, Andreas Gille, Gerald H Lushington, 2012, Trends in pharmacological sciences.

A Lipophilic Fucoxanthin-Rich Phaeodactylum tricornutum Extract Ameliorates Effects of Diet-Induced Obesity in C57BL/6J Mice

C. Posten, A. Palou, M. Bonet, 2019, Nutrients.

Abstracts from the 10th C1-inhibitor deficiency workshop

William H. Yang, A. Szilágyi, M. Margaglione, 2017, Allergy, Asthma & Clinical Immunology.

Anti-inflammatory effects of Phaeodactylum tricornutum extracts on human blood mononuclear cells and murine macrophages

S. Bischoff, U. Schmid-Staiger, K. Briviba, 2018, Journal of Applied Phycology.

Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2′,3′-O-(2,4,6-Trinitrophenyl)-Substituted Nucleoside 5′-Triphosphates

S. Sprang, R. Seifert, T. Mou, 2009, Journal of Pharmacology and Experimental Therapeutics.

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells.

S. Offermanns, J. Kero, A. Gille, 2011, The Journal of clinical investigation.

Effect of sonication on bioaccessibility and cellular uptake of carotenoids from preparations of photoautotrophic Phaeodactylum tricornutum.

C. Posten, K. Briviba, A. Gille, 2017, Food research international.

Lipophilic compounds, but not fucoxanthin, mediate the genotoxic effect of photoautotrophic grown Phaeodactylum tricornutum in Caco-2 and HT-29 cells

C. Posten, S. Bischoff, K. Briviba, 2020, Journal of Functional Foods.

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

Stefan Offermanns, Andreas Gille, Hermann-Josef Gröne, 2015, Nature Medicine.

Xanthine nucleotide-specific G-protein α-subunits: a novel approach for the analysis of G-protein-mediated signal transduction

R. Seifert, A. Gille, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112

S. Wright, P. Schuetz, A. Kontush, 2016, Circulation research.

CSL112 Enhances Biomarkers of Reverse Cholesterol Transport After Single and Multiple Infusions in Healthy Subjects

C. Shear, S. Wright, R. Easton, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Photoautotrophically grown Chlorella vulgaris show genotoxic potential but no apoptotic effect in epithelial cells.

C. Posten, S. Bischoff, K. Briviba, 2019, Journal of agricultural and food chemistry.

Differential Inhibition of Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by Purine and Pyrimidine Nucleotides*

R. Seifert, T. Mou, G. Lushington, 2004, Journal of Biological Chemistry.

Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases.

S. Sprang, R. Seifert, Cibele S. Pinto, 2011, Biochemical pharmacology.

Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2′,3′-O-(N-Methylanthraniloyl)-Inosine 5′-Triphosphate

S. Sprang, A. Dixit, R. Seifert, 2011, Molecular Pharmacology.

2′(3′)-O-(N-Methylanthraniloyl)-substituted GTP Analogs: A Novel Class of Potent Competitive Adenylyl Cyclase Inhibitors*

R. Seifert, A. Gille, 2003, The Journal of Biological Chemistry.

MANT-substituted guanine nucleotides: a novel class of potent adenylyl cyclase inhibitors.

R. Seifert, A. Gille, 2003, Life sciences.

GDP Affinity and Order State of the Catalytic Site Are Critical for Function of Xanthine Nucleotide-selective GαsProteins*

R. Seifert, A. Gille, M. Doughty, 2003, The Journal of Biological Chemistry.

Distinct Interactions of GTP, UTP, and CTP with GsProteins*

S. Sprang, Hui-yu Liu, R. Seifert, 2002, The Journal of Biological Chemistry.

Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate

Dimitrios Tsitsipatis, H. Steinbrenner, L. Klotz, 2018, Redox biology.

Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2′,3′-O-(2,4,6-Trinitrophenyl)-Substituted Nucleoside 5′-Triphosphates

S. Sprang, R. Seifert, T. Mou, 2009, Journal of Pharmacology and Experimental Therapeutics.

Low-affinity interactions of BODIPY-FL-GTPγS and BODIPY-FL-GppNHp with Gi- and Gs-proteins

R. Seifert, A. Gille, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.