Junying Wang

发表

Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.

Kenneth K. Wu, Q. Deng, Hong C Shen, 2007, Bioorganic & medicinal chemistry letters.

Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.

M. Forrest, Kenneth K. Wu, Q. Deng, 2007, Journal of medicinal chemistry.

Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.

M. Forrest, Kenneth K. Wu, Q. Deng, 2010, Journal of medicinal chemistry.

Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.

L. Shearman, Richard Z. Chen, R. Ball, 2010, Journal of medicinal chemistry.

Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.

Hong C Shen, X. Tong, Qing Chen, 2010, Bioorganic & medicinal chemistry letters.

Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.

D. Macneil, J. Metzger, D. Macintyre, 2008, European journal of pharmacology.

Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor.

A. Frassetto, Richard Z. Chen, T. Fong, 2008, European journal of pharmacology.

Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents

D. Macintyre, L. V. D. van der Ploeg, L. Shearman, 2007, Journal of Pharmacology and Experimental Therapeutics.

Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.

J. Chen, L. V. D. van der Ploeg, L. Shearman, 2007, Bioorganic & medicinal chemistry letters.

Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.

L. Shearman, D. Marsh, Sanjeev Kumar, 2010, Bioorganic & medicinal chemistry letters.

Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.

L. Shearman, T. Fong, X. Tong, 2009, Bioorganic & medicinal chemistry letters.

Discovery of MK‐8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption

Q. Dang, Jing Li, P. Coleman, 2015, ChemMedChem.

Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists.

J. Chen, L. V. D. van der Ploeg, L. Shearman, 2005, Bioorganic & medicinal chemistry letters.

Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4.

P. Davies, M. Maccoss, C. Raab, 2009, Journal of medicinal chemistry.

Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.

L. Shearman, M. Goulet, T. Fong, 2010, Bioorganic & medicinal chemistry letters.

Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.

L. V. D. van der Ploeg, L. Shearman, D. Marsh, 2006, Journal of medicinal chemistry.

Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists.

J. Chen, L. V. D. van der Ploeg, L. Shearman, 2005, Bioorganic & medicinal chemistry letters.

Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists.

D. Macintyre, L. V. D. van der Ploeg, L. Shearman, 2006, Bioorganic & medicinal chemistry letters.

Yue Feng, Donald J. Marsh, Hongbo Qi, 2006, Journal of medicinal chemistry.

Simple and sensitive liquid chromatography/tandem mass spectrometry method for the determination of diazepam and its major metabolites in rat cerebrospinal fluid.

J. Fenyk-Melody, X. Tong, J. Pivnichny, 2003, Rapid communications in mass spectrometry : RCM.

2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists.

Ramon Camacho, D. Macneil, R. DeVita, 2006, Bioorganic & medicinal chemistry letters.

Effect of signal interference from dosing excipients on pharmacokinetic screening of drug candidates by liquid chromatography/mass spectrometry.

Patrick R Griffin, P. Griffin, J. Fenyk-Melody, 2002, Analytical chemistry.

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.

Donald F Thompson, L. Shearman, A. Frassetto, 2009, Journal of medicinal chemistry.

Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.

H. Burns, R. Hargreaves, W. Hagmann, 2007, Journal of medicinal chemistry.

Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists.

M. Maccoss, W. Hagmann, K. Lyons, 2002, Bioorganic & medicinal chemistry letters.

Molecular modeling aided design of nicotinic acid receptor GPR109A agonists.

Ning Ren, Q. Deng, Steven L Colletti, 2008, Bioorganic & medicinal chemistry letters.

High-throughput pharmacokinetics screen of VLA-4 antagonists by LC/MS/MS coupled with automated solid-phase extraction sample preparation.

X. Tong, J. Pivnichny, James V Pivnichny, 2004, Journal of pharmaceutical and biomedical analysis.

Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

Q. Dang, P. Coleman, A. Templeton, 2014, Pharmaceuticals.

Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists.

D. Macintyre, L. V. D. van der Ploeg, L. Shearman, 2007, Bioorganic & medicinal chemistry letters.

Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.

Hong C Shen, X. Tong, Qing Chen, 2010, Bioorganic & medicinal chemistry letters.