M. Hammond

发表

Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.

Kenneth K. Wu, Q. Deng, Hong C Shen, 2007, Bioorganic & medicinal chemistry letters.

Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.

M. Forrest, Kenneth K. Wu, Q. Deng, 2007, Journal of medicinal chemistry.

Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A.

Hong C Shen, J. Tata, S. Colletti, 2008, Bioorganic & medicinal chemistry letters.

Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists.

Hong C Shen, J. Tata, S. Colletti, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.

Kenneth K. Wu, Q. Deng, Hong C Shen, 2009, Journal of medicinal chemistry.

Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.

M. Forrest, Kenneth K. Wu, Q. Deng, 2010, Journal of medicinal chemistry.

(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.

D. Connolly, J. Knudsen, C. Sage, 2012, Journal of medicinal chemistry.

2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy.

S. Wright, S. Eveland, S. A. Hyland, 2011, Bioorganic & medicinal chemistry letters.

Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.

J. Schaeffer, Wei Tang, S. Rohrer, 2004, Bioorganic & medicinal chemistry letters.

Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.

J. Schaeffer, Wei Tang, S. Rohrer, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of platensimycin analogs.

M. Maccoss, Hong C Shen, S. Soisson, 2009, Bioorganic & medicinal chemistry letters.

Chapter 13. Recent Advances in Anti-Infective Agents

M. Hammond, 1993 .

Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands--modeling and binding data don't agree!

R. Mosley, E. Birzin, M. Hammond, 2004, Bioorganic & medicinal chemistry letters.

Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs.

J. Schaeffer, S. Rohrer, E. Birzin, 2004, Bioorganic & medicinal chemistry letters.

2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).

R. Mosley, S. Rohrer, E. Birzin, 2003, Bioorganic & medicinal chemistry letters.

Agonist-like SERM effects on ERα-mediated repression of MMP1 promoter activity predict in vivo effects on bone and uterus

D. Kimmel, G. Rodan, D. Towler, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.

Hong C Shen, X. Tong, Qing Chen, 2010, Bioorganic & medicinal chemistry letters.

Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat.

Amjad Ali, M. Forrest, G. Harris, 2008, Bioorganic & medicinal chemistry.

The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.

H. Wilkinson, N. Sharma, M. Carlquist, 2006, Bioorganic & medicinal chemistry letters.

Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.

H. Wilkinson, D. Kimmel, L. Freedman, 2005, Bioorganic & medicinal chemistry letters.

Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains.

J. Schaeffer, S. Rohrer, E. Birzin, 2004, Bioorganic & medicinal chemistry letters.

Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.

D. Zaller, Amjad Ali, Douglas K. Miller, 2004, Journal of medicinal chemistry.

Antibacterial activity of G6-quaternary ammonium derivatives of a lipophilic vancomycin analogue.

K. Chapman, R. Kilburn, M. Hammond, 2002, Bioorganic & medicinal chemistry letters.

The mass spectra of suprasterol3-II, vitamin D3 and related molecules

H. Jacobs, W. Okamura, J. V. Thuijl, 1976 .

THE CHEMISTRY AND CONFORMATIONAL AND BIOLOGICAL ANALYSIS OF VITAMIN D3, ITS METABOLITES AND ANALOGUES

A. Norman, W. Okamura, R. M. Wing, 1976, Clinical endocrinology.

The fungal cell wall as a drug discovery target: SAR of novel echinocandin analogs

J. Balkovec, J. Dropinski, R. Black, 1997 .

Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.

D. Zaller, Amjad Ali, Douglas K. Miller, 2005, Bioorganic & Medicinal Chemistry Letters.

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin

D. Schmatz, J. Balkovec, K. Bartizal, 1992, Antimicrobial Agents and Chemotherapy.

Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B0 derivatives

R. Zambias, J. Balkovec, K. Bartizal, 1995 .

Synthesis and activity of 2-(sulfonamido)methyl-carbapenems: discovery of a novel, anti-MRSA 1,8-naphthosultam pharmacophore.

J. Heck, R. Wilkening, K. J. Wildonger, 1999, Bioorganic & medicinal chemistry letters.

Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP).

R. Schwartz, J. Heck, R. Zambias, 1992, Journal of medicinal chemistry.

The inhibition of C5a receptor binding by analogs of L-156,602, a cyclic hexadepsipeptide antibiotic

Sumire V. Kobayashi, W. Hagmann, J. Boger, 1992 .

Antagonist-induced, activation function-2-independent estrogen receptor α phosphorylation

G. Rodan, Nan Wei, L. Freedman, 2006 .

Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives

R. Zambias, J. Balkovec, K. Bartizal, 1994 .

Synthesis and antifungal activity of novel cationic pneumocandin B(o) derivatives.

R. Zambias, J. Balkovec, K. Bartizal, 1994, Journal of Medicinal Chemistry.

Studies on vitamin D (calciferol) and its analogs. 18. The vinylallene approach to the 1-hydroxyvitamin D system. New sigmatropic reactions in the vitamin D series

W. Okamura, A. Mouriño, M. Hammond, 1980 .

6H-Benzo[c]chromen-6-one derivatives as selective ERβ agonists

R. Mosley, L. Locco, S. Rohrer, 2006 .

2-Arylbenzoxazoles as CETP inhibitors: substitution and modification of the alpha-alkoxyamide moiety.

S. Wright, S. Eveland, S. A. Hyland, 2010, Bioorganic & medicinal chemistry letters.

Dicationic 2-fluorenonylcarbapenems: potent anti-MRS agents with improved solubility and pharmacokinetic properties.

M. Greenlee, M. Hammond, J. Huber, 1999, Bioorganic & medicinal chemistry letters.

Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic.

H. Rosen, J. Heck, J. Kozarich, 1999, Science.

Succinic Acids as Potent Inhibitors of Plasmid-borne IMP-1 Metallo-β-lactamase*

N. Sharma, P. Fitzgerald, S. Olson, 2001, The Journal of Biological Chemistry.

6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists.

R. Mosley, L. Locco, S. Rohrer, 2006, Bioorganic & medicinal chemistry letters.

Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.

J. Schaeffer, R. Mosley, S. Rohrer, 2004, Bioorganic & medicinal chemistry letters.

Bridged androstenediol analogs as ER-β selective SERMs

M. Mojena, S. Rohrer, E. Birzin, 2007 .

Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands.

R. Mosley, S. Rohrer, E. Birzin, 2006, Bioorganic & medicinal chemistry letters.

Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists.

S. Nilsson, A. Thorsell, L. Colwell, 2006, Bioorganic & medicinal chemistry letters.

6H-Benzo[c]chromen-6-one Derivatives as Selective ERβ Agonists.

R. Mosley, L. Locco, S. Rohrer, 2006 .

Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans.

J. Schaeffer, R. Mosley, Jian Liu, 2005, Bioorganic & medicinal chemistry letters.

Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem.

J. Hermes, N. Sharma, P. Fitzgerald, 2010, Bioorganic & medicinal chemistry letters.

Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib.

Amjad Ali, S. Wright, Hong Li, 2011, Journal of medicinal chemistry.

Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein.

Amjad Ali, S. Wright, Zhijian Lu, 2011, ACS medicinal chemistry letters.

Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.

Ying Li, N. Sharma, P. Fitzgerald, 2005, Bioorganic & medicinal chemistry letters.

Estrogen receptor beta-subtype selective tetrahydrofluorenones: use of a fused pyrazole as a phenol bioisostere.

S. Nilsson, A. Thorsell, L. Colwell, 2006, Bioorganic & medicinal chemistry letters.

Total synthesis of 1-156,602, a novel cyclic hexadepsipeptide antibiotic

F. Baker, J. Boger, S. Bondy, 1990 .

Selective transamination and optical induction by a .beta.-cyclodextrin-pyridoxamine artificial enzyme

R. Breslow, M. Lauer, M. Hammond, 1980 .

Estrogen receptor ligands. 12. Synthesis of the major metabolites of an ERalpha-selective, dihydrobenzoxathiin antagonist for osteoporosis.

Wei Tang, G. Doss, Zhoupeng Zhang, 2005, Organic letters.

A convenient synthesis of 4-tert-butyl-5-benzofuranols and dihydrobenzofuranols

R. Zambias, C. G. Caldwell, M. Hammond, 1988 .

Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin.

B. Nare, F. Vicente, D. Wisniewski, 2015, Chemistry & biology.

Sigmatropic rearrangement of vinylallenes: a novel route to the 1-hydroxyvitamin D system

W. Okamura, A. Mouriño, M. Hammond, 1978 .

Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: discovery of L-786,392.

J. Heck, S. T. Waddell, R. Wilkening, 1999, Bioorganic & medicinal chemistry letters.

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®.

J. Hermes, G. Scapin, N. Sharma, 2014, Bioorganic & medicinal chemistry letters.

Antibiotic use in the Australian community, 1990‐1995

J. Primrose, A. Mant, S. Whicker, 1997, The Medical journal of Australia.

Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.

D. Zaller, Amjad Ali, Douglas K. Miller, 2007, Bioorganic & medicinal chemistry letters.

The Synthesis of 5-Hydroxy-2,3-dihydrobenzo(B)thiophene (1) via an Efficient One Step Preparation of 5-Nitro-Benzo(B)thiophene-2-carboxylate(3A)

R. Zambias, M. Hammond, 1991 .

2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice.

Amjad Ali, S. Wright, Dooseop Kim, 2011, Bioorganic & medicinal chemistry letters.

Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712.

J. Hermes, G. Scapin, N. Sharma, 2011, Bioorganic & medicinal chemistry letters.

Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs.

J. Schaeffer, L. Colwell, S. Rohrer, 2004, Bioorganic & medicinal chemistry letters.

Androstenediol analogs as ER-β-selective SERMs

N. Sharma, P. Fitzgerald, R. Mosley, 2006 .

Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.

Scott K. Smith, D. Zaller, Amjad Ali, 2005, Bioorganic & Medicinal Chemistry Letters.

2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety.

Amjad Ali, S. Wright, S. Eveland, 2010, Bioorganic & medicinal chemistry letters.

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.

T. Baillie, Wei Tang, G. Doss, 2002, Chemical research in toxicology.

Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase

David L. Pompliano, James M. Balkovec, D. Pompliano, 1999 .

Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.

G. Rodan, Nan Wei, L. Freedman, 2006, Molecular endocrinology.

Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha.

Bryan Kraker, P. Fitzgerald, J. Schaeffer, 2007, Bioorganic & medicinal chemistry letters.

SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.

Amjad Ali, S. Wright, Q. Deng, 2012, Bioorganic & medicinal chemistry letters.

Design of a novel class of biphenyl CETP inhibitors.

A. Theberge, Amjad Ali, S. Wright, 2010, Bioorganic & medicinal chemistry letters.

Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.

Ann-Gerd Thorsell, N. Sharma, P. Fitzgerald, 2004, Journal of medicinal chemistry.

Ertapenem: a Group 1 carbapenem with distinct antibacterial and pharmacological properties.

M. Hammond, 2004, The Journal of antimicrobial chemotherapy.

In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa

D. Wisniewski, M. Motyl, N. Murgolo, 2019, BMC Microbiology.

Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives.

D. Schmatz, R. Zambias, J. Balkovec, 1994 .

Preparation and structure-activity relationships of simplified analogues of the antifungal agent cilofungin: a total synthesis approach.

D. Schmatz, J. Heck, R. Zambias, 1992, Journal of medicinal chemistry.

Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins.

J. Schaeffer, S. Rohrer, E. Birzin, 2004, Bioorganic & medicinal chemistry letters.

Pneumocandin Bo acid degradate

B. Arison, M. Hammond, F. A. Bouffard, 1995 .

STUDIES ON VITAMIN D (CALCIFEROL) AND ITS ANALOGS. 12. STRUCTURAL AND SYNTHETIC STUDIES OF 5,6-TRANS-VITAMIN D3 AND THE STEREOISOMERS OF 10,19-DIHYDROVITAMIN D3 INCLUDING DIHYDROTACHYSTEROL3

A. Norman, W. Okamura, R. M. Wing, 1977 .

Studies on vitamin D (calciferol) and its analogues. 12. Structural and synthetic studies of 5,6-trans-vitamin D3 and the stereoisomers of 10,19-dihydrovitamin D3 including dihydrotachysterol3.

A. Norman, W. Okamura, R. M. Wing, 1977, The Journal of organic chemistry.

Sclerema neonatorum.

M. Hammond, W. E. Hughes, 1948, The Journal of pediatrics.

Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain.

J. Schaeffer, S. Rohrer, E. Birzin, 2005, Bioorganic & Medicinal Chemistry Letters.

Androstene-3,5-dienes as ER-β selective SERMs

R. Mosley, M. Mojena, S. Rohrer, 2007 .

Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.

R. Mosley, S. Rohrer, E. Birzin, 2005, Bioorganic & medicinal chemistry letters.

Biochemical and biological activities of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol (L-651,896), a novel topical anti-inflammatory agent.

R. Egan, E. Opas, N. Jensen, 1987, Biochemical pharmacology.

2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis.

F. Baker, D. Macintyre, J. Boger, 1989, Journal of medicinal chemistry.