Michael S Wolff

发表

Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.

M. Forrest, Kenneth K. Wu, Q. Deng, 2007, Journal of medicinal chemistry.

Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists.

Hong C Shen, J. Tata, S. Colletti, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.

Kenneth K. Wu, Q. Deng, Hong C Shen, 2009, Journal of medicinal chemistry.

Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia.

D. Blom, J. Tata, S. Colletti, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.

M. Forrest, Kenneth K. Wu, Q. Deng, 2010, Journal of medicinal chemistry.

GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.

J. Tata, S. Colletti, E. Carballo-Jane, 2010, Bioorganic & medicinal chemistry letters.

Anthranilic acid replacements in a niacin receptor agonist.

D. Blom, Hong C Shen, J. Tata, 2010, Bioorganic & medicinal chemistry letters.

The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties.

J. Tata, S. Colletti, J. Imbriglio, 2011, Bioorganic & medicinal chemistry letters.

1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

J. Demartino, E. Sherer, P. Váchal, 2012, Journal of medicinal chemistry.

Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.

M. Forrest, M. E. Mccann, J. Tata, 2007, Journal of pharmacological and toxicological methods.

Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis[S]

J. Chen, G. O'neill, Sheng-ping Wang, 2013, Journal of Lipid Research.

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

M. Reitman, D. Macneil, R. Berger, 2008, Bioorganic & medicinal chemistry letters.

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.

Shirly Pinto, J. Lisnock, R. DeVita, 2013, ACS medicinal chemistry letters.

Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.

Shirly Pinto, M. Reibarkh, R. DeVita, 2019, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.

Shirly Pinto, J. Lisnock, R. DeVita, 2014, ACS medicinal chemistry letters.

Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.

Jeffrey T. Kuethe, J. Demartino, E. Sherer, 2016, Journal of medicinal chemistry.

Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).

Shirly Pinto, R. Nargund, P. Váchal, 2019, Bioorganic & medicinal chemistry letters.

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia[S]

N. Geoghagen, L. Mitnaul, Peggy H. Wong, 2012, Journal of Lipid Research.

2-(2-pyridyl-)ethyl esters A new carboxyl protecting group in peptide synthesis

H. Kessler, Michael S Wolff, H. Kogler, 1984 .

Discovery of imidazole carboxamides as potent and selective CCK1R agonists.

M. Reitman, D. Macneil, S. Qian, 2008, Bioorganic & medicinal chemistry letters.

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia[S]

N. Geoghagen, L. Mitnaul, Peggy H. Wong, 2012, Journal of Lipid Research.

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

M. Reitman, D. Macneil, R. Berger, 2008, Bioorganic & medicinal chemistry letters.

1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

E. Sherer, K. Chapman, M. Wyvratt, 2012, Journal of medicinal chemistry.