J. Pinto

发表

Familial Dilated Cardiomyopathy Associated With a Novel Combination of Compound Heterozygous TNNC1 Variants

Emily K. Mis, W. Ji, P. Chase, 2020, Frontiers in Physiology.

Cardiac Troponin Mutations and Restrictive Cardiomyopathy

J. Potter, J. Pinto, Michelle S. Parvatiyar, 2010, Journal of biomedicine & biotechnology.

Oxidative Stress in Muscle Diseases: Current and Future Therapy

A. Vasconsuelo, J. Pinto, Marko D. Prokić, 2018, Oxidative medicine and cellular longevity.

Redox state of troponin C cysteine in the D/E helix alters the C-domain affinity for the thin filament of vertebrate striated muscle.

J. Pinto, V. D. de Sousa, M. Sorenson, 2011, Biochimica et biophysica acta.

Genotype‐specific pathogenic effects in human dilated cardiomyopathy

F. Asselbergs, A. Vink, M. Harakalova, 2017, The Journal of physiology.

Cardiomyocyte nuclearity and ploidy: when is double trouble?

P. Chase, Maicon Landim-Vieira, J. Pinto, 2019, Journal of Muscle Research and Cell Motility.

Pathogenic troponin T mutants with opposing effects on myofilament Ca2+ sensitivity attenuate cardiomyopathy phenotypes in mice.

Ferhaan Ahmad, S. Huke, B. Knollmann, 2019, Archives of biochemistry and biophysics.

Clinical and Functional Characterization of TNNT2 Mutations Identified in Patients With Dilated Cardiomyopathy

J. Potter, R. Hershberger, Duanxiang Li, 2009, Circulation. Cardiovascular genetics.

Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin.

M. Delp, J. Caldwell, J. Muller-Delp, 2021, American journal of physiology. Heart and circulatory physiology.

Myofilament calcium de-sensitization and contractile uncoupling prevent pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction.

F. Baudenbacher, B. Knollmann, H. Hwang, 2013, Journal of molecular and cellular cardiology.

Increases of desmin and α-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction.

J. Jin, H. Feng, J. Pinto, 2016, Journal of molecular and cellular cardiology.

Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction

T. Irving, J. Lorenz, S. Sadayappan, 2021, Proceedings of the National Academy of Sciences.

Functional Characterization of TNNC1 Rare Variants Identified in Dilated Cardiomyopathy*

N. Norton, J. Potter, R. Hershberger, 2011, The Journal of Biological Chemistry.

Fluorescent Protein-Based Ca2+ Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin C

M. Davidson, P. Chase, J. Pinto, 2016, PloS one.

Analysis of the molecular pathogenesis of cardiomyopathy-causing cTnT mutants I79N, ΔE96, and ΔK210.

M. Kawai, F. Bai, J. Pinto, 2013, Biophysical journal.

Functional Consequences of the Human Cardiac Troponin I Hypertrophic Cardiomyopathy Mutation R145G in Transgenic Mice*

A. Gomes, J. Potter, W. Kerrick, 2008, Journal of Biological Chemistry.

A Troponin T Mutation That Causes Infantile Restrictive Cardiomyopathy Increases Ca2+ Sensitivity of Force Development and Impairs the Inhibitory Properties of Troponin*

J. Potter, Michelle A Jones, Jingsheng Liang, 2008, Journal of Biological Chemistry.

Arrhythmogenic Cardiomyopathy: Exercise Pitfalls, Role of Connexin-43, and Moving beyond Antiarrhythmics

S. Chelko, J. Pinto, Stephen P. Chelko, 2022, International journal of molecular sciences.

Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in Vivo*

A. Baker, J. Stull, Joseph A. Hill, 2015, The Journal of Biological Chemistry.

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene.

M. Ackerman, M. Vukmirovic, J. Bos, 2015, Circulation. Cardiovascular genetics.

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 is a Hypertrophic Cardiomyopathy Susceptibility Gene

M. Vukmirovic, D. Zorio, M. Sanchez-Gonzalez, 2014 .

Oxidative Stress in Muscle Diseases: Current and Future Therapy 2019

G. Arsa, A. Vasconsuelo, J. Pinto, 2020, Oxidative medicine and cellular longevity.

Myosin cross-bridges do not form precise rigor bonds in hypertrophic heart muscle carrying troponin T mutations.

J. Potter, I. Gryczynski, Z. Gryczynski, 2011, Journal of molecular and cellular cardiology.

Fetal Cardiac Troponin Isoforms Rescue the Increased Ca2+ Sensitivity Produced by a Novel Double Deletion in Cardiac Troponin T Linked to Restrictive Cardiomyopathy

J. Potter, G. Andelfinger, Marc-Phillip Hitz, 2011, The Journal of Biological Chemistry.

Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin

J. Potter, N. Greenfield, Audrey N. Chang, 2014, Front. Physiol..

Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.

B. Knollmann, S. Parikh, J. Pinto, 2018, Journal of molecular and cellular cardiology.

Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy.

B. Knollmann, S. Parikh, J. Pinto, 2017, Journal of the American College of Cardiology.

A Dilated Cardiomyopathy Troponin C Mutation Lowers Contractile Force by Reducing Strong Myosin-Actin Binding*

J. Potter, J. Pinto, D. Dweck, 2010, The Journal of Biological Chemistry.

On 'The content of troponin, tropomyosin, actin, and myosin in rabbit skeletal muscle myofibrils' by James D. Potter.

J. Pinto, Michelle S. Parvatiyar, 2022, Archives of biochemistry and biophysics.

Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.

J. Chalovich, J. Pinto, Dylan Johnson, 2017, Biochemistry.

Modulation of troponin C affinity for the thin filament by different cross-bridge states in skinned skeletal muscle fibers

J. Pinto, M. Sorenson, T. Veltri, 2008, Pflügers Archiv - European Journal of Physiology.

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy

C. D. dos Remedios, B. Knollmann, C. Redwood, 2022, Journal of molecular and cellular cardiology plus.

Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy.

J. Potter, J. Jin, Jie Tian, 2010, Journal of molecular and cellular cardiology.

In Vivo Analysis of Troponin C Knock-In (A8V) MiceCLINICAL PERSPECTIVE

M. Ackerman, M. Vukmirovic, J. Bos, 2015 .

Mandibular muscle troponin of the Florida carpenter ant Camponotus floridanus: extending our insights into invertebrate Ca2+ regulation

B. Washburn, P. Chase, Grayson Platt, 2021, Journal of muscle research and cell motility.

Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C.

J. Hasbun, H. Zot, Maicon Landim-Vieira, 2015, Archives of biochemistry and biophysics.

Ca(2+) and Mg(2+) binding to weak sites of TnC C-domain induces exposure of a large hydrophobic surface that leads to loss of TnC from the thin filament.

D. Foguel, Jerson L. Silva, C. Braga, 2006, The international journal of biochemistry & cell biology.

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C

Jerson L. Silva, Guilherme A. P. de Oliveira, M. A. Marques, 2017, Scientific Reports.

Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy*

F. Fincham, M. Kabbaj, J. Hare, 2014, The Journal of Biological Chemistry.

Myofibril orientation as a metric for characterizing heart disease

T. Irving, A. Cammarato, M. Papadaki, 2021, bioRxiv.

The Functional Properties of Human Slow Skeletal Troponin T Isoforms in Cardiac Muscle Regulation*

A. Gomes, J. Potter, T. Miller, 2012, The Journal of Biological Chemistry.

Mandibular muscle troponin of the Florida carpenter ant Camponotus floridanus: extending our insights into invertebrate Ca2+ regulation

B. Washburn, P. Chase, Grayson Platt, 2021, Journal of Muscle Research and Cell Motility.

Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation

P. Chase, A. Landstrom, Maicon Landim-Vieira, 2017, Front. Physiol..

Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.

J. Pinto, Michelle S. Parvatiyar, 2015, Biochimica et biophysica acta.

A Mutation in TNNC1-encoded Cardiac Troponin C, TNNC1-A31S, Predisposes to Hypertrophic Cardiomyopathy and Ventricular Fibrillation*

J. Potter, M. Ackerman, A. Landstrom, 2012, The Journal of Biological Chemistry.

Late Onset Sporadic Dilated Cardiomyopathy Caused by a Cardiac Troponin T Mutation

J. Potter, Duanxiang Li, A. Morales, 2010, Clinical and translational science.

Predicting Cardiomyopathic Phenotypes by Altering Ca2+ Affinity of Cardiac Troponin C*

J. Potter, Jose Renato Pinto, Michelle S Parvatiyar, 2010, The Journal of Biological Chemistry.

A Functional and Structural Study of Troponin C Mutations Related to Hypertrophic Cardiomyopathy*

Michael J Ackerman, J. Potter, M. Ackerman, 2009, The Journal of Biological Chemistry.

Basic residues within the cardiac troponin T C terminus are required for full inhibition of muscle contraction and limit activation by calcium

J. Chalovich, Maicon Landim-Vieira, J. Pinto, 2019, The Journal of Biological Chemistry.

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C

Jerson L. Silva, Guilherme A. P. de Oliveira, M. A. Marques, 2017, Scientific Reports.

The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation

P. Chase, Jerson L. Silva, Guilherme A. P. de Oliveira, 2019, The Journal of Biological Chemistry.

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

M. Regnier, P. Chase, M. Childers, 2022, eLife.

Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction

P. Chase, J. Pinto, Jamie R. Johnston, 2017, Oncotarget.

Eliminating the First Inactive State and Stabilizing the Active State of the Cardiac Regulatory System Alters Behavior in Solution and in Ordered Systems.

J. M. Robinson, J. Chalovich, Maicon Landim-Vieira, 2020, Biochemistry.

Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hotspots that are associated with worse clinical outcomes.

S. Datta, P. Chase, Jeffrey J. Kim, 2020, Journal of molecular and cellular cardiology.

Suppression of lusitropy as a disease mechanism in cardiomyopathies

Steven B Marston, J. Pinto, 2023, Frontiers in Cardiovascular Medicine.

The missing links within troponin.

Wei Yang, Guilherme A. P. de Oliveira, M. A. Marques, 2019, Archives of biochemistry and biophysics.

Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle.

T. Irving, Weikang Ma, O. Antipova, 2018, Journal of molecular and cellular cardiology.

Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function?

A. Gomes, J. Potter, Audrey N. Chang, 2010, Journal of molecular and cellular cardiology.

Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy†

P. Chase, Jerson L. Silva, E. Cino, 2021, Chemical science.

The structure of the native cardiac thin filament at systolic Ca2+ levels

P. Chase, V. Galkin, H. White, 2021, Proceedings of the National Academy of Sciences.

A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C

P. Chase, A. Landstrom, Maicon Landim-Vieira, 2020, Journal of Muscle Research and Cell Motility.

Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion*

Jerson L. Silva, M. Pedrote, Guilherme A. P. de Oliveira, 2017, The Journal of Biological Chemistry.

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C.

S. Ommen, J. Potter, D. Tester, 2007, Journal of molecular and cellular cardiology.

Mechanical contribution to muscle thin filament activation

P. Chase, J. Hasbun, H. Zot, 2020, The Journal of Biological Chemistry.

Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium.

T. Irving, L. Medne, C. Ottenheijm, 2021, The Journal of clinical investigation.

Etiology of genetic muscle disorders induced by mutations in fast and slow skeletal MyBP-C paralogs

S. Sadayappan, J. Pinto, Taejeong Song, 2023, Experimental & Molecular Medicine.

High-resolution cryo-EM structure of the junction region of the native cardiac thin filament in relaxed state

P. Chase, V. Galkin, H. White, 2022, PNAS nexus.

Troponins, intrinsic disorder, and cardiomyopathy

V. Uversky, Insung Na, Shelby C Straight, 2016, Biological chemistry.

Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.

Veniamin Y Sidorov, J. Potter, F. Baudenbacher, 2008, The Journal of clinical investigation.

Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C.

J. Hasbun, H. Zot, Maicon Landim-Vieira, 2015, Archives of biochemistry and biophysics.

Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy

P. Chase, J. Pinto, Michelle S. Parvatiyar, 2020, Physiological reports.

Pathogenesis of depression‐ and anxiety‐like behavior in an animal model of hypertrophic cardiomyopathy

S. Grant, M. Kabbaj, A. Dossat, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Strong Cross-bridges Potentiate the Ca2+ Affinity Changes Produced by Hypertrophic Cardiomyopathy Cardiac Troponin C Mutants in Myofilaments

J. Potter, Jingsheng Liang, J. Pinto, 2010, The Journal of Biological Chemistry.

Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes

C. Poggesi, M. Harakalova, M. Michels, 2020, Journal of molecular and cellular cardiology.

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and non-ischemic human hearts

M. Regnier, P. Chase, M. Childers, 2021, bioRxiv.

Functional effects of a restrictive-cardiomyopathy-linked cardiac troponin I mutation (R145W) in transgenic mice.

J. Potter, W. Kerrick, Yuhui Wen, 2009, Journal of molecular biology.

Strong Cross-bridges Potentiate the Ca 2 (cid:1) Affinity Changes Produced by Hypertrophic Cardiomyopathy Cardiac Troponin C Mutants in Myofilaments A FAST KINETIC APPROACH *

J. Potter, Jingsheng Liang, J. Pinto, 2010 .

A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C

P. Chase, A. Landstrom, Maicon Landim-Vieira, 2020, Journal of Muscle Research and Cell Motility.

Allosteric transmission in cardiac Troponin C 1 Allosteric transmission along a loosely structured backbone allows a cardiac Troponin C mutant to function with only one Ca

M. Pedrote, L. Jerson, Silva, 2016 .

Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice.

A. Bianco, E. L. Olivares, J. Hare, 2012, Molecular endocrinology.

Will you still need me (Ca2+, TnT, and DHPR), will you still cleave me (calpain), when I'm 64?

P. Chase, J. Muller-Delp, J. Pinto, 2016, Aging cell.

Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function

C. Ottenheijm, P. Chase, M. Papadaki, 2023, Proceedings of the National Academy of Sciences of the United States of America.

S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.

J. Thompson, M. Moseley, J. Hare, 2015, Antioxidants & redox signaling.

Micro-mechanical response and power-law exponents from the longitudinal fluctuations of F-actin solutions

S. Jeney, P. Domínguez-García, A. Akrap, 2023, Soft Matter.

Myosin Rod Hypophosphorylation and CB Kinetics in Papillary Muscles from a TnC-A8V KI Mouse Model.

M. Kawai, J. Pinto, Li Wang, 2017, Biophysical journal.

Nucleus Mechanosensing in Cardiomyocytes

P. Chase, J. Irianto, J. Pinto, 2023, International journal of molecular sciences.

Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy*

J. Potter, Ying Ge, Jeffery W. Walker, 2011, The Journal of Biological Chemistry.

Efficacy and Safety of Angiotensin Receptor Blockers in a Pre-Clinical Model of Arrhythmogenic Cardiomyopathy

D. Judge, S. Chelko, Nuria Amat-Alarcon, 2022, International journal of molecular sciences.

Pathogenesis of depression‐ and anxiety‐like behavior in an animal model of hypertrophic cardiomyopathy

S. Grant, M. Kabbaj, A. Dossat, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Abstract 539: Molecular and Functional Characterization of Novel Hypertrophic Cardiomyopathy Susceptibility Mutations in TNNC1-Encoded Troponin C

S. Ommen, J. Potter, M. L. Marquardt, 2007 .

Functional Characterization of TNNC1 Rare Variants Identified in Dilated Cardiomyopathy*

N. Norton, J. Potter, R. Hershberger, 2011, The Journal of Biological Chemistry.

The intrinsically disordered carboxy-terminus of troponin-T binds to troponin-C to modulate myocardial force generation

P. Chase, Jerson L. Silva, M. A. Marques, 2019 .

Negative Charges Introduced Near the IT Helix of Cardiac Troponin T Stabilize the Active State of Actin Filaments.

J. Chalovich, Maicon Landim-Vieira, J. Pinto, 2023, Biochemistry.

Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2

P. Chase, P. Kekenes-Huskey, Weikang Ma, 2023, International journal of molecular sciences.