C. Houle

发表

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.

R. Kurumbail, B. L. Kormos, M. Hayward, 2015, Journal of medicinal chemistry.

Neuropathology Standards

C. Houle, 2011, Toxicologic pathology.

Characterization of cachexia in the human fibrosarcoma HT‐1080 mouse tumour model

Jeonifer M. Garren, S. Qiao, Zhidan Wu, 2020, Journal of cachexia, sarcopenia and muscle.

Mutant Brca2/p53 mice exhibit altered radiation responses in the developing mammary gland.

S. Peddada, B. Davis, W. Gersch, 2005, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Loss of expression and altered localization of KAI1 and CD9 protein are associated with epithelial ovarian cancer progression.

J. Barrett, C. Afshari, J. Foley, 2002, Gynecologic oncology.

Spontaneous and Irradiation-Induced Tumor Susceptibility in Brca2 Germline Mutant Mice and Cooperative Effects with a p53 Germline Mutation

L. Bennett, R. Wiseman, B. Davis, 2006, Toxicologic pathology.

Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.

J. Haseman, L. Bennett, R. Wiseman, 2002, Cancer research.

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.

R. Kurumbail, B. L. Kormos, P. Verhoest, 2014, Bioorganic & medicinal chemistry letters.

Identification of MHC Haplotypes Associated with Drug-induced Hypersensitivity Reactions in Cynomolgus Monkeys

Hong Wu, J. Whritenour, C. Houle, 2017, Toxicologic pathology.

Use of Rat Primary Mesenteric Cells for the Prediction of PDE4 Inhibitor Drug-Induced Vascular Injury

Bradley E. Enerson, R. Chapin, T. Wisialowski, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Advances in Brief Cancer Susceptibility of Mice with a Homozygous Deletion in the COOH-Terminal Domain of the Brca 2 Gene 1

J. Haseman, L. Bennett, R. Wiseman, 2002 .

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

Matthew L. Maddess, A. Stepan, T. Sherer, 2020, Science Translational Medicine.

LRRK2 kinase inhibitors induce a reversible effect in the lungs of non-human primates with no measurable pulmonary deficits

Matthew L. Maddess, A. Stepan, T. Sherer, 2018, bioRxiv.

Protective effect of pregnancy for development of uterine leiomyoma.

D. Baird, J. Barrett, C. Walker, 2001, Carcinogenesis.

Histologic and Cytologic Detection of Endocrine and Reproductive Tract Effects of Exemestane in Female Rats Treated for up to Twenty-eight Days

R. Chapin, G. Cappon, M. Mirsky, 2011, Toxicologic pathology.

Cardiovascular involvement in 8 dogs with blastomyces dermatitidis infection.

C. Schmiedt, J. Bright, R. Gompf, 2006, Journal of veterinary internal medicine.

Overview of the Molecular Biology of Hepatocellular Neoplasms and Hepatoblastomas of the Mouse Liver

R. Sills, Yongbaek Kim, C. Houle, 2005, Toxicologic pathology.

K-ras Mutations in Lung Tumors and Tumors from Other Organs are Consistent with a Common Mechanism of Ethylene Oxide Tumorigenesis in the B6C3F1 Mouse

R. Sills, T. Ton, H. L. Hong, 2007, Toxicologic pathology.

Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.

E. Berg, A. Stepan, R. Stanton, 2017, Cell chemical biology.

Vitamin E deficiency and pansteatitis in juvenile boat-billed herons (Cochlearius cochlearius).

J. Sleeman, C. Houle, C. Pollock, 1999, Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.

Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents.

J. Aubrecht, S. Schomaker, Lina Luo, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Using Histopathologic Evidence to Differentiate Reproductive Senescence from Xenobiotic Effects in Middle-aged Female Sprague-Dawley Rats

M. Mirsky, N. Shirai, C. Houle, 2015, Toxicologic pathology.

R. Chapin, G. Cappon, S. Campion, 2015, Reproductive toxicology.

Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.

K. Tomer, R. Paules, S. Sieber, 2003, Carcinogenesis.

Effects of Lersivirine on Canine and Rodent Thyroid Function

I. Gardner, R. Mauthe, G. Finch, 2014, Toxicologic pathology.

Frequent p53 and H-ras Mutations in Benzene- and Ethylene Oxide-Induced Mammary Gland Carcinomas from B6C3F1 Mice

J. Huff, R. Sills, N. Clayton, 2006, Toxicologic pathology.

Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Graham M. West, Sherry L. Niessen, Claude Ambroise, 2016, Nature Communications.

Species differences in the multiple-dose pharmacokinetics of the non-nucleoside reverse transcriptase inhibitor (NNRTI) UK-453,061 in animals and man: implications for safety considerations

D. Walker, I. Gardner, J. Davis, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.

Claude Ambroise, D. Karanian, K. Bales, 2018, Journal of medicinal chemistry.

Primary cell cultures for understanding rat epididymal inflammation.

D. Karanian, R. Chapin, T. Coskran, 2014, Birth defects research. Part B, Developmental and reproductive toxicology.

Two-year Carcinogenicity Study in Rats with a Nonnucleoside Reverse Transcriptase Inhibitor

Steven A. Bailey, P. Nambiar, P. Thomford, 2015, Toxicologic pathology.

Publication Categories in Toxicologic Pathology

S. Elmore, K. Colman, J. Werner, 2021, Toxicologic pathology.

Gastric Neuroendocrine Tumors With Parietal Cell Atrophy in a Long-term Carcinogenicity Study in Rats

N. Shirai, C. Houle, S. Choudhary, 2022, Toxicologic pathology.

Drug-induced Skin Lesions in Cynomolgus Macaques Treated with Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulators

G. Cappon, C. L. Shaffer, J. Whritenour, 2015, Toxicologic pathology.

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.

J. Cianfrogna, A. Stepan, Daniel P. Walker, 2017, Journal of medicinal chemistry.

An in vitro alveolar epithelial cell model recapitulates LRRK2 inhibitor-induced increases in lamellar body size observed in preclinical models.

C. Somps, P. Bajaj, A. Kopec, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Perspectives on Drug-induced Vascular Injury

D. Morton, C. Houle, Lindsay Tomlinson, 2014, Toxicologic pathology (Print).