N. Handa

发表

Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form.

S. Sugano, S. Yokoyama, T. Terada, 2007, Acta crystallographica. Section D, Biological crystallography.

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.

K. Ogawa, T. Umehara, S. Yokoyama, 2016, Journal of medicinal chemistry.

A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo

Satoshi Tanaka, Shigeyuki Yokoyama, Hiroshi Kajita, 2013, Science Translational Medicine.

Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line

E. Kinoshita, K. Hanada, G. Kajiyama, 1997, FEBS letters.

Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives.

T. Umehara, S. Yokoyama, M. Shirouzu, 2013, Acta crystallographica. Section D, Biological crystallography.

Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor.

S. Yokoyama, M. Shirouzu, T. Honma, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Chemistry of lipids of posthemolytic residue or stroma of erythrocytes. XI. Structure of globoside, the main mucolipid of human erythrocytes.

T. Yamakawa, N. Handa, S. Yokoyama, 1963, Journal of biochemistry.

An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus.

R. Tanaka, Takeshi Yamada, N. Handa, 2010, Phytochemistry.

Four new lanostane-type triterpenoids from Inonotus obliquus

R. Tanaka, Takeshi Yamada, N. Handa, 2012 .

Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches

K. Miyazono, S. Yokoyama, M. Shirouzu, 2020, ACS omega.

Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).

K. Miyazono, S. Yokoyama, M. Shirouzu, 2019, Chemical & pharmaceutical bulletin.

Biochemical and structural studies on the high affinity of Hsp70 for ADP

Shigeyuki Yokoyama, Mikako Shirouzu, S. Yokoyama, 2011, Protein science : a publication of the Protein Society.

The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.

T. Kigawa, S. Yokoyama, M. Shirouzu, 2010, Structure.

Crystal structures of the S6K1 kinase domain in complexes with inhibitors

S. Yokoyama, M. Shirouzu, T. Honma, 2014, Journal of Structural and Functional Genomics.

Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor

S. Sano, S. Yokoyama, Lin Chen, 2013, Oncogene.

A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide.

S. Yokoyama, T. Honma, T. Nagano, 2012, Journal of molecular biology.

Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68.

Tomoatsu Hayashi, T. Akiyama, S. Yokoyama, 2011, Structure.

ZF21 Protein, a Regulator of the Disassembly of Focal Adhesions and Cancer Metastasis, Contains a Novel Noncanonical Pleckstrin Homology Domain*

T. Kigawa, S. Yokoyama, Satoru Watanabe, 2011, The Journal of Biological Chemistry.

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain.

S. Yokoyama, T. Terada, M. Shirouzu, 2011, Acta crystallographica. Section D, Biological crystallography.

The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain.

Y. Hayashizaki, T. Kigawa, S. Yokoyama, 2006, Journal of molecular biology.

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein

Kazuki Kurimoto, Shigeyuki Yokoyama, Osamu Nureki, 1999, Nature.

Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.

S. Yokoyama, T. Honma, D. Takaya, 2020, Journal of molecular graphics & modelling.

Crystal structure of the conserved protein TT1542 from Thermus thermophilus HB8

Kengo Kinoshita, Haruki Nakamura, Motonori Ota, 2003, Protein science : a publication of the Protein Society.

Crystal structure of a novel polyisoprenoid‐binding protein from Thermus thermophilus HB8

S. Yokoyama, J. Tame, Sam-Yong Park, 2005, Protein science : a publication of the Protein Society.

Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP*

S. Yokoyama, J. Kotera, K. Omori, 2008, Journal of Biological Chemistry.

Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97).

T. Akiyama, S. Yokoyama, M. Shirouzu, 2013, Biochemical and biophysical research communications.

Development and Structural Evaluation of N‐Alkylated trans‐2‐Phenylcyclopropylamine‐Based LSD1 Inhibitors

T. Umehara, S. Yokoyama, N. Handa, 2020, ChemMedChem.

Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.

S. Yokoyama, M. Shirouzu, A. Tanaka, 2014, Acta crystallographica. Section D, Biological crystallography.

Development and Structural Evaluation of N-alkylated Trans-2-phenylcyclopropylamine-based LSD1 Inhibitors.

T. Umehara, S. Yokoyama, N. Handa, 2020 .

Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP*

S. Yokoyama, J. Kotera, K. Omori, 2008, Journal of Biological Chemistry.

Structure of the UNC5H2 death domain.

Y. Hayashizaki, T. Kigawa, S. Yokoyama, 2006, Acta crystallographica. Section D, Biological crystallography.