B. Ksienzyk

发表

Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia

H. Leonhardt, K. Spiekermann, S. Bohlander, 2011, Leukemia.

Combined molecular and clinical prognostic index for relapse and survival in cytogenetically normal acute myeloid leukemia.

Guido Marcucci, Christian Buske, Michael Unterhalt, 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The clinical mutatome of core binding factor leukemia

W. Hiddemann, K. Metzeler, S. Bohlander, 2020, Leukemia.

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.

W. Hiddemann, S. Bohlander, H. Blum, 2012, Blood.

Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia

W. Hiddemann, K. Metzeler, S. Bohlander, 2019, Scientific Reports.

Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia

W. Hiddemann, K. Metzeler, S. Bohlander, 2018, Oncotarget.

Compartment-specific mutational landscape of clonal hematopoiesis

K. Metzeler, K. Götze, F. Bassermann, 2022, Leukemia.

Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4

W. Hiddemann, K. Metzeler, S. Bohlander, 2017, Genes, chromosomes & cancer.

Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

W. Hiddemann, K. Metzeler, S. Bohlander, 2017, Leukemia.

CHIP & HIPs: Clonal Hematopoiesis is Common in Hip Arthroplasty Patients and Associates with Autoimmune Disease.

K. Metzeler, K. Götze, F. Bassermann, 2021, Blood.

High Frequency of GATA2 Mutations in Cytogenetically Normal Acute Myeloid Leukemia with Biallelic CEBPA Mutations Identified by Exome Sequencing

W. Hiddemann, S. Bohlander, H. Blum, 2011 .

DNMT3A Mutations Associate with Shorter Survival and Modulate the Prognostic Impact of Mutated NPM1: an Analysis Based on Comprehensive Mutational Screening of 660 AML Patients Treated on German AML Cooperative Group (AMLCG) Trials

W. Hiddemann, K. Metzeler, S. Bohlander, 2015 .

Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis

K. Metzeler, S. Bohlander, K. Spiekermann, 2022, Cancer.

Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia

W. Hiddemann, K. Metzeler, S. Bohlander, 2020, Leukemia.

Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis.

Ulrich Mansmann, Sebastian Vosberg, Wolfgang Hiddemann, 2014, Blood.

Loss of KDM6A confers drug resistance in acute myeloid leukemia

W. Hiddemann, K. Metzeler, G. Schotta, 2018, Leukemia.

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.

S. Bohlander, H. Blum, P. Greif, 2013, Blood.

Adults with Philadelphia chromosome–like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis

W. Hiddemann, K. Metzeler, S. Bohlander, 2017, Haematologica.

Monoallelic CEBPA mutations in normal karyotype acute myeloid leukemia: independent favorable prognostic factor within NPM1 mutated patients

E. Hoster, W. Hiddemann, S. Bohlander, 2012, Annals of Hematology.

Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia

W. Hiddemann, K. Metzeler, S. Bohlander, 2020, Leukemia.

Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with Acute Myeloid Leukaemia

W. Hiddemann, K. Metzeler, S. Bohlander, 2020, medRxiv.

RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes

Wolfgang Hiddemann, Tobias Herold, Karsten Spiekermann, 2012, Haematologica.

Philadelphia chromosome – like acute lymphoblastic leukemia in adults have frequent IGH-CRLF 2 and JAK 2 mutations , persistence of minimal residual disease and poor prognosis

W. Hiddemann, K. Metzeler, S. Bohlander, 2016 .

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia.

E. Hoster, W. Hiddemann, S. Bohlander, 2012, Blood.

Running title : GATA 2 mutations in bi CEBPA AML 1 GATA 2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia *

E. Hoster, W. Hiddemann, S. Bohlander, 2012 .

Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing

S. Bohlander, H. Blum, P. Greif, 2011, Leukemia.

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.

W. Hiddemann, K. Metzeler, S. Bohlander, 2016, Blood.

A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia

Ulrich Mansmann, Philipp A. Greif, Klaus H. Metzeler, 2017, Haematologica.

Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older

W. Hiddemann, K. Metzeler, S. Bohlander, 2018, Haematologica.

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation

W. Hiddemann, K. Metzeler, S. Bohlander, 2016, Nature Communications.

Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

W. Hiddemann, I. Hellmann, K. Metzeler, 2018, Clinical Cancer Research.

The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML

Philipp A. Greif, Wolfgang Hiddemann, Karsten Spiekermann, 2014, PloS one.

Persistence of driver mutations during complete remission associates with shorter survival and contributes to the inferior outcomes of elderly patients with acute myeloid leukemia

W. Hiddemann, K. Metzeler, S. Bohlander, 2016 .

Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia

W. Hiddemann, K. Metzeler, S. Bohlander, 2019, Scientific Reports.

Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA.

E. Hoster, W. Hiddemann, K. Metzeler, 2018, Blood advances.

Analysis of Cooperating Genetic Events in MLLT3-MLL Rearranged Acute Myeloid Leukemia (AML) by Targeted Next-Generation Sequencing of 16 Leukemia-Related Genes Reveals Frequent Mutations Affecting Growth Factor Signalling Pathways and Provides Evidence for Clonal Heterogeneity

W. Hiddemann, K. Metzeler, S. Bohlander, 2012 .

Germline SNPs previously implicated as prognostic biomarkers do not associate with outcomes in intensively treated AML

W. Hiddemann, K. Metzeler, K. Spiekermann, 2022, Blood advances.

NPM1 Variant Allele Frequency and Outcomes in AML

W. Hiddemann, K. Metzeler, S. Bohlander, 2018, Blood.

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT 3 A mutations

S. Bohlander, H. Blum, P. Greif, 2013 .

Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing

T. Meitinger, T. Strom, S. Bohlander, 2011, Leukemia.

Acute Myeloid Leukemia With Isolated Trisomy 13 Is a Genetically Homogenous Entity With a High Frequency Of Mutations In Genes Encoding Components Of The Splicing Machinery and Extremely Poor Prognosis

W. Hiddemann, K. Metzeler, S. Bohlander, 2013 .

Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome

W. Hiddemann, K. Metzeler, K. Spiekermann, 2023, British journal of haematology.

Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia.

W. Hiddemann, K. Metzeler, K. Spiekermann, 2017, Leukemia.

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models

E. Wolf, K. Metzeler, S. Bohlander, 2016, Leukemia.

Clinical presentation and differential splicing of SRSF2 , U2AF1 and SF3B1 mutations in 2 patients with Acute Myeloid Leukaemia 3 4 Characterization of SF mutations in AML 5

K. Metzeler, S. Bohlander, U. Mansmann, 2019 .

Clinical presentation and differential splicing of SRSF2 , U2AF1 and SF3B1 mutations in 2 patients with Acute Myeloid Leukaemia 3 4 Characterization of SF mutations in AML 5

K. Metzeler, S. Bohlander, U. Mansmann, 2019 .

Monoallelic CEBPA mutations in normal karyotype acute myeloid leukemia: independent favorable prognostic factor within NPM1 mutated patients

E. Hoster, W. Hiddemann, S. Bohlander, 2012, Annals of Hematology.

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.

W. Hiddemann, S. Bohlander, H. Blum, 2012, Blood.