A. Omar

发表

Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

M. Safo, P. P. Pagare, Yan Zhang, 2021, Expert opinion on therapeutic patents.

Phytoconstituents, In Vitro Anti-Infective Activity of Buddleja indica Lam., and In Silico Evaluation of its SARS-CoV-2 Inhibitory Potential

A. Altyar, F. Youssef, M. Ashour, 2021, Frontiers in Pharmacology.

Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1,2,3-triazole fragment that mimic quinazoline epidermal growth factor receptor inhibitors: Synthesis, antitumor and mechanistic analyses.

Saleh K. Ihmaid, Hany E. A. Ahmed, N. Rezki, 2020, Bioorganic chemistry.

Discovery and SAR of Novel Disubstituted Quinazolines as Dual PI3Kalpha/mTOR Inhibitors Targeting Breast Cancer.

Khaled M. Elokely, M. Rico, W. Childers, 2020, ACS medicinal chemistry letters.

1H-Imidazole-2,5-Dicarboxamides as NS4A Peptidomimetics: Identification of a New Approach to Inhibit HCV-NS3 Protease

S. Arold, Hani Asfour, S. Soror, 2020, Biomolecules.

1H-Imidazole-2,5-Dicarboxamides as NS4A Peptidomimetics: Identification of a New Venue to Inhibit HCV-NS3 Protease

S. Arold, Hani Asfour, S. Soror, 2020 .

Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects.

Saleh K. Ihmaid, J. Bajorath, Hany E. A. Ahmed, 2020, Bioorganic chemistry.

Design, Synthesis and in Vivo Anti-inflammatory Activities of 2,4-Diaryl-5-4H-imidazolone Derivatives

Abdel-Ghany A. El-Helby, A. Omar, A. A. Abdel-Rahman, 2012, Molecules.

Design, Synthesis and in Vivo Anti-inflammatory Activities of 2,4-Diaryl-5-4H-imidazolone Derivatives

Abdel-Ghany A. El-Helby, A. Omar, A. A. Abdel-Rahman, 2012, Molecules.

In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-MPro inhibitors

Saleh K. Ihmaid, Hany E. A. Ahmed, H. Patel, 2022, RSC advances.

SAR Probing of KX2-391 Provided Analogues With Juxtaposed Activity Profile Against Major Oncogenic Kinases

D. Shah, W. Childers, Azizah M Malebari, 2022, Frontiers in Oncology.

Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics

K. El-Say, M. Khayat, A. Omar, 2022, Heteroatom Chemistry.

Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease

S. Arold, Hani Asfour, Sameh H. Soror, 2020, Journal of advanced research.

Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents.

M. Safo, M. Ghatge, O. Abdulmalik, 2015, Organic & biomolecular chemistry.

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease

T. McMahon, Boshi Huang, M. Telen, 2022, Molecules.

Advances in Fungal Phenaloenones—Natural Metabolites with Great Promise: Biosynthesis, Bioactivities, and an In Silico Evaluation of Their Potential as Human Glucose Transporter 1 Inhibitors

Jianbo Xiao, G. Mohamed, H. Abdallah, 2022, Molecules.

Synthesis and evaluation of novel N-substituted N'-(3-hydroxy-17-oxoestra-1,3,5(10)-trien-2- and -4-yl)thiourea derivatives for binding to the estrogen receptor and cytotoxic activity on MCF-7 cells.

G. Leclercq, O. Aboulwafa, A. Omar, 1984, Journal of pharmaceutical sciences.

Exploring the dual effect of novel 1,4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms

Saleh K. Ihmaid, A. El-Agrody, Azizah M Malebari, 2022, Bioorganic Chemistry.

Exploring the Activity of Fungal Phenalenone Derivatives as Potential CK2 Inhibitors Using Computational Methods

G. Mohamed, S. Ibrahim, A. Bagalagel, 2022, Journal of fungi.

Syntheses of Some Substituted Isatin‐β‐thiosemicarbazones and Isatin‐β‐hydrazonothiazoline Derivatives as Potential Antiviral and Antimicrobial Agents

A. Omar, N. H. Eshba, H. M. Salama, 1984 .

Potential broad spectrum anthelmintics IV: design, synthesis, and antiparasitic screening of certain 3,6-disubstituted-(7H)-s-triazolo-[3,4-b][1,3,4]thiadiazine derivatives.

A. Hazzaa, A. Omar, A. M. Ismail, 1983, Journal of pharmaceutical sciences.

Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies.

M. Safo, M. Ghatge, A. Omar, 2021, Biochimie.

Introducing of potent cytotoxic novel 2-(aroylamino)cinnamamide derivatives against colon cancer mediated by dual apoptotic signal activation and oxidative stress.

Mostafa H. Ahmed, Hany E. A. Ahmed, M. Safo, 2020, Bioorganic chemistry.

Discovery, optimization, and cellular activities of 2-(aroylamino)cinnamamide derivatives against colon cancer cells

Mostafa H. Ahmed, M. Safo, M. Abdel-Bakky, 2019, bioRxiv.

Studies on thioamides. 3. A new synthetic method of the 3,4-dihydroisoquinoline derivatives by the cyclodesulfurization of thioamides.

S. Yamada, A. Omar, 1966, Chemical & pharmaceutical bulletin.

Benzoxazole derivatives as new generation of anti-breast cancer agents.

O. Aboulwafa, Mai S El-Shoukrofy, M. Amr, 2020, Bioorganic chemistry.

Synthesis and biological evaluation of new 2,3-dihydrothiazole derivatives for antimicrobial, antihypertensive, and anticonvulsant activities.

A. Omar, N. H. Eshba, 1984, Journal of pharmaceutical sciences.

Synthesis and antihypertensive properties of a novel series of 3‐substituted amino‐s‐triazolo[3,4‐α]phthalazine derivatives

M. Kasem, A. Omar, J. Bourdais, 1981 .

Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor

Hany E. A. Ahmed, A. Asiri, Khaled El-Adl, 2017, Molecules.

Synthesis and screening of some new fluorinated quinazolinone–sulphonamide hybrids as anticancer agents

Hany E. A. Ahmed, A. Omar, M. Zayed, 2015 .

Antiproliferative activity, enzymatic inhibition and apoptosis-promoting effects of benzoxazole-based hybrids on human breast cancer cells.

O. Aboulwafa, Mai S El-Shoukrofy, M. Amr, 2021, Bioorganic chemistry.

Design, synthesis, molecular docking of new lipophilic acetamide derivatives affording potential anticancer and antimicrobial agents.

Hany E. A. Ahmed, M. Elaasser, Sahar Ahmed, 2018, Bioorganic chemistry.

Targeted potent antimicrobial benzochromene-based analogues: Synthesis, computational studies, and inhibitory effect against 14α-Demethylase and DNA Gyrase.

Hany E. A. Ahmed, A. Halawa, Essam M. Eliwa, 2020, Bioorganic chemistry.

Synthesis and anticonvulsant properties of a novel series of 2-substituted amino-5-aryl-1,3,4-oxadiazole derivatives

O. Aboulwafa, A. Omar, 1984 .

Design, facile synthesis and anthelmintic activity of new O-substituted 6-methoxybenzothiazole-2-carbamates. Part II.

I. M. El-Ashmawy, O. Aboulwafa, Mai S El-Shoukrofy, 2015, MedChemComm.

Synthesis, 13C-NMR characterization and antimicrobial properties of a novel series of 3-(N-Substituted thiocarbamoyl)hydrazino-1,2,4-triazino-[5,6-b]indole derivatives

A. Omar, H. M. Aboushleib, N. H. Eshba, 1986 .

SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW 2,3‐DIHYDROTHIAZOLE DERIVATIVES FOR ANTIMICROBIAL, ANTIHYPERTENSIVE, AND ANTICONVULSANT ACTIVITIES

A. Omar, N. H. Eshba, 1985 .

Steroidal thiourea and thiazoline derivatives: synthesis and in vitro effects on bovine pancreatic ribonuclease activity.

S. El-sewedy, O. Aboulwafa, A. Omar, 1983, Journal of pharmaceutical sciences.

Thiourea and thiosemicarbazide derivatives structurally related to hexestrol: synthesis and anticancer and other pharmacological properties.

T. Daabees, A. Omar, A. M. Farghaly, 1981, Journal of pharmaceutical sciences.

The Cyclodesulfurization of Thio Compounds; XVI. Dicyclohexylcarbodiimide as an Efficient Cyclodesulfurizing Agent in the Synthesis of Heterocyclic Compounds from Various Thio Compounds

O. Aboulwafa, A. Omar, N. S. Habib, 1977 .

Synthesis and in vitro antimicrobial and antifungal properties of some novel 1,3,4-thiadiazole and s-triazolo[3,4-b][1,3,4]thiadiazole derivatives

O. Aboulwafa, A. Omar, 1986 .

Polycyclic azines. III. Synthesis of 3‐aminoimidazo[1,5‐a]pyridine derivatives by cyclodesulfurization of N′‐Substituted‐N‐(2‐pyridylmethyl)thioureas with dicyclohexylcarbodiimide

A. Omar, J. Bourdais, 1980 .

The cyelodesulfurization of thio-compounds. Part XVII. Synthesis of some novel 2-substituted amino-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones by cyelodesulfurization of thiosemicarbazides with dicyclohexylearbodiimide (DCCD)

A. Omar, F. Ashour, J. Bourdais, 1979 .

Design, Synthesis and Antiproliferative Activities of Oxidative Stress Inducers Based on 2-Styryl-3,5-dihydro-4H-imidazol-4-one Scaffold.

M. Abdel-Bakky, A. Alahdal, A. Omar, 2018, Chemical & pharmaceutical bulletin.

The Cyclodesulfurization of Thio Compounds; VII. A New Facile Synthesis of Nα-Substituted Benzimidazoles

A. Omar, 1974 .

A single‐step synthesis of 1,3,4, 6‐tetraaryl ‐5‐aryliminopiperazin‐2‐one

A. Omar, M. El‐Araby, 2020, Journal of Heterocyclic Chemistry.

Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B.

Farag F. Sherbiny, Hany E. A. Ahmed, T. H. Afifi, 2020, Bioorganic chemistry.

Novel triazolo[4,3-a]quinazolinone and bis-triazolo[4,3-a:4,3'-c]quinazolines: synthesis and antitoxoplasmosis effect.

K. Ismail, M. El-Azzouni, O. Aboulwafa, 1999, Farmaco.

The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase.

Hany E. A. Ahmed, Sahar Ahmed, Hamada S. Abulkhair, 2020, Bioorganic chemistry.

SYNTHESES OF SOME SUBSTITUTED ISATIN β-THIOSEMICARBAZONES AND ISATIN β-HYDRAZONOTHIAZOLINE DERIVATIVES AS POTENTIAL ANTIVIRAL AND ANTIMICROBIAL AGENTS

A. Omar, N. H. Eshba, H. M. Salama, 1984 .

Synthesis, binding affinities and uterotrophic activity of some 2-substituted estradiol and ring-A-fused pyrone derivatives

K. Ismail, O. Aboulwafa, A. Omar, 1994 .

Chaetomugilins and Chaetoviridins—Promising Natural Metabolites: Structures, Separation, Characterization, Biosynthesis, Bioactivities, Molecular Docking, and Molecular Dynamics

G. Mohamed, S. Ibrahim, A. Omar, 2022, Journal of fungi.

Fungal Bergamotane Sesquiterpenoids—Potential Metabolites: Sources, Bioactivities, and Biosynthesis

G. Mohamed, S. Ibrahim, M. Khayat, 2022, Marine drugs.

Novel potential anticancer agents derived from benzimidazole.

A. Omar, E. S. Ibrahim, M. A. Khalil, 1980, Journal of pharmaceutical sciences.

Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors

G. Mohamed, S. Ibrahim, A. Omar, 2022, Plants.

Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation

M. Safo, O. Ahmed, K. El-Say, 2019, International journal of nanomedicine.

Steroidal oxazoline derivatives: synthesis and in vitro effect on bovine pancreatic ribonuclease activity.

O. Aboulwafa, A. Omar, 1982, Journal of pharmaceutical sciences.

Novel estradiol-17α-1,2,4-triazoline derivatives. Synthesis and in vitro anabolic-catabolic properties and binding affinity to steroid receptors

O. Aboulwafa, A. Omar, 1984 .

4′,17‐Dioxo‐5′H‐estra‐1(10),4‐dieno[3,2‐b]furan: Synthesis, Binding Affinity to the Estrogen Receptor, Uterotrophic and Antiimplantation Activities

O. Aboulwafa, A. Omar, I. Labouta, 1996, Archiv der Pharmazie.

Synthesis and biological evaluation of some novel 2-(pyrimidin-4-yl)estradiol derivatives

K. Ismail, A. Omar, A. A. El-Tombary, 1995 .

STEROIDAL OXAZOLINE DERIVATIVES: SYNTHESIS AND IN VITRO EFFECT ON BOVINE PANCREATIC RIBONUCLEASE ACTIVITY

O. Aboulwafa, A. Omar, 1983 .

Potential steroidal antiestrogens.

E. R. Clark, A. Omar, G. Prestwich, 1977, Journal of medicinal chemistry.

Synthesis and evaluation for uterotrophic and antiimplantation activities of 2-substituted estradiol derivatives

O. Aboulwafa, A. Omar, M. El-Din, 1992, Steroids.

Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect

Ehab S. Taher, M. Safo, Thikryat Neamatallah, 2021, Journal of enzyme inhibition and medicinal chemistry.

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

Boshi Huang, F. Musayev, M. Safo, 2020, Scientific Reports.

Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

M. Safo, Tarek A. Ahmed, F. Abd-Allah, 2021, Pharmaceutics.

An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling

M. Safo, M. Ghatge, O. Abdulmalik, 2020, Biomolecules.

Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

Mostafa H. Ahmed, M. Safo, M. Ghatge, 2016, Molecules.

Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity

N. O’Boyle, Ehab S. Taher, T. Ibrahim, 2020, Pharmaceuticals.

Molecular Mimics of Classic P-Glycoprotein Inhibitors as Multidrug Resistance Suppressors and Their Synergistic Effect on Paclitaxel

A. M. Al-Abd, M. Khayat, A. Omar, 2017, PloS one.

Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction

N. Alhakamy, K. El-Say, A. Omar, 2020, Pharmaceutics.

Synthesis and in vitro Antimicrobial and Antifungal Properties of Some Novel 1,3,4-Thiadiazole and s-Triazolo(3,4-b)(1,3,4)thiadiazole Derivatives.

A. Omar, O. A. Wafa, 1987 .

Unveiling the Efficacy of Sesquiterpenes from Marine Sponge Dactylospongia elegans in Inhibiting Dihydrofolate Reductase Using Docking and Molecular Dynamic Studies

G. Mohamed, S. Ibrahim, A. Omar, 2023, Molecules.

Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants

Thikryat Neamatallah, Azizah M Malebari, Sara Ibrahim, 2022, Frontiers in Pharmacology.

Syntheses of some substituted isatin-beta-thiosemicarbazones and isatin-beta-hydrazonothiazoline derivatives as potential antiviral and antimicrobial agents.

A. Omar, N. H. Eshba, H. M. Salama, 1984, Archiv der Pharmazie.

Mangosteen Metabolites as Promising Alpha-Amylase Inhibitor Candidates: In Silico and In Vitro Evaluations

G. Mohamed, H. Abdallah, S. Ibrahim, 2022, Metabolites.

DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF ANTIBACTERIAL AND ANTIADHESIVE POTENTIALS OF SOME SUBSTITUTED IMIDAZOLONES DERIVATIVES OF CINNAMALDEHYDE

A. Omar, 2016 .

A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses

Hany E. A. Ahmed, A. El-Agrody, Azizah M Malebari, 2023, Journal of biomolecular structure & dynamics.

Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists

G. Mohamed, S. Ibrahim, A. Omar, 2023, Molecules.

Assessments of Alpha-Amylase Inhibitory Potential of Tagetes Flavonoids through In Vitro, Molecular Docking, and Molecular Dynamics Simulation Studies

G. Mohamed, A. Omar, M. El‐Araby, 2023, International journal of molecular sciences.

Docking and Molecular Dynamic Investigations of Phenylspirodrimanes as Cannabinoid Receptor-2 Agonists

M. Safo, G. Mohamed, S. Ibrahim, 2022, Molecules.

Incorporating valsartan in sesame oil enriched self-nanoemulsifying system-loaded liquisolid tablets to improve its bioavailability.

M. Safo, Tarek A. Ahmed, K. El-Say, 2023, International journal of pharmaceutics.

Novel Steroidal 1,4‐Diketones and Pyridazine Derivatives as Potential Antiestrogens.

K. Ismail, O. Aboulwafa, A. Omar, 1997 .

Discovery, Optimization, and Cellular Activities of 2-(Aroylamino)cinnamamide Derivatives Against Colon Cancer

Mostafa H. Ahmed, M. Safo, M. Abdel-Bakky, 2020 .

Potential alkylating agents derived from benzimidazole and benzothiazole.

O. Aboulwafa, A. Omar, N. S. Habib, 1982, Journal of pharmaceutical sciences.

Synthesis and anti-microbial evaluation of 2-methyl-3-substituted-4(3H)-quinazolinones

A. Omar, A. M. Farghaly, H. M. Aboushleib, 1987 .