S. Efthimiopoulos

发表

Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively.

N. Robakis, P. Mehta, J. Ghiso, 1999, Journal of neurochemistry.

Distinct Secretases, a Cysteine Protease and a Serine Protease, Generate the C Termini of Amyloid β‐Proteins Aβ1‐40 and Aβ1‐42, Respectively

N. Robakis, P. Mehta, J. Ghiso, 1999 .

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

N. Robakis, L. Refolo, M. Pappolla, 1995, Journal of neuroscience research.

Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins

N. Robakis, L. Refolo, M. Pappolla, 1995, Neuroscience Letters.

Study of the phorbol ester effect on Alzheimer amyloid precursor processing: Sequence requirements and involvement of a Cholera toxin sensitive protein

L. Refolo, K. Felsenstein, K. Sambamurti, 1994, Journal of neuroscience research.

Abeta(1–40)-induced secretion of matrix metalloproteinase-9 results in sAPPα release by association with cell surface APP

E. Tsilibary, A. Tzinia, M. Figueiredo-Pereira, 2007, Neurobiology of Disease.

Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies.

V. Sarli, S. Thysiadis, S. Katsamakas, 2016, European journal of medicinal chemistry.

Intracellular Cyclic AMP Inhibits Constitutive and Phorbol Ester‐Stimulated Secretory Cleavage of Amyloid Precursor Protein

N. Robakis, M. Pangalos, V. Manolopoulos, 1996, Journal of neurochemistry.

Presenilin 1 and Cadherins: Stabilization of Cell-Cell Adhesion and Proteolysis-Dependent Regulation of Transcription

L. Parisiadou, S. Efthimiopoulos, Ioanna Bethani, 2004, Neurodegenerative Diseases.

Novel Processing of Notch 1 within Its Intracellular Domain by a Cysteine Protease

N. Robakis, L. Parisiadou, S. Efthimiopoulos, 2007, Neurodegenerative Diseases.

Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer's disease.

V. Sarli, S. Thysiadis, S. Katsamakas, 2018, Bioorganic chemistry.

Cell‐Line Specific Protection by Berry Polyphenols Against Hydrogen Peroxide Challenge and Lack of Effect on Metabolism of Amyloid Precursor Protein

D. Klimis-Zacas, Maria Tsachaki, F. Lamari, 2012, Phytotherapy research : PTR.

BRI2 INTERACTS WITH APP AND REGULATES A β PRODUCTION

J. Ghiso, Maria Tsachaki, A. Rostagno, 2005 .

A novel Polish presenilin‐1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years

J. Buxbaum, J. Wegiel, H. Wiśniewski, 1998, NeuroReport.

The Kunitz Protease Inhibitor Form of the Amyloid Precursor Protein (KPI/APP) Inhibits the Proneuropeptide Processing Enzyme Prohormone Thiol Protease (PTP)

N. Robakis, W. V. Van Nostrand, S. Yasothornsrikul, 1999, The Journal of Biological Chemistry.

Ageing research in Greece

Nektarios Tavernarakis, G. Panayotou, D. Kletsas, 2002, Experimental Gerontology.

Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations

H. Wiśniewski, T. Wisniewski, S. Efthimiopoulos, 1999, Neuroscience Letters.

Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein.

J. Shioi, N. Robakis, M. Pangalos, 1996, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

Enrichment of Presenilin 1 Peptides in Neuronal Large Dense‐Core and Somatodendritic Clathrin‐Coated Vesicles

A. Georgakopoulos, J. Shioi, N. Robakis, 1998, Journal of neurochemistry.

Chondroitin sulfate proteoglycan form of cellular and cell-surface Alzheimer amyloid precursor

J. Shioi, N. Robakis, L. Refolo, 1993, Neuroscience Letters.

Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production

Georgia Rapti, L. Parisiadou, S. Efthimiopoulos, 2008, Neurobiology of Disease.

Cellular Processing and Proteoglycan Nature of Amyloid Precursor Proteins a

J. Shioi, N. Robakis, L. Refolo, 1993, Annals of the New York Academy of Sciences.

Structural and regulatory elements of the interaction between amyloid-β protein precursor and Homer3.

S. Efthimiopoulos, Elli Kyratzi, Anastasios Liakos, 2015, Journal of Alzheimer's disease : JAD.

Downregulation of AβPP enhances both calcium content of endoplasmic reticulum and acidic stores and the dynamics of store operated calcium channel activity.

P. Papazafiri, S. Efthimiopoulos, A. Fotinopoulou, 2013, Journal of Alzheimer's disease : JAD.

Oxygen and Glucose Deprivation Alter Synaptic Distribution of Tau Protein: The Role of Phosphorylation.

P. Papazafiri, S. Haralambous, S. Efthimiopoulos, 2017, Journal of Alzheimer's disease : JAD.

Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells.

N. Robakis, S. Efthimiopoulos, N. Tezapsidis, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection

Maria Tsachaki, P. Cordopatis, F. Lamari, 2011, Behavioural Brain Research.

BRI2 homodimerizes with the involvement of intermolecular disulfide bonds

J. Ghiso, Maria Tsachaki, A. Rostagno, 2010, Neurobiology of Aging.

BRI2 Interacts with Amyloid Precursor Protein (APP) and Regulates Amyloid β (Aβ) Production*

J. Ghiso, Maria Tsachaki, A. Rostagno, 2005, Journal of Biological Chemistry.

BRI2 as a central protein involved in neurodegeneration

J. Ghiso, Maria Tsachaki, S. Efthimiopoulos, 2008, Biotechnology journal.

Knockdown of Amyloid Precursor Protein Increases Ion Channel Expression and Alters Ca2+ Signaling Pathways

P. Papazafiri, S. Efthimiopoulos, Danai Liaropoulou, 2023, International journal of molecular sciences.

Amyloid-β Protein Precursor Regulates Depolarization-Induced Calcium-Mediated Synaptic Signaling in Brain Slices.

P. Papazafiri, S. Efthimiopoulos, Maria Chatzistavraki, 2020, Journal of Alzheimer's disease : JAD.

Kinetics of dopamine and noradrenaline transport in synaptosomes from cerebellum, striatum and frontal cortex of normal and reeler mice

T. Valcana, S. Efthimiopoulos, P. Giompres, 1991, Journal of neuroscience research.

Presenilin‐1: A Component of Synaptic and Endothelial Adherens Junctions

A. Georgakopoulos, J. Shioi, N. Robakis, 2000, Annals of the New York Academy of Sciences.

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts.

A. Georgakopoulos, J. Shioi, N. Robakis, 1999, Molecular cell.

Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.

J. Ghiso, Maria Tsachaki, S. Efthimiopoulos, 2011, Glycobiology.

Glycosylation of BRI 2 on asparagine 170 is involved in its traf fi cking to the cell surface but not in its processing by furin or ADAM 10

J. Ghiso, Maria Tsachaki, S. Efthimiopoulos, 2011 .

A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions

G. Serban, L. Baki, A. Georgakopoulos, 2002, The EMBO journal.

The Chondroitin Sulfate Attachment Site of Appican Is Formed by Splicing Out Exon 15 of the Amyloid Precursor Gene (*)

J. Shioi, N. Robakis, M. Pangalos, 1995, The Journal of Biological Chemistry.

Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide

R. Reiter, R. Bick, M. Pappolla, 1997, The Journal of Neuroscience.

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains.

J. Shioi, N. Robakis, C. Bouras, 1996, Journal of neuroscience research.

Notch 1 interacts with the amyloid precursor protein in a Numb‐independent manner

P. Mehta, S. Efthimiopoulos, Angeliki Fassa, 2005, Journal of neuroscience research.

Investigation of genetic base in the treatment of age-related macular degeneration

K. Lamnissou, S. Efthimiopoulos, G. Tsaousis, 2020, International ophtalmology.

An integrated bacterial system for the discovery of chemical rescuers of disease-associated protein misfolding

F. Kolisis, N. Chondrogianni, E. Gonos, 2017, Nature Biomedical Engineering.

Calcium regulates the interaction of amyloid precursor protein with Homer3 protein

S. Efthimiopoulos, Elli Kyratzi, 2014, Neurobiology of Aging.

Atypical Presentations of Alzheimer’s Disease: Beyond Amnestic Dementia

G. Tsivgoulis, G. Paraskevas, Ioanna Tsantzali, 2020 .

BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.

J. Ghiso, Maria Tsachaki, A. Rostagno, 2005, The Journal of biological chemistry.

Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11α

L. Parisiadou, S. Efthimiopoulos, 2007, Neurobiology of Aging.

BRI2 interacts with BACE1 and regulates its cellular levels by promoting its degradation and reducing its mRNA levels.

J. Ghiso, Maria Tsachaki, S. Efthimiopoulos, 2013, Current Alzheimer research.

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

L. Baki, A. Georgakopoulos, J. Shioi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

An integrated bacterial system for the discovery of chemical rescuers of disease-associated protein misfolding

F. Kolisis, N. Chondrogianni, E. Gonos, 2017, Nature Biomedical Engineering.

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

J. Shioi, N. Robakis, C. Bouras, 1996 .

Appican Expression Induces Morphological Changes in C6 Glioma Cells and Promotes Adhesion of Neural Cells to the Extracellular Matrix

J. Shioi, N. Robakis, M. Pangalos, 1997, The Journal of Neuroscience.

Mechanism of amyloid beta-peptide (1-42) toxicity in PC12 cells.

S. Efthimiopoulos, M. Fągąrąsan, 1996, Molecular psychiatry.

421 The mechanism of amyloid β-Peptide (1–42) toxicity in PC12 cells

S. Efthimiopoulos, M. Fągąrąsan, 1996, Neurobiology of Aging.

Calcium regulates the interaction of amyloid precursor protein with Homer3 protein

S. Efthimiopoulos, Elli Kyratzi, 2014, Neurobiology of Aging.

Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies.

V. Sarli, S. Thysiadis, S. Katsamakas, 2016, European journal of medicinal chemistry.

Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes.

N. Robakis, S. Yasothornsrikul, K. Sambamurti, 1998, Biochemistry.