Sanjiv J. Shah

发表

PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1*

Hong Wang, Hongqiao Li, Huaxi Xu, 2003, The Journal of Biological Chemistry.

Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys.

C. Kenific, C. Moxham, B. Pan, 2015, Bioorganic & medicinal chemistry letters.

Development of Anti-CD74 Antibody-Drug Conjugates to Target Glucocorticoids to Immune Cells.

D. Zaller, S. Antonenko, A. Palmieri, 2018, Bioconjugate chemistry.

Cystic fibrosis transmembrane conductance regulator in human and mouse red blood cell membranes and its interaction with ecto‐apyrase

E. Abraham, A. Salikhova, Sanjiv J. Shah, 2004, Journal of cellular biochemistry.

Characterizing Pharmacokinetic–Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation

H. Houshyar, Hongshi Yu, S. Alves, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch*

Hongqiao Li, Sheu-Fen Lee, Gang Yu, 2002, The Journal of Biological Chemistry.

Glu-333 of Nicastrin Directly Participates in γ-Secretase Activity*

Daniel R. Dries, M. Shearman, Yuhong Han, 2009, The Journal of Biological Chemistry.

Nicastrin functions as a gamma-secretase-substrate receptor.

T. Südhof, K. Tabuchi, C. Dann, 2005, Cell.

Potent benzoazepinone γ-secretase modulators with improved bioavailability.

C. Kenific, A. Szewczak, C. Moxham, 2015, Bioorganic & medicinal chemistry letters.

Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators.

M. Altman, X. Fradera, Hongshi Yu, 2021, Journal of medicinal chemistry.

Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors.

M. Augustin, X. Fradera, Karin M. Otte, 2020, ACS medicinal chemistry letters.

Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.

T. Fischmann, M. Altman, X. Fradera, 2019, Journal of medicinal chemistry.

Triazoloamides as potent γ-secretase modulators with reduced hERG liability.

A. Szewczak, C. Moxham, Hua Zhou, 2012, Bioorganic & medicinal chemistry letters.

Supplemental Data Nicastrin Functions as a γ-Secretase-Substrate Receptor

T. Südhof, K. Tabuchi, C. Dann, 2005 .

Triazoles as γ-secretase modulators.

C. Kenific, A. Szewczak, Hua Zhou, 2011, Bioorganic & medicinal chemistry letters.

Quinazolinones as γ-secretase modulators.

A. Szewczak, J. Crispino, B. Muñoz, 2011, Bioorganic & medicinal chemistry letters.

Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.

I. Kariv, C. Moxham, Thomas A. Miller, 2012, Bioorganic & medicinal chemistry letters.

Purine derivatives as potent gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors.

M. Augustin, X. Fradera, A. Bass, 2019, Bioorganic & medicinal chemistry letters.

γ-Secretase-regulated Proteolysis of the Notch Receptor by Mitochondrial Intermediate Peptidase*

Daniel R. Dries, Yun Wang, Bing Wang, 2011, The Journal of Biological Chemistry.

Nicastrin Functions as a γ-Secretase-Substrate Receptor

T. Südhof, K. Tabuchi, C. Dann, 2005, Cell.

γ‐Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease

B. Muñoz, Richard W. Heidebrecht, Christopher L. Hamblett, 2011 .

Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow.

M. Augustin, M. Altman, X. Fradera, 2019, Bioorganic & medicinal chemistry letters.

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates.

Ying Sun, P. Schultz, A. Palmieri, 2016, Journal of the American Chemical Society.

A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex*

P. Thomas, Sheu-Fen Lee, J. Lundkvist, 2004, Journal of Biological Chemistry.

1H, 13C and 15N NMR assignments and solution secondary structure of rat Apo-S100β

David J Weber, D. Hilt, F. Abildgaard, 1995 .

A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system

D. Zaller, M. Crackower, H. Houshyar, 2017, PloS one.

Discovery of a new series of PI3K-δ inhibitors from Virtual Screening.

M. Augustin, M. Altman, X. Fradera, 2021, Bioorganic & medicinal chemistry letters.

Fluorinated piperidine acetic acids as gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.

Alexey Rivkin, Chaomin Li, A. Szewczak, 2010, Bioorganic & Medicinal Chemistry Letters.

Identification of lysyl oxidase and other platelet-derived growth factor-inducible genes in vascular smooth muscle cells by differential screening.

R. Green, A. Weintraub, H. Kagan, 1995, Laboratory investigation; a journal of technical methods and pathology.