R. Sharples

发表

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

C. Masters, G. Evin, D. Hoke, 2005, Biochemistry.

Defining the purity of exosomes required for diagnostic profiling of small RNA suitable for biomarker discovery

Lesley Cheng, A. Hill, S. Bellingham, 2016, RNA biology.

Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.

C. Masters, K. Beyreuther, G. Evin, 2000, Experimental cell research.

Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide*

C. Masters, A. Hill, R. Cherny, 2008, Journal of Biological Chemistry.

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide.

C. Masters, A. Hill, P. Crouch, 2008, The international journal of biochemistry & cell biology.

Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture.

C. Masters, A. Hill, R. Cappai, 2008, The international journal of biochemistry & cell biology.

Alternative transcripts of presenilin‐1 associated with frontotemporal dementia

C. Masters, K. Beyreuther, R. Cappai, 2002, Neuroreport.

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

C. Masters, K. Beyreuther, G. Evin, 2001, Biochemistry.

Melittin peptides exhibit different activity on different cells and model membranes

J. Wade, Steven Batinovic, F. Separovic, 2014, Amino Acids.

Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

C. Rowe, R. Martins, C. Masters, 2014, Molecular Psychiatry.

Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells – Evidence of unique microRNA cargos

Marcela Dávila López, J. Lötvall, Lesley Cheng, 2015, RNA biology.

The role of exosomes in the processing of proteins associated with neurodegenerative diseases

A. Hill, R. Cappai, R. Nisbet, 2008, European Biophysics Journal.

Inhibition of γ‐secretase causes increased secretion of amyloid precursor protein C‐terminal fragments in association with exosomes

C. Masters, A. Hill, R. Nisbet, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

Lesley Cheng, A. Hill, A. Bowie, 2017, Nature Communications.

BRAFV600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells

J. Lötvall, Lesley Cheng, A. Hill, 2017, Proceedings of the National Academy of Sciences.

Intracellular Itinerary of Internalised β‐Secretase, BACE1, and Its Potential Impact on β‐Amyloid Peptide Biogenesis

A. Hill, P. Gleeson, Isabelle Gasnereau, 2013, Traffic.

Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity*

C. Masters, A. Hill, A. Bush, 2006, Journal of Biological Chemistry.

Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood

Lesley Cheng, A. Hill, R. Sharples, 2014, Journal of extracellular vesicles.

Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex.

C. Masters, B. Dean, R. Cappai, 2004, Brain research. Molecular brain research.

Site of fluorescent label modifies interaction of melittin with live cells and model membranes.

G. Ciccotosto, J. Wade, F. Separovic, 2015, Biochimica et biophysica acta.

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

C. Masters, A. Hill, R. Cherny, 2007, The Biochemical journal.

Figures and Tables Gene dysregulation is restored in the Parkinson ’ s disease MPTP neurotoxic mice model upon treatment of the therapeutic drug CuII ( atsm )

Lesley Cheng, A. Hill, N. Sherratt, 2016 .