S. Ellis

Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity*

T. Bonnert, D. Beher, M. Shearman, 2005, Journal of Biological Chemistry.

Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes.

I. Churcher, D. Beher, M. Shearman, 2006, The Journal of biological chemistry.

The novel γ secretase inhibitor MRK-560 reduces amyloid plaque deposition without evidence of Notch-related pathology in the Tg 2576 mouse

T. Rosahl, Michael A. Reilly, J. Best, 2006 .

The non‐peptidyl fungal metabolite L‐783,281 activates TRK neurotrophin receptors

J. Bilsland, L. Young, S. Harper, 2001, Journal of neurochemistry.

Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors.

P. Lograsso, S. Pollack, P. Hunt, 2005, Archives of biochemistry and biophysics.

The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor.

J. Bilsland, L. Young, S. Harper, 1999, Molecular pharmacology.

The Novel γ Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse

Timothy Harrison, J. Atack, T. Rosahl, 2007, Journal of Pharmacology and Experimental Therapeutics.

Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-l-alaninamide]

A. Nadin, J. Atack, Michael A. Reilly, 2005, Journal of Pharmacology and Experimental Therapeutics.