K. Horré

发表

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.

S. Hébert, B. de Strooper, W. Annaert, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Impaired adult hippocampal neurogenesis in Alzheimer’s disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement

R. D'Hooge, B. de Strooper, H. Zetterberg, 2020, bioRxiv.

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

R. D'Hooge, S. Stroobants, B. de Strooper, 2013, The Journal of Neuroscience.

PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome

Amaia M. Arranz, B. de Strooper, P. Agostinis, 2018, Proceedings of the National Academy of Sciences.

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

R. D'Hooge, B. de Strooper, R. Vandenberghe, 2022, bioRxiv.

Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions

Nick C Fox, B. Strooper, C. Hopf, 2021, Cell.

Destabilized γ-Secretase-Aβn interactions cause Alzheimer’s disease, implications for drug discovery

Nick C Fox, B. Strooper, C. Hopf, 2017 .

PLD3 gene and processing of APP

Amaia M. Arranz, B. Strooper, T. Saido, 2017, Nature.

Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer’s disease

Amaia M. Arranz, B. Strooper, H. Zetterberg, 2022, bioRxiv.

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore*

B. de Strooper, A. Tolia, I. Bezprozvanny, 2011, The Journal of Biological Chemistry.

Presenilins Mutated at Asp-257 or Asp-385 Restore Pen-2 Expression and Nicastrin Glycosylation but Remain Catalytically Inactive in the Absence of Wild Type Presenilin*

B. de Strooper, C. van Broeckhoven, W. Annaert, 2003, Journal of Biological Chemistry.

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.

R. D'Hooge, B. de Strooper, H. Zetterberg, 2021, Cell stem cell.

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression

A. Delacourte, S. Hébert, K. Horre, 2008, Proceedings of the National Academy of Sciences.

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

A. Delacourte, S. Hébert, K. Horre, 2009, Neurobiology of Disease.

Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms

B. Strooper, J. Wiltfang, A. Tolia, 2006, Journal of neurochemistry.

The dynamic conformational landscape of γ-secretase

K. Horre, B. de Strooper, C. Sachse, 2015, Journal of Cell Science.

γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

R. D'Hooge, B. Hyman, B. de Strooper, 2009, Science.

Nuclear import of the DSCAM‐cytoplasmic domain drives signaling capable of inhibiting synapse formation

D. Schmucker, B. de Strooper, Anne-Sophie de Smet, 2019, The EMBO journal.

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Amaia M. Arranz, B. de Strooper, W. Annaert, 2017, Molecular Neurodegeneration.

Deficiency of Aph1B/C-γ-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

R. D'Hooge, B. Strooper, B. de Strooper, 2008, Proceedings of the National Academy of Sciences.

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models

Sebastian Munck, Dick F. Swaab, Julien Colombelli, 2015, Science Translational Medicine.

Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions

N. Fox, B. Strooper, C. Hopf, 2017, Cell.

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

Sebastian Munck, B. Strooper, S. Munck, 2013, Nature Medicine.

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

B. de Strooper, T. Young-Pearse, R. Vassar, 2020, Molecular Neurodegeneration.

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

B. de Strooper, T. Young-Pearse, R. Vassar, 2020, Molecular Neurodegeneration.

Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase*

B. de Strooper, A. Tolia, K. Horré, 2008, Journal of Biological Chemistry.

Parl Deficiency in Mouse Causes Coenzyme Q Depletion, Complex III Defects, and Leigh-like Syndrome

Amaia M. Arranz, B. de Strooper, P. Agostinis, 2018, bioRxiv.

Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity

S. Hébert, B. Strooper, V. Baert, 2004, Neurobiology of Disease.

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

B. de Strooper, Gerdien E. de Kloe, S. Munck, 2012, Nature Medicine.

Differential contribution of the three Aph1 genes to γ-secretase activity in vivo

S. Hébert, B. Strooper, W. Annaert, 2005 .

The Orphan G Protein–Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

B. De Strooper, A. Delacourte, B. de Strooper, 2009, Science.

The dynamic conformational landscape of γ-secretase

B. de Strooper, C. Sachse, W. Hagen, 2015, Journal of Cell Science.