Jun Wang

发表

Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for γ‐secretase complex formation

A. Goate, Maribel Martínez, E. Walker, 2006, Journal of neurochemistry.

A domain at the C‐terminus of PS1 is required for presenilinase and γ‐secretase activities

A. Goate, J. Wang, Maribel Martínez, 2005 .

Mutations in APP have independent effects on Aβ and CTFγ generation

A. Goate, G. Dolios, Rong Wang, 2004, Neurobiology of Disease.

MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression.

B. Razani, I. Lodhi, Anyuan He, 2020, Cell reports.

Pathogenic cysteine mutations affect progranulin function and production of mature granulins

A. Goate, Jane Y. Wu, C. Cruchaga, 2010, Journal of neurochemistry.

Immune Complex-induced Integrin Activation and L-plastin Phosphorylation Require Protein Kinase A*

E. Brown, Jun Wang, 1999, The Journal of Biological Chemistry.

L-plastin Peptide Activation of αvβ3-mediated Adhesion Requires Integrin Conformational Change and Actin Filament Disassembly*

E. Brown, Jun Wang, Hua Chen, 2001, The Journal of Biological Chemistry.

Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.

J. Morris, A. Goate, K. Mayo, 2011, Archives of neurology.

TMEM 106 B gene polymorphism is associated with age at onset in granulin mutation carriers and plasma granulin protein levels

J. Morris, A. Goate, K. Mayo, 2011 .

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia

J. Morris, A. Goate, N. Cairns, 2008, Human mutation.

Extreme cerebrospinal fluid amyloid β levels identify family with late‐onset Alzheimer's disease presenilin 1 mutation

A. Fagan, J. Morris, D. Holtzman, 2007, Annals of neurology.

Alzheimer’s disease risk variants show association with cerebrospinal fluid amyloid beta

A. Fagan, J. Morris, D. Holtzman, 2009, neurogenetics.

C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

A. Goate, T. Golde, D. Beher, 2006, Journal of neurochemistry.

Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

A. Goate, S. Hecimovic, A. Brunkan, 2004, Neurobiology of Disease.

Novel presenilin 1 variant (P117A) causing Alzheimer's disease in the fourth decade of life

A. Goate, J. Kauwe, S. Chakraverty, 2008, Neuroscience Letters.

Mutations in APP have independent effects on Abeta and CTFgamma generation.

A. Goate, G. Dolios, Rong Wang, 2004, Neurobiology of disease.

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.

A. Goate, S. Hecimovic, A. Brunkan, 2004, Neurobiology of disease.

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and γ‐secretase activity

A. Goate, J. Wang, D. Beher, 2005, Journal of neurochemistry.

Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.

A. Goate, K. Mayo, Carlos Cruchaga, 2011, Archives of neurology.