Xian Zhang

发表

Transcriptional Regulation of PEN-2, a Key Component of the γ-Secretase Complex, by CREB

Huaxi Xu, K. Xia, Zhuohua Zhang, 2006, Molecular and Cellular Biology.

M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation

Yun-wu Zhang, Qilin Ma, Xian Zhang, 2012, Neuroscience Letters.

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.

Jiankun Cui, S. Lipton, Huaxi Xu, 2007, The Journal of biological chemistry.

Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability

Xiuzhen Zhang, Chen-Song Zhang, Xian Zhang, 2022, Molecular Psychiatry.

Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway

Huaxi Xu, Timothy Y. Huang, Yun-wu Zhang, 2019, Front. Aging Neurosci..

Transcriptional regulation of APH‐1A and increased γ‐secretase cleavage of APP and Notch by HIF‐1 and hypoxia

Huaxi Xu, K. Xia, J. Xia, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation

Huaxi Xu, Timothy Y. Huang, Haoyue Sun, 2020, Cell death and differentiation.

SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate

Yun-wu Zhang, Yingjun Zhao, Ke Liu, 2021, National science review.

Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice

Yuan Zhang, Yun-wu Zhang, Xian Zhang, 2022, Neuropsychopharmacology.

Transcriptional Regulation of PEN-2, a Key Component of the (cid:2) -Secretase Complex, by CREB

J. Xia, Yun-wu Zhang, Xue Zhang, 2006 .

RPS23RG1 is Required for Synaptic Integrity and Rescues Alzheimer’s Associated Cognitive Deficits

Yan Liu, Timothy Y. Huang, G. Bu, 2019 .

Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits

Hui Xu, Yun-wu Zhang, Yingjun Zhao, 2022, Molecular therapy. Methods & clinical development.

SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis

Huaxi Xu, Timothy Y. Huang, G. Bu, 2016, The Journal of Neuroscience.

Effect of Sediment Type on Growth and Survival of Juvenile Horseshoe Crabs (Tachypleus tridentatus)

Huaxi Xu, Yun-wu Zhang, Yingjun Zhao, 2009 .

Hypoxia-inducible Factor 1 (HIF-1 )-mediated Hypoxia Increases BACE1 Expression and -Amyloid Generation*

Jiankun Cui, S. Lipton, Huaxi Xu, 2007 .

The γ-secretase complex: from structure to function

Huaxi Xu, Yun-wu Zhang, Xian Zhang, 2014, Front. Cell. Neurosci..

Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders

Yun-wu Zhang, Honghua Zheng, Xian Zhang, 2021, Frontiers in Aging Neuroscience.

Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice

Huaxi Xu, Haoyue Sun, Yun-wu Zhang, 2021, Frontiers in Cell and Developmental Biology.

Pedigree-based study to identify GOLGB1 as a risk gene for bipolar disorder

Yong Wang, Yun-wu Zhang, Xian Zhang, 2022, Translational Psychiatry.

Trafficking regulation of proteins in Alzheimer’s disease

Huaxi Xu, G. Bu, Yun-wu Zhang, 2014, Molecular Neurodegeneration.

USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation

H. Qing, Xiuzhen Zhang, Timothy Y. Huang, 2022, The Journal of clinical investigation.

Loss of RAB39B does not alter MPTP-induced Parkinson’s disease-like phenotypes in mice

Yun-wu Zhang, Xian Zhang, Chong Wang, 2023, Frontiers in Aging Neuroscience.

Role of Rab GTPases in Alzheimer's Disease.

Timothy Y. Huang, Yun-wu Zhang, Xian Zhang, 2018, ACS chemical neuroscience.

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Qiang Xu, Huaxi Xu, Timothy Y. Huang, 2019, PLoS biology.

The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases

Huaxi Xu, Timothy Y. Huang, Hong-Qin Luo, 2018, Front. Aging Neurosci..

Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration

E. Masliah, Bo Xian, John Calvin Reed, 2012, The Journal of Neuroscience.

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

Yun-wu Zhang, Yingjun Zhao, Xian Zhang, 2012, Molecular Neurodegeneration.

CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates β-Cleavage of β-Amyloid Precursor Protein (APP) through Interacting with β-Site APP Cleaving Protein 1 (BACE1)*

Yun-wu Zhang, Yingjun Zhao, Xian Zhang, 2012, The Journal of Biological Chemistry.

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities

Huaxi Xu, Yun-wu Zhang, Honghua Zheng, 2020, Cell Death & Disease.

Overexpression of Human SNX27 Enhances Learning and Memory Through Modulating Synaptic Plasticity in Mice

Huaxi Xu, Haoyue Sun, Yun-wu Zhang, 2020, Frontiers in Cell and Developmental Biology.

RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer’s Disease–Associated Cognitive Deficits

Yan Liu, Huaxi Xu, Timothy Y. Huang, 2019, Biological Psychiatry.

Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice

Yun-wu Zhang, Xian Zhang, Zijie Wang, 2023, Journal of cellular and molecular medicine.

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function

Timothy Y. Huang, Xian Zhang, Yuzhe Zeng, 2023, Cell.

SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse

Huaxi Xu, Timothy Y. Huang, Yun-wu Zhang, 2019, Front. Cell. Neurosci..

TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’s Disease

Haoyue Sun, Yun-wu Zhang, Xian Zhang, 2020, Frontiers in Cell and Developmental Biology.

Novel KCNJ10 Compound Heterozygous Mutations Causing EAST/SeSAME-Like Syndrome Compromise Potassium Channel Function

Haoyue Sun, Xian Zhang, Fengpeng Wang, 2019, Front. Genet..

Bazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer’s Disease

Wencan He, Xian Zhang, Yuanpeng Huang, 2019, Front. Pharmacol..

β_2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice

Timothy Y. Huang, Cong Liu, Yanjiang Wang, 2023, Nature Neuroscience.

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II

Huaxi Xu, G. Bu, Yun-wu Zhang, 2019, Experimental & Molecular Medicine.

Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Haoyue Sun, Yun-wu Zhang, Zhanxiang Wang, 2023, Journal of Neuroinflammation.

Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation*

Jiankun Cui, S. Lipton, Huaxi Xu, 2007, Journal of Biological Chemistry.

Long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer’s disease

L. Zhang, Yun-wu Zhang, Xian Zhang, 2023, Zoological research.

Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice

Yun-wu Zhang, Xian Zhang, Qiuyang Zheng, 2022, Journal of Neuroscience.