I. Kramer

发表

Sclerostin Deficiency Is Linked to Altered Bone Composition

A. Roschger, P. Roschger, E. Paschalis, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Mechanical Load Increases in Bone Formation via a Sclerostin‐Independent Pathway

M. V. D. van der Meulen, N. Kelly, M. McDonald, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Reversing LRP5‐Dependent Osteoporosis and SOST Deficiency–Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity

S. Ettenberg, Feng Cong, C. Halleux, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Does osteocytic SOST suppression mediate PTH bone anabolism?

O. Leupin, M. Kneissel, Hansjoerg Keller, 2010, Trends in Endocrinology & Metabolism.

Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model.

A. Munnich, F. Di Rocco, Davide Komla-Ebri, 2016, The Journal of clinical investigation.

Effects of Long-Term Sclerostin Deficiency on Trabecular Bone Mass and Adaption to Limb Loading Differ in Male and Female Mice

G. Duda, B. Willie, M. Kneissel, 2019, Calcified Tissue International.

Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels

T. Huber, O. Leupin, B. Kinzel, 2014, Proceedings of the National Academy of Sciences.

Mef2c deletion in osteocytes results in increased bone mass

C. Halleux, M. Kneissel, Hansjoerg Keller, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction

C. Hartmann, C. Cromme, T. Pap, 2016, Science Translational Medicine.

Suppression of Sclerostin Alleviates Radiation‐Induced Bone Loss by Protecting Bone‐Forming Cells and Their Progenitors Through Distinct Mechanisms

K. Cengel, X. S. Liu, Yejia Zhang, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Anti‐Sclerostin Antibody Treatment in a Rat Model of Progressive Renal Osteodystrophy

V. Gattone, N. Chen, S. Moe, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Parathyroid Hormone (PTH)–Induced Bone Gain Is Blunted in SOST Overexpressing and Deficient Mice

G. Loots, M. Kneissel, Hansjoerg Keller, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume

Sindhu T Mohanty, M. McDonald, A. Schindeler, 2018, Calcified Tissue International.

Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease.

D. Pahr, H. Malluche, R. Marculescu, 2016, Kidney international.

Control of the SOST Bone Enhancer by PTH Using MEF2 Transcription Factors

F. Natt, G. Loots, O. Leupin, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The skeletal cell‐derived molecule sclerostin drives bone marrow adipogenesis

J. Pettitt, P. Croucher, C. Rosen, 2018, Journal of cellular physiology.

Interleukin‐17A Inhibition Diminishes Inflammation and New Bone Formation in Experimental Spondyloarthritis

I. Blijdorp, F. Kolbinger, D. Baeten, 2019, Arthritis & rheumatology.

Non-Invasive Imaging Demonstrates Clinical Features of Ankylosing Spondylitis in a Rat Adjuvant Model: a Case Study

F. Kolbinger, N. Accart, N. Beckmann, 2016, European journal of histochemistry : EJH.

Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength.

M. McDonald, D. Little, M. Kneissel, 2015, Bone.

Anti-Sclerostin Treatment Prevents Multiple Myeloma Induced Bone Loss and Reduces Tumor Burden

M. Bouxsein, J. Pettitt, P. Croucher, 2015 .

Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice

G. Duda, Haisheng Yang, B. Willie, 2020, Scientific Reports.

Sost deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched in vivo loading experiments in mice

G. Duda, B. Willie, M. Kneissel, 2018, Journal of The Royal Society Interface.

Systemic sclerostin antibody treatment increases osseointegration and biomechanical competence of zoledronic-acid-coated dental implants in a rat osteoporosis model.

S. Ferguson, M. Schnabelrauch, U. Range, 2019, European cells & materials.

Studying gene expression in bone by in situ hybridization.

Rishard Salie, M. Šuša, M. Kneissel, 2012, Methods in molecular biology.

Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone.

Rishard Salie, M. Šuša, Matthias Mueller, 2010, Bone.

Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis

Lynda F. Bonewald, L. Bonewald, Jian Q. Feng, 2010, Molecular and Cellular Biology.

Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function*

Sabine Geisse, Barbara Brannetti, A. Bauer, 2011, The Journal of Biological Chemistry.

Blockage of bone morphogenetic protein signalling counteracts hypertrophy in a human osteoarthritic micro-cartilage model

A. Barbero, I. Martin, S. Chawla, 2020, Journal of Cell Science.

Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis

A. Barbero, I. Martin, T. Ullrich, 2018, Proceedings of the National Academy of Sciences.

Loading‐Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late‐Stage Osteoarthritis

X. S. Liu, Kairui Zhang, Zhaochun Yang, 2018, Arthritis & rheumatology.

Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta.

A. Schindeler, D. Little, M. Kneissel, 2015, Bone.

Sclerostin deficiency modifies the development of CKD-MBD in mice.

J. Floege, N. Marx, R. Kramann, 2018, Bone.

Meckel’s and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible

F. Di Rocco, Davide Komla-Ebri, Y. Heuzé, 2016, Human molecular genetics.

Isolation of mouse osteocytes using cell fractionation for gene expression analysis.

C. Halleux, M. Kneissel, I. Kramer, 2012, Methods in molecular biology.

Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma.

D. Hose, T. Phan, J. Pettitt, 2017, Blood.

Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression

G. Duda, U. Kornak, B. Willie, 2017, Scientific Reports.

BONE OVERGROWTH-ASSOCIATED MUTATIONS IN LRP 4 IMPAIR SCLEROSTIN-FACILITATOR FUNCTION

A. Bauer, M. Schirle, B. Brannetti, 2010 .

Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume

M. McDonald, A. Schindeler, D. Little, 2018, Calcified Tissue International.

Word Count : 4113 Abstract word count : 245 Number of Figures : 7 Number of Supplemental Figures : 2 Number of Supplemental Tables : 1 Number of Supplemental Movies : 0

Hose, Anja, T. Phan, 2017 .

Osseointegration of biochemically modified implants in an osteoporosis rodent model.

S. Ferguson, M. Schnabelrauch, U. Range, 2013, European cells & materials.

Effects of Long-Term Sclerostin Deficiency on Trabecular Bone Mass and Adaption to Limb Loading Differ in Male and Female Mice

G. Duda, B. Willie, M. Kneissel, 2019, Calcified Tissue International.

Sclerostin Antibody Augments the Anabolic Bone Formation Response in a Mouse Model of Mechanical Tibial Loading

M. McDonald, A. Schindeler, D. Little, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial

J. Goldhahn, Yunyu Zhang, S. Brachat, 2022, Nature Medicine.

Discovery of a novel 2-aminopyrazine-3-carboxamide as a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2) for the treatment of fibrodysplasia ossificans progressiva.

N. Stiefl, S. Guth, I. Kramer, 2022, Bioorganic & medicinal chemistry letters.

Homozygous deletion of the Sost gene results in faster union and increased hard callus formation in tibial fractures

M. McDonald, D. Little, M. Kneissel, 2012 .

Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

Cassandra R Diegel, Jun Liu, Jennifer L. Harris, 2023, Bone research.