M. Bretner

发表

Thermodynamic parameters for binding of some halogenated inhibitors of human protein kinase CK2.

P. Maj, J. Poznański, D. Shugar, 2015, Biochemical and biophysical research communications.

Removal of 5'-terminal m7G from eukaryotic mRNAs by potato nucleotide pyrophosphatase and its effect on translation.

W. Filipowicz, A. Shatkin, H. Sierakowska, 1977, Nucleic Acids Research.

Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.

James S. Duncan, D. Litchfield, D. Shugar, 2005, Biochimica et biophysica acta.

High-Yield Regioselective Thiation of Biologically Important Pyrimidinones, Dihydropyrimidinones and Their Ribo, 2′-Deoxyribo and 2′, 3′-Dideoxyribo Nucleosides

D. Shugar, K. Felczak, M. Bretner, 1993 .

CK2-mediated phosphorylation of general repressor Maf1 triggers RNA polymerase III activation

J. Debski, M. Boguta, M. Bretner, 2011 .

Synthesis of 4,5,6,7-Tetrabromo-1H-benzimidazole Derivatives

M. Bretner, E. Łukowska-Chojnacka, 2015 .

New insight into nucleo α-amino acids - Synthesis and SAR studies on cytotoxic activity of β-pyrimidine alanines.

Mariola Koszytkowska-Stawińska, M. Wielechowska, M. Bretner, 2020, Bioorganic chemistry.

Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton

A. Ljubimov, S. Yarmoluk, K. Ahmed, 2011, Molecular and Cellular Biochemistry.

Biological properties and structural study of new aminoalkyl derivatives of benzimidazole and benzotriazole, dual inhibitors of CK2 and PIM1 kinases.

K. Niefind, M. Wielechowska, M. Bretner, 2018, Bioorganic chemistry.

Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity.

M. Koronkiewicz, M. Staniszewska, M. Bretner, 2018, European journal of medicinal chemistry.

Synthesis, in vitro antiproliferative activity and kinase profile of new benzimidazole and benzotriazole derivatives.

M. Wielechowska, M. Bretner, P. Wińska, 2017, Bioorganic chemistry.

P 3 Further modification of inhibitor of CK 2 — 4 , 5 , 6 , 7-tetrabromo-1 H-benzotriazole ( TBBt )

L. Pinna, M. Ruzzene, G. Maira, 2007 .

New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole

M. Bretner, A. Kilanowicz, G. Muszyńska, 2008, Molecular and Cellular Biochemistry.

Purification and Characterization of West Nile Virus Nucleoside Triphosphatase (NTPase)/Helicase: Evidence for Dissociation of the NTPase and Helicase Activities of the Enzyme

H. Schmitz, P. Borowski, K. Felczak, 2001, Journal of Virology.

Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites

A. Ljubimov, L. Pinna, S. Li Calzi, 2008, Molecular and Cellular Biochemistry.

TBBz but not TBBt discriminates between two molecular forms of CK2 in vivo and its implications.

K. Domańska, M. Bretner, P. Zień, 2003, Biochemical and biophysical research communications.

Synthesis of novel polybrominated benzimidazole derivatives-potential CK2 inhibitors with anticancer and proapoptotic activity.

M. Wielechowska, M. Bretner, P. Wińska, 2016, Bioorganic & medicinal chemistry.

Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.

E. Krzywińska, M. Bretner, G. Muszyńska, 2009, Bioorganic & medicinal chemistry.

Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells

M. Koronkiewicz, M. Bretner, P. Wińska, 2018, AntiCancer Research.

Searching for a new anti-HCV therapy: synthesis and properties of tropolone derivatives.

W. Zagórski-Ostoja, M. Bretner, K. Kopanska, 2006, Biochemical and biophysical research communications.

SYNTHESIS AND PROPERTIES OF P1,P2-, P1,P3- AND P1,P4- DINUCLEOSIDE DI-, TRI- AND TETRAPHOSPHATE MRNA 5'-CAP ANALOGUES

R. Rhoads, Z. Wieczorek, E. Darżynkiewicz, 1995 .

Human dihydrofolate reductase is a substrate of protein kinase CK2α.

D. Cysewski, M. Wielechowska, M. Bretner, 2019, Biochemical and biophysical research communications.

Synthesis of novel chiral TBBt derivatives with hydroxyl moiety. Studies on inhibition of human protein kinase CK2α and cytotoxicity properties.

M. Wielechowska, M. Bretner, P. Wińska, 2014, European journal of medicinal chemistry.

Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication.

M. Bretner, Anna Stankiewicz-Drogoń, A. Boguszewska‐Chachulska, 2010, Bioorganic & medicinal chemistry.

Formylation of a metathesis-derived ansa[4]-ferrocene: a simple route to anticancer organometallics.

Mariola Koszytkowska-Stawińska, M. Mrozowicz, M. Bretner, 2020, Dalton transactions.

Studies on the chemoenzymatic synthesis of (R)- and (S)-methyl 3-aryl-3-hydroxypropionates: the influence of toluene-pretreatment of lipase preparations on enantioselective transesterifications

M. Bretner, P. Borowiecki, 2013 .

Theoretical and matrix-isolation experimental studies on 2-thiocytosine and 5-fluoro-2-thiocytosine.

L. Adamowicz, A. Leś, M. J. Nowak, 1993, Biochimica et biophysica acta.

Synthesis of polybrominated benzimidazole and benzotriazole derivatives containing a tetrazole ring and their cytotoxic activity

M. Wielechowska, M. Bretner, P. Wińska, 2016, Monatshefte für Chemie - Chemical Monthly.

Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii.

J. Piekarczyk, M. Bretner, K. Kopanska, 2004, Bioorganic & medicinal chemistry.

Potential bioisosteres of β-uracilalanines derived from 1H-1,2,3-triazole-C-carboxylic acids.

Mariola Koszytkowska-Stawińska, M. Rędowicz, M. Wielechowska, 2019, Bioorganic chemistry.

1H NMR Conformational Study of a Variety of α-Anomers of C5-Substituted 2′-Deoxyuridines: Comparison to Their Antiherpetic β Counterparts

J. Poznański, K. Felczak, M. Bretner, 2001 .

Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogues.

J. Dzik, B. Kierdaszuk, D. Shugar, 1990, Biochemistry.

Synthesis and in vitro antibacterial activity of 5-halogenomethylsulfonyl- benzimidazole and benzotriazole derivatives.

S. Tyski, M. Bretner, Z. Ochal, 2013, Medicinal chemistry.

Design and synthesis of CK2 inhibitors

Małgorzata A. Makowska, M. Bretner, P. Wińska, 2011, Molecular and Cellular Biochemistry.

Synthesis of new optically pure tetrabromobenzotriazole derivatives via lipase-catalyzed transesterification

M. Wielechowska, M. Bretner, Adam M. Wawro, 2013 .

Infrared spectra of 2-thiocytosine and 5-fluoro-2-thiocytosine ; experimental and ab initio studies

L. Adamowicz, A. Leś, M. J. Nowak, 1993 .

Thymidylate synthases from Hymenolepis diminuta and regenerating rat liver: purification, properties, and inhibition by substrate and cofactor analogues.

J. Dzik, M. Kempny, M. Bretner, 1995, Biochimica et biophysica acta.

2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.

J. Dzik, D. Shugar, M. Balińska, 1993, Journal of medicinal chemistry.

Crystal structures of 5-fluoro-dUrd and its 2 and/or 4-thio analogues: models of substituted dUMP pyrimidine ring interacting with thymidylate synthase.

L. Adamowicz, A. Leś, K. Felczak, 1998, Biochimica et biophysica acta.

Thiated pyrimidine deoxynucleoside analogues, potential chemotherapeutic agents, and substrates/inhibitors in various enzyme systems

J. Poznański, J. Dzik, D. Shugar, 1997 .

Synthesis and interactions with thymidylate synthase of 2,4-dithio analogues of dUMP and 5-fluoro-dUMP.

J. Poznański, J. Dzik, D. Shugar, 1996, Biochimica et biophysica acta.

Synthesis of Novel Acyl Derivatives of 3-(4,5,6,7-Tetrabromo-1H-benzimidazol-1-yl)propan-1-ols—Intracellular TBBi-Based CK2 Inhibitors with Proapoptotic Properties

M. Rędowicz, M. Koronkiewicz, M. Wielechowska, 2021, International journal of molecular sciences.

Infrared spectra of 6-azathiouracils: an experimental matrix isolation and theoretical ab initio SCF/6-311G∗∗ study

L. Adamowicz, G. Maes, K. Felczak, 1996 .

Synthesis, Solution Conformation and Anti-HIV Activity of Novel 3-Substituted-2′,3′-Dideoxy-5-Hydroxymethyl-Uridines and Their 4,5-Substituted Analogues

E. De Clercq, J. Poznański, J. Balzarini, 2003, Antiviral chemistry & chemotherapy.

Interaction of 2-thio-5-fluoro-dUMP and 4-thio-5-fluoro-dUMP with mammalian normal and tumour and helminthic thymidylate synthases: influence of C(4)-substituents on specificity for enzyme inactivation.

J. Bertino, J. Dzik, D. Shugar, 1993, Biochemical and biophysical research communications.

Synthesis and Biological Activity of 5-Fluoro-2-thiocytosine Nucleosides

B. Kierdaszuk, D. Shugar, M. Balińska, 1995 .

Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus.

A. Fattom, C. Liao, H. Schmitz, 2003, Journal of medicinal chemistry.

NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.

H. Schmitz, R. Hosmane, P. Borowski, 2002, Acta biochimica Polonica.

Existing and future therapeutic options for hepatitis C virus infection.

M. Bretner, 2005, Acta biochimica Polonica.

Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.

Sarah Schalinski, Krzysztof Ginalski, K. Ginalski, 2003, European journal of biochemistry.

Thiated Analogues of 2′,3′-Dideoxy-3′-fluorothymidine and Their Phosphorylated and Phosphonylated Derivatives: Synthesis, Interaction with HIV Reverse Transcriptase, and In Vitro Anti-HIV Activity

K. Felczak, M. Bretner, T. Kulikowski, 2003, Nucleosides, nucleotides & nucleic acids.

Substrate/inhibition studies of bacteriophage T7 RNA polymerase with the 5'-triphosphate derivative of a ring-expanded ('fat') nucleoside possessing potent antiviral and anticancer activities.

D. Baldisseri, R. Hosmane, M. Bretner, 1999, Bioorganic & medicinal chemistry.

Interaction of the 5'-phosphates of the anti-HIV agents, 3'-azido-3'-deoxythymidine and 3'-azido-2',3'-dideoxyuridine, with thymidylate synthase.

J. Dzik, D. Shugar, W. Rode, 1988, Biochemical and biophysical research communications.

Unbiased Functional Proteomics Strategy for Protein Kinase Inhibitor Validation and Identification of bona fide Protein Kinase Substrates: Application to Identification of EEF1D as a Substrate for CK2

James S. Duncan, D. Litchfield, M. Bretner, 2011, Journal of proteome research.

Casein kinase II-mediated phosphorylation of general repressor Maf1 triggers RNA polymerase III activation

Olivier Lefebvre, Janusz Debski, J. Debski, 2011, Proceedings of the National Academy of Sciences.

NAVIGATING CROSS-KINASE SELECTIVITY SPACE

D. Litchfield, D. Shugar, J. Skierski, 2005 .

Synthesis and Biological Activity of 1H-benzotriazole and 1H-benzimidazole Analogues — Inhibitors of the NTPase/Helicase of HCV and of Some Related Flaviviridae

A. Baier, P. Borowski, M. Bretner, 2005, Antiviral chemistry & chemotherapy.

Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: applications to protein kinase CK2.

D. Litchfield, M. Bretner, Laszlo Gyenis, 2013, Biochimica et biophysica acta.

Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.

B. Kamińska, B. Kaza, A. Ellert-Miklaszewska, 2009, International journal of oncology.

Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α′ Structures

J. Jose, K. Niefind, D. Lindenblatt, 2019, ACS omega.

Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources.

D. Shugar, M. Bretner, P. Zień, 2003, Biochemical and biophysical research communications.

Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2.

D. Litchfield, M. Bretner, A. Kuś, 2013, Journal of proteomics.

Enzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α′

O. Issinger, B. Olsen, K. Niefind, 2011, Molecular and Cellular Biochemistry.

Structure of the human protein kinase CK2 catalytic subunit CK2α' and interaction thermodynamics with the regulatory subunit CK2β.

O. Issinger, B. Olsen, K. Niefind, 2011, Journal of molecular biology.

An Unbiased Evaluation of CK2 Inhibitors by Chemoproteomics

James S. Duncan, David W. Litchfield, T. Haystead, 2008, Molecular & Cellular Proteomics.

A competition between hydrophobic and electrostatic interactions in protein–ligand systems. Binding of heterogeneously halogenated benzotriazoles by the catalytic subunit of human protein kinase CK2

J. Poznański, K. Woźniak, A. Maciejewska, 2020, IUBMB life.

Study of the physicochemical properties of protein kinase CK2 inhibitors -TBBt, TBBi and 2-Me-TBBi

M. Bretner, A. Pobudkowska, E. Łukowska-Chojnacka, 2019, Fluid Phase Equilibria.

Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase.

K. Niefind, D. Lindenblatt, C. Toelzer, 2020, Bioorganic chemistry.

Lipase-Catalyzed Kinetic Resolution of Novel Antifungal N-Substituted Benzimidazole Derivatives.

J. Maurin, M. Staniszewska, M. Bondaryk, 2016, Chirality.

Potent anti-hepatitis B viral activity and inhibition of bacteriophage T7 RNA polymerase by a "fat" nucleoside and its 5'-triphosphate derivative: synthetic, biochemical, and biological studies of 4,8-diamino-6-imino-6H-1-beta-D-ribofuranosyl-imidazo[4,5-E] [1,3]diazepine-5'-triphosphate.

D. Beckett, R. Hosmane, M. Bretner, 1999, Nucleosides & nucleotides.

Nuclear Export of S6K1 II Is Regulated by Protein Kinase CK2 Phosphorylation at Ser-17*

I. Gout, V. Filonenko, D. Litchfield, 2006, Journal of Biological Chemistry.

Simultaneous Inhibition of Protein Kinase CK2 and Dihydrofolate Reductase Results in Synergistic Effect on Acute Lymphoblastic Leukemia Cells

M. Koronkiewicz, M. Bretner, P. Wińska, 2019, AntiCancer Research.

Acyclic analogues of 5-fluoro-dUMP and 5-fluoro-2'-deoxyuridine: synthesis and inhibition of thymidylate synthase and tumour cell growth.

J. Dzik, D. Shugar, K. Felczak, 1998, Acta biochimica Polonica.

Synthesis and Evaluation of ATP-Binding Site Directed Potential Inhibitors of Nucleoside Triphosphatases/ Helicases and Polymerases of Hepatitis C and other Selected Flaviviridae Viruses

S. Behrens, A. Baier, H. Schmitz, 2004, Antiviral chemistry & chemotherapy.

5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.

J. Poznański, J. Dzik, K. Felczak, 2000, Journal of Medicinal Chemistry.

Different properties of four molecular forms of protein kinase CK2 from Saccharomyces cerevisiae.

K. Domańska, K. Kubiński, M. Masłyk, 2005, Acta biochimica Polonica.

Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.

B. Kamińska, B. Kaza, A. Ellert-Miklaszewska, 2009, International journal of oncology.