S. Veenstra

发表

N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists.

P. Acklin, Y. Auberson, M. Schmutz, 1999, Bioorganic & medicinal chemistry letters.

5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists.

P. Acklin, Y. Auberson, M. Biollaz, 1998, Bioorganic & medicinal chemistry letters.

Studies on the active conformation of NK1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs.

C. Betschart, S. Veenstra, K. Hauser, 1997 .

NKP608: a selective NK-1 receptor antagonist with anxiolytic-like effects in the social interaction and social exploration test in rats

S. Ofner, W. Schilling, A. Vassout, 2000, Regulatory Peptides.

Fluorinated Heterocycles: Targets in the Search for Bioactive Compounds and Tools for their Preparation

R. W. Lang, S. Veenstra, P. Martin, 2010 .

5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists.

Y. Auberson, M. Schmutz, S. Bischoff, 1998, Bioorganic & medicinal chemistry letters.

SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist

S. Ofner, A. Vassout, S. Veenstra, 1996 .

Additions and Corrections - Organoboron Compounds in Organic Synthesis. 1. Asymmetric Hydroboration.

J. Petersen, T. Imai, S. Masamune, 1985 .

Intramolecular [2+2] Cycloadditons of Ketenes and Olefins

B. Ernst, S. Veenstra, A. D. Mesmaeker, 1989 .

Stereocontrolled formation of 1,2-dihydroindoles

W. Speckamp, S. Veenstra, R. Vijn, 1987 .

One-pot synthesis of protected homoallyl amines

S. Veenstra, P. Schmid, 1997 .

Studies on the active conformation of the NK1 antagonist CGP 49823. Part 21. Fluoro-olefin analogs of tertiary amide rotamers.

S. Veenstra, K. Hauser, P. Felber, 1997 .

SAR of 2-benzyl-4-aminopiperidines NK1 antagonists. Part 21. synthesis of CGP 49823

S. Ofner, C. Betschart, W. Schilling, 1996 .

CGP 49823, a novel NK1 receptor antagonist: Behavioural effects

S. Ofner, A. Vassout, C. Gentsch, 1994, Neuropeptides.

Diastereoselective, One-Pot Synthesis of ?-Amino Alcohols from Ketimines

S. Veenstra, S. S. Kinderman, 2001 .

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides.

M. Staufenbiel, J. Rondeau, S. Desrayaud, 2013, Bioorganic & medicinal chemistry letters.

Intramolecular [2+2] cycloadditions of vinylketenes to olefins. Part II. The synthesis of a linear annelated triquinane derivative.

B. Ernst, S. Veenstra, A. D. Mesmaeker, 1988 .

Intramolecular [2+2] cycloadditions of ketenes and vinylketenes to olefins - III. The synthesis of angular annulated triquinane derivatives

B. Ernst, S. Veenstra, A. D. Mesmaeker, 1988 .

Cyclooctatetraenetitanium complexes containing two acetylene units

S. Veenstra, H. V. D. Wal, H. Meijer, 1980 .

Stereocontrolled Formation of 1,2-Dihydroindoles.

W. Speckamp, S. Veenstra, R. Vijn, 1987 .

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.

Jean-Michel Rondeau, Marina Tintelnot-Blomley, M. Staufenbiel, 2009, Bioorganic & medicinal chemistry letters.

Anxiolytic effect of NKP608, a NK1-receptor antagonist, in the social investigation test in gerbils

A. Vassout, C. Gentsch, M. Cutler, 2002, Behavioural Brain Research.

A stereoselective synthesis of indole alkaloid intermediates via N-acyliminium cyclizations

W. Speckamp, S. Veenstra, 1981 .

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

M. Staufenbiel, S. Vormfelde, N. Beckmann, 2018, EMBO molecular medicine.

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

M. Staufenbiel, G. Laue, D. Shimshek, 2015, Molecular Neurodegeneration.

Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.

Jean-Michel Rondeau, Marina Tintelnot-Blomley, P. Paganetti, 2009, Bioorganic & medicinal chemistry letters.

5-Aminomethylquinoxaline-2,3-diones. Part 1. A Novel Class of AMPA Receptor Antagonists.

Y. Auberson, M. Schmutz, S. Bischoff, 1998 .

Corrigendum to “Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 1361–1365]

Siem J. Veenstra, Jean-Michel Rondeau, Marina Tintelnot-Blomley, 2009 .

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

M. Staufenbiel, G. Laue, D. Shimshek, 2015, Molecular Neurodegeneration.

Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.

M. Staufenbiel, P. Paganetti, J. Rondeau, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360.

Mathias Frederiksen, Philipp Holzer, M. Staufenbiel, 2021, Journal of medicinal chemistry.

CGP 49823, a novel, non-peptidic NK-1 receptor antagonist: in vitro pharmacology

J. Heid, S. Ofner, L. Criscione, 1994, Neuropeptides.

THE BACE INHIBITOR NB-360 HAS EXCELLENT BRAIN PENETRATION AND EFFICACY ON AMYLOID-B LOAD IN ANIMAL MODELS

M. Staufenbiel, G. Laue, D. Shimshek, 2014, Alzheimer's & Dementia.

Effect of a novel series of macrocyclic hypolipidemic agents on plasma lipid and lipoprotein levels of four non-primate species.

P. Traxler, J. Gibson, S. Veenstra, 1992, Atherosclerosis.

Enantioselective 1,5-electrocyclization. Synthesis of optically active indolines

W. Speckamp, S. Veenstra, 1982 .