B. Ledoussal

发表

Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.

M. Ruff, E. le Rouzic, N. Lévy, 2019, Journal of Medicinal Chemistry.

Unique Biological Properties and Molecular Mechanism of 5,6-Bridged Quinolones

T. Morris, P. Renick, D. Ellis, 2003, Antimicrobial Agents and Chemotherapy.

The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

B. Berkhout, Felipe García, J. Gatell, 2017, Retrovirology.

Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration

A. Saïb, R. Benarous, B. Klaholz, 2018, The Journal of Biological Chemistry.

Fluoronaphthyridines as antibacterial agents. 4. Synthesis and structure-activity relationships of 5-substituted-6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8- naphthyridine-3-carboxylic acids.

P. D. Di Cesare, R. Kessler, B. Ledoussal, 1992, Journal of medicinal chemistry.

Activity of non-fluorinated quinolones (NFQs) against quinolone-resistant Escherichia coli and Streptococcus pneumoniae.

S. Roychoudhury, C. Catrenich, B. Ledoussal, 2001, The Journal of antimicrobial chemotherapy.

Quinolone Resistance in Staphylococci: Activities of New Nonfluorinated Quinolones against Molecular Targets in Whole Cells and Clinical Isolates

S. Roychoudhury, C. Catrenich, Helana D. McKeever, 2001, Antimicrobial Agents and Chemotherapy.

Vectorization efforts to increase Gram-negative intracellular drug concentration: a case study on HldE-K inhibitors.

B. Ledoussal, F. Moreau, D. Atamanyuk, 2013, Journal of medicinal chemistry.

The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

B. Berkhout, Felipe García, M. Plana, 2017, Retrovirology.

An investigation into the total synthesis of clerocidin: stereoselective synthesis of a clerodane intermediate

B. Ledoussal, T. Demuth, J. K. Almstead, 1998 .

Synthesis and biological testing of non-fluorinated analogues of levofloxacin.

J. Gray, B. Ledoussal, Cynthia D. Wallace, 2003, Bioorganic & Medicinal Chemistry Letters.

Fluoronaphthyridines and -quinolones as antibacterial agents. 5. Synthesis and antimicrobial activity of chiral 1-tert-butyl-6-fluoro-7-substituted-naphthyridones.

P. D. Di Cesare, R. Kessler, B. Ledoussal, 1992, Journal of medicinal chemistry.

Regio- and stereo-controlled copper organometallic addition to a piperidinyl aziridine: synthesis of trans 3-amino-4-alkyl-piperidines

A. Colson, B. Ledoussal, X. Hu, 2002 .

Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens.

W. Seibel, J. Gray, B. Ledoussal, 2003, Journal of medicinal chemistry.

Synthesis and Biological Testing of Non‐Fluorinated Analogues of Levofloxacin.

J. Gray, B. Ledoussal, Cynthia D. Wallace, 2003 .

Potent non-6-fluoro-substituted quinolone antibacterials: synthesis and biological activity.

B. Ledoussal, E. Coroneos, D. Bouzard, 1992, Journal of medicinal chemistry.

Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted derivatives.

R. Kessler, B. Ledoussal, J. Fung-Tomc, 1991, Journal of medicinal chemistry.

Non-fluorinated quinolones (NFQs): new antibacterials with unique properties against quinolone-resistant gram-positive pathogens.

S. Roychoudhury, B. Ledoussal, 2002, Current drug targets. Infectious disorders.

Discovery, Structure-Activity Relationships and Unique Properties of Non- Fluorinated Quinolones (NFQs)

S. Roychoudhury, J. Gray, B. Ledoussal, 2003 .

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

A. Saïb, R. Benarous, O. Delelis, 2013, Retrovirology.

Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors

R. Benarous, S. Emiliani, M. Ruff, 2023, bioRxiv.

Synthesis of trans-(3S)-amino-(4R)-alkyl- and -(4S)-aryl-piperidines via ring-closing metathesis reaction.

B. Ledoussal, X. Hu, Nick K. Kim, 2002, Organic Letters.

Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase

R. Benarous, V. E. Pye, P. Cherepanov, 2023, Antimicrobial agents and chemotherapy.

Staphylococcus aureus Mutants Isolated via Exposure to Nonfluorinated Quinolones: Detection of Known and Unique Mutations

T. Morris, S. Roychoudhury, C. Catrenich, 2001, Antimicrobial Agents and Chemotherapy.

Fluoronaphthyridines and -quinolones as Antibacterial Agents. Part 5. Synthesis and Antimicrobial Activity of Chiral 1-tert-Butyl-6-fluoro-7- Substituted Naphthyridones.

R. Kessler, B. Ledoussal, J. Fung-Tomc, 1993 .

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

A. Saïb, R. Benarous, O. Delelis, 2013, Retrovirology.