Sammy Metobo

发表

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & Medicinal Chemistry.

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & medicinal chemistry.

Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

C. Kim, Sammy Metobo, A. Cho, 2012 .

Synthetic studies on ecteinascidin-743: constructing a versatile pentacyclic intermediate for the synthesis of ecteinascidins and saframycins.

Robert M. Williams, Sammy Metobo, W. Jin, 2003, Organic Letters.

Discovery of GS-9688 (Selgantolimod), as a Potent and Selective Oral Toll-like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.

Helen Yu, R. Mackman, T. Appleby, 2020, Journal of medicinal chemistry.

Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors

A. Ray, T. Kirschberg, C. Kim, 2015, Nucleosides, nucleotides & nucleic acids.

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

W. Zhong, M. Fenaux, H. Ye, 2014, Journal of medicinal chemistry.

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.

Huiling Yang, T. Appleby, M. Fenaux, 2017, Bioorganic & medicinal chemistry letters.

Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.

Xiaowu Chen, M. Tsiang, Rachael Lansdown, 2009, Bioorganic & medicinal chemistry letters.

Tricyclic HIV integrase inhibitors: VI. SAR studies of 'benzyl flipped' C3-substituted pyrroloquinolines.

Xiaowu Chen, M. Tsiang, Rachael Lansdown, 2009, Bioorganic & medicinal chemistry letters.

Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs.

Ruby Z Cai, Xiaowu Chen, M. Tsiang, 2008, Bioorganic & medicinal chemistry letters.

Composes inhibant l'integrase

Rachael Lansdown, C. Kim, M. Mish, 2006 .

Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring.

M. Tsiang, C. Kim, Sammy Metobo, 2006, Bioorganic & medicinal chemistry letters.

Annulation Reactions of Chiral Vinylsulfonium Salts with 2-Indolecarboxaldehyde

Sammy Metobo, Kyung-hee Kim, L. Jimenez, 2001 .

Design, Synthesis and Biological Evaluation of Novel Tricyclic HIV-1 Integrase Inhibitors by Modification of Its Pyridine Ring.

M. Tsiang, C. Kim, Sammy Metobo, 2006 .

N-terminal bromodomain of human BRD2 with N-((4-(3-(N-cyclopentylsulfamoyl)-4-methylphenyl)-3-methylisoxazol-5-yl)methyl)acetamide inhibitor

R. Neve, R. Mackman, K. Babaoglu, 2019 .

Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873.

Jennifer R. Zhang, S. Schroeder, J. Link, 2024, ACS medicinal chemistry letters.