Wanchi Fung

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & Medicinal Chemistry.

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & medicinal chemistry.

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.

Xiaohong Liu, G. Opdenakker, R. Geleziunas, 2013, Anticancer research.

The HCV Non-Nucleoside Inhibitor Tegobuvir Utilizes a Novel Mechanism of Action to Inhibit NS5B Polymerase Function

Xiaohong Liu, W. Zhong, J. Neyts, 2012, PloS one.

Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism

Alana G. Lerner, M. Welch, M. Kovalenko, 2020, mAbs.

Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.

J. Chandrasekhar, Helen Yu, S. Wise, 2020, ACS medicinal chemistry letters.

Lipid-Sensing High-Throughput ApoA-I Assays

Xiaohong Liu, J. W. Chisholm, N. Pagratis, 2012, Journal of biomolecular screening.

N-terminal bromodomain of human BRD2 with N-((4-(3-(N-cyclopentylsulfamoyl)-4-methylphenyl)-3-methylisoxazol-5-yl)methyl)acetamide inhibitor

R. Neve, R. Mackman, K. Babaoglu, 2019 .